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Dry Powder Inhalers

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Particulate Products

Part of the book series: Particle Technology Series ((POTS,volume 19))

Abstract

Successful drug delivery using dry powder inhaler (DPI) technology is based on knowledge of pulmonary deposition, targeting and its relationship to aerodynamic particle size distribution. DPI technologies consist of three notable elements, the formulation, the metering system and the mechanism of dispersion as an aerosol. Each of these is discussed below but emphasis is placed on powder formulation, the forces of interaction between particles that must be overcome to disperse them and the means whereby energy is imparted to achieve this objective. Efficient and reproducible drug delivery with respect to aerosol properties and dose are the objectives of product development and a requirement for regulatory approval for satisfactory disease therapy.

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Authors and Affiliations

  1. RTI International, 3040 Cornwallis Rd, Research Triangle Park, Durham, NC, 27709, USA

    Anthony J. Hickey

  2. School of Pharmacy, University of Maryland, 20 N Pine St, Baltimore, MD, 21201, USA

    Zhen Xu

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  1. Anthony J. Hickey
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  2. Zhen Xu
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Correspondence to Anthony J. Hickey .

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  1. Delft University of Technology, Pijnacker, Zuid-Holland, The Netherlands

    Henk G. Merkus

  2. DSM Food Specialities, Delft University of Technology, Delft, Zuid-Holland, The Netherlands

    Gabriel M.H. Meesters

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Hickey, A.J., Xu, Z. (2014). Dry Powder Inhalers. In: Merkus, H., Meesters, G. (eds) Particulate Products. Particle Technology Series, vol 19. Springer, Cham. https://doi.org/10.1007/978-3-319-00714-4_10

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