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Adjuvants and Delivery Methods: Current and Novel

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Fish Vaccines

Part of the book series: Birkhäuser Advances in Infectious Diseases ((BAID))

Abstract

Vaccination is the most appropriate method to control infectious diseases that threaten the aquaculture industry worldwide. Unfortunately, vaccines are usually not able to confer protection on their own, especially those vaccines based on recombinant antigens or inactivated pathogens. Therefore, the use of adjuvants or immunostimulants is often necessary to increase vaccine efficacy. Furthermore, an important additional problem that limits the entry of novel fish vaccines to the market is that many of the vaccines experimentally produced only work when injected (either intraperitoneally or intramuscularly). Therefore, the search for alternative methods of mass vaccine delivery (oral or immersion) should also be addressed in parallel. Unfortunately, it is probable that the search for a specific combination of antigen/adjuvant/delivery method has to be experimentally addressed for each pathogen/fish species, and only a few general conclusions can be drawn from each of these studies. In this chapter, we summarise previous studies performed with both traditional and new generation adjuvants as well as those studies that have explored methods for vaccine delivery alternative to injection.

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Acknowledgements

This work was supported by the European Commission under the 7th Framework Programme for Research and Technological Development (FP7) of the European Union (Grant Agreement 311993 TARGETFISH) and by project AGL2011-29676 from the Spanish Ministerio de Economia y Competitividad (Plan Nacional AGL2011-29676). Furthermore, the Research Council of Norway (contract no. 183204/S40) and the Tromsø Research Foundation are acknowledged for their support.

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Authors and Affiliations

  1. Norwegian College of Fishery Science, University of Tromsø, Tromsø, N-9037, Norway

    Roy Dalmo & Jarl Bøgwald

  2. Centro de Investigación en Sanidad Animal (CISA-INIA), Carretera de Algete a El Casar km. 8.1, Valdeolmos, Madrid, 28130, Spain

    Carolina Tafalla

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  1. Roy Dalmo
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  2. Jarl Bøgwald
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  3. Carolina Tafalla
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Correspondence to Carolina Tafalla .

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Editors and Affiliations

  1. University of Stirling, Institute of Aquaculture, Faculty of Natural Sciences, Stirling, United Kingdom

    Alexandra Adams

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Dalmo, R., Bøgwald, J., Tafalla, C. (2016). Adjuvants and Delivery Methods: Current and Novel. In: Adams, A. (eds) Fish Vaccines. Birkhäuser Advances in Infectious Diseases. Springer, Basel. https://doi.org/10.1007/978-3-0348-0980-1_4

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