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Gene’s Association with Coronary Stent Stenosis After Drug Eluting Stent: Review

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International Conference on Advanced Intelligent Systems for Sustainable Development (AI2SD’2023) (AI2SD 2023)

Part of the book series: Lecture Notes in Networks and Systems ((LNNS,volume 905))

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Abstract

Drug-eluting stents are frequently employed in cardiovascular coronary revascularization procedures, primarily because of their capacity to limit intimal hyperplasia. Stent stenosis has the potential to manifest within the artery that has been treated, which can ultimately result in procedural failure. One potential factor that may contribute to this failure is the genetic composition of the patients. The aim of this study is to investigate the correlation between genetic diversity, as reported in existing literature, and the incidence of coronary revascularization subsequent to angioplasty and the use of drug-eluting stents. Consequently, the involvement of various genetic systems, including antioxidant genes, the inflammatory system, the renin angiotensin system, the anticoagulant system, and the homeostasis system, is assessed in the context of stent restenosis. In conclusion, the utilization of genetic diagnosis for the NOS3, AGT, ACE, and CYP2C19 genes holds promise in improving treatment outcomes through the implementation of personalized interventions to tackle coronary stent restenosis.

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Authors and Affiliations

  1. Medical School, Laboratory of Genetics and Molecular Pathology, University Hassan II, Casablanca, Morocco

    Rajaa Elmansouri & Amal Tazzite

  2. Department of Cardiology, University Hospital Center Ibn Rochd, Casablanca, Morocco

    Rachida Habbal

  3. Medical Genetic Laboratory, University Hassan II, Casablanca, Morocco

    Hind Dehbi

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  1. Rajaa Elmansouri
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  2. Amal Tazzite
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  3. Hind Dehbi
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  4. Rachida Habbal
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Correspondence to Rajaa Elmansouri .

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Editors and Affiliations

  1. Computer Sciences Department, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essaâdi University, Tangier, Morocco

    Mostafa Ezziyyani

  2. Systems Research Institute, Polish Academy of Science, Warsaw, Poland

    Janusz Kacprzyk

  3. Department of Automatics and Applied Software at the Faculty of Engineering, University "Aurel Vlaicu" Arad and Romanian Academy of Scientists, Arad, Romania

    Valentina Emilia Balas

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Elmansouri, R., Tazzite, A., Dehbi, H., Habbal, R. (2024). Gene’s Association with Coronary Stent Stenosis After Drug Eluting Stent: Review. In: Ezziyyani, M., Kacprzyk, J., Balas, V.E. (eds) International Conference on Advanced Intelligent Systems for Sustainable Development (AI2SD’2023). AI2SD 2023. Lecture Notes in Networks and Systems, vol 905. Springer, Cham. https://doi.org/10.1007/978-3-031-52385-4_39

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