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Bioactive Glasses for Bone Repair Application: A Review of Osteointegration and Controlled Ion Release Capabilities

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TMS 2024 153rd Annual Meeting & Exhibition Supplemental Proceedings (TMS 2024)

Part of the book series: The Minerals, Metals & Materials Series ((MMMS))

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Abstract

This mini-review provides a comprehensive overview of bioactive glasses and their pivotal role in bone repair applications. Bone regeneration is a complex process that requires innovative solutions, and bioactive glasses have emerged as promising candidates. We delve into the composition and unique properties of bioactive glasses, highlighting their biocompatibility and controlled ion release mechanisms. Through case studies and examples, we explore their diverse applications in bone repair. While bioactive glasses offer numerous advantages, we also discuss their limitations and challenges, including regulatory aspects and long-term stability. Looking ahead, we identify current research trends and future prospects, underscoring the exciting potential of bioactive glasses in shaping the landscape of bone repair and dental therapies.

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References

  1. Navarro M, Michiardi A, Castaño O, Planell JA (2008) Biomaterials in orthopaedics. J R Soc Interface 5(27):1137–1158. https://doi.org/10.1098/rsif.2008.0151

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Skallevold HE, Rokaya D, Khurshid Z, Zafar MS (2019) Bioactive glass applications in dentistry. Int J Mol Sci 20(23):5960. https://doi.org/10.3390/ijms20235960

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Mokobia KE, Ifijen IH, Ikhuoria EU (2023). ZnO-NPs-Coated implants with osteogenic properties for enhanced osseointegration. In TMS 2023 152nd Annual Meeting and Exhibition Supplemental Proceedings. The Minerals, Metals and Materials Series. Springer, Cham. https://doi.org/10.1007/978-3-031-22524-6_27.

  4. Rahaman MN, Day DE, Bal BS, Fu Q, Jung SB, Bonewald LF, Tomsia AP (2011) Bioactive glass in tissue engineering. Acta Biomater 7(6):2355–2373. https://doi.org/10.1016/j.actbio.2011.03.016

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Fernandes HR, Gaddam A, Rebelo A, Brazete D, Stan GE, Ferreira JMF (2018) Bioactive glasses and Glass-Ceramics for healthcare applications in bone regeneration and tissue engineering. Mater (Basel) 11(12):2530. https://doi.org/10.3390/ma11122530

    Article  CAS  Google Scholar 

  6. Krishnan V, Lakshmi T (2013) Bioglass: A novel biocompatible innovation. J Adv Pharm Technol and Res 4(2):78–83

    Article  CAS  Google Scholar 

  7. Kumar A, Murugavel S, Aditya A, Boccaccini AR (2017) Mesoporous 45S5 bioactive glass: Synthesis, in vitro dissolution and biomineralization behaviours. J Mater Chem B Mater Biol Med 5(44):8786–8798

    Article  CAS  PubMed  Google Scholar 

  8. Gao Y, Seles MA, Rajan M (2023) Role of bioglass derivatives in tissue regeneration and repair: A review. Rev Adv Mater Sci 62:20220318. https://doi.org/10.1515/rams-2022-0318

    Article  CAS  Google Scholar 

  9. Al-Harbi N, Mohammed H, Al-Hadeethi Y, Bakry AS, Umar A, Hussein MA, Abbassy MA, Vaidya KG, Berakdar GA, Mkawi EM, Nune M (2021) Silica-Based bioactive glasses and their applications in hard tissue regeneration: a review. Pharm (Basel) 14(2):75. https://doi.org/10.3390/ph14020075

    Article  CAS  Google Scholar 

  10. Lindfors N, Geurts J, Drago L, Arts JJ, Juutilainen V, Hyvönen P et al (2017) Antibacterial bioactive glass, S53P4, for chronic bone infections - a multinational study. Adv Exp Med Biol 971:81–92

    Article  PubMed  Google Scholar 

  11. Jones JR (2015) Review of bioactive glass: From Hench to hybrids. Acta Biomater 23(1):S53–S82

    Article  PubMed  Google Scholar 

  12. El-Fiqi A, Kim JH, Kim HW (2015) Osteoinductive fibrous scaffolds of biopolymer/mesoporous bioactive glass nanocarriers with excellent bioactivity and long-term delivery of osteogenic drug. ACS Appl Mater Interfaces 7(2):1140–1152

