Abstract
Interleukin-17 (IL-17) plays a major role in various models of immune-mediated tissue injury, including organ-specific autoimmunity, allergic disorders, and microbial infections. Th17 cells are currently the most thoroughly characterized source of IL-17 credited for causing and sustaining the tissue damage mediated by this cytokine. Similar to their Th1 and Th2 counterpart, Th17 cells depend on specific factors for their differentiation from naïve T cell precursors, before acquiring their typical cytokine profile. However, this is not the case for all IL-17-producing cells, particularly for a subset of iNKT cells, termed iNKT17, which are ready to produce this cytokine immediately upon stimulation, in keeping with their capacity to intervene during early stages of the inflammatory response.
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Abbreviations
- iNKT:
-
Invariant natural killer T
- IL:
-
Interleukin
- Th:
-
T helper
- α-GalCer:
-
α-galactosylceramide
- TCR:
-
T cell receptor
- APCs:
-
Antigen-presenting cells
- LPSs:
-
Lipopolysaccharides
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Acknowledgments
We are grateful to E. Schneider and Adrien Hayday for helpful discussions and critical comments on this chapter.
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Michel, ML., Leite-de-Moraes, M.C. (2013). Other Sources of IL-17: iNKT Cells. In: Quesniaux, V., Ryffel, B., Padova, F. (eds) IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0522-3_7
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DOI: https://doi.org/10.1007/978-3-0348-0522-3_7
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