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The Role of Inflammatory Cells in Angiogenesis in Multiple Myeloma

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Inflammation and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 816))

Abstract

Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, via production and release of a large spectrum of pro-angiogenic mediators, thus creating the specific microenvironment that favors increased rate of tissue vascularization. In this article, we focus on the immune cell component of the angiogenic process occurring during multiple myeloma progression. We also provide information on some anti-angiogenic properties of immune cells that may be applied for a potential pharmacological use as anti-angiogenic agents in the disease treatment.

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Acknowledgments

The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007–2013) under Grant agreement n°278570 to DR and 278706 to AV.

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Authors and Affiliations

  1. Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124, Bari, Italy

    Domenico Ribatti

  2. Department of Biomedical Sciences and Human Oncology (DIMO), Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124, Bari, Italy

    Angelo Vacca

  3. National Cancer Institute, Giovanni Paolo II, 70124, Bari, Italy

    Domenico Ribatti

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  1. Domenico Ribatti
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  2. Angelo Vacca
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Correspondence to Domenico Ribatti .

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Editors and Affiliations

  1. Dept of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Bharat B. Aggarwal

  2. Dept of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Bokyung Sung

  3. Dep Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Subash Chandra Gupta

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Ribatti, D., Vacca, A. (2014). The Role of Inflammatory Cells in Angiogenesis in Multiple Myeloma. In: Aggarwal, B., Sung, B., Gupta, S. (eds) Inflammation and Cancer. Advances in Experimental Medicine and Biology, vol 816. Springer, Basel. https://doi.org/10.1007/978-3-0348-0837-8_14

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