    Article  CAS  PubMed  Google Scholar 

  13. Mansur H, Costa HS (2008). Nanostructured poly (vinyl alcohol)/bioactive glass and poly (vinyl alcohol)/chitosan/bioactive glass hybrid scaffolds for biomedical applications. Chem Eng J, 137(1)

    Google Scholar 

  14. Cerruti M (2012) Surface characterization of silicate bioceramics. Phil Trans R Soc A 370:1281–1312

    Article  CAS  PubMed  Google Scholar 

  15. Balasubramanian P, Büttner T, Pacheco VM, Boccaccini AR (2018) Boron-containing bioactive glasses in bone and soft tissue engineering. J Eur Ceram Soc 38(3):855–869

    Article  CAS  Google Scholar 

  16. Baino F, Vitale-Brovarone C (2011) Three-dimensional glass-derived scaffolds for bone tissue engineering: Current trends and forecasts for the future. J Biomed Mater Res, Part A 97(4):514–535

    Article  Google Scholar 

  17. Fu Q, Rahaman MN, Fu H, Liu X (2010). Silicate, borosilicate, and borate bioactive glass scaffolds with controllable degradation rate for bone tissue engineering applications. I. Preparation and in vitro degradation. J Biomed Mater Res. Part A, 95(1), 164–171

    Google Scholar 

  18. Gu Y, Huang W, Rahaman MN, Day DE (2013) Bone regeneration in rat calvarial defects implanted with fibrous scaffolds composed of a mixture of silicate and borate bioactive glasses. Acta Biomater 9(11):9126–9136

    Article  CAS  PubMed  Google Scholar 

  19. Mohammadkhah A, Marquardt LM, Elbert SES, Day DE, Harkins AB (2015) Fabrication and characterization of poly-(ε)-caprolactone and bioactive glass composites for tissue engineering applications. Mater Sci Eng, C Mater Biol Appl 49(1):632–639

    Article  CAS  PubMed  Google Scholar 

  20. Mancuso E, Bretcanu OA, Marshall M, Birch MA, McCaskie AW, Dalgarno KW (2017) Novel bioglasses for bone tissue repair and regeneration: Effect of glass design on sintering ability, ion release, and biocompatibility. Mater Des 129:239–248

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Fernandes JS, Reis RL, Pires RA (2017) Wetspun poly-L-(lactic acid)-borosilicate bioactive glass scaffolds for guided bone regeneration. Mater Sci Eng, C 71:252–259

    Article  CAS  Google Scholar 

  22. Neel EAA, Pickup DM, Valappil SP, Newport RJ, Knowles JC (2009) Bioactive functional materials: A perspective on phosphate-based glasses. J Mater Chem 19(6):690–701

    Article  Google Scholar 

  23. Gao Y, Seles MA, Rajan M (2023) Role of bioglass derivatives in tissue regeneration and repair: A review. Rev Adv Mater Sci 62(1):20220318. https://doi.org/10.1515/rams-2022-0318

    Article  CAS  Google Scholar 

  24. Wu C, Chang J (2012) Mesoporous bioactive glasses: Structure characteristics, drug/growth factor delivery and bone regeneration application. Interface Focus 2(3):292–306

    Article  PubMed  PubMed Central  Google Scholar 

  25. Zhang J, Zhao S, Zhu M, Zhu Y, Zhang Y, Liu Z et al (2014) 3D-printed magnetic Fe3O4/MBG/PCL composite scaffolds with multifunctionality of bone regeneration, local anticancer drug delivery and hyperthermia. J Mater Chem B Mater Biol Med 2(43):7583–7595

    Article  CAS  PubMed  Google Scholar 

  26. Lee S, Nagata F, Kato K, Kasuga T, Nakano T (2021) Development of orthophosphosilicate glass/poly(lactic acid) composite anisotropic scaffolds for simultaneous reconstruction of bone quality and quantity. J Biomed Mater Res, Part A 109(5):788–803

    Article  CAS  Google Scholar 

  27. Kim HW, Lee EJ, Jun IK, Kim HE, Knowles JC (2005). Degradation and drug release of phosphate glass/polycaprolactone biological composites for hard-tissue regeneration. J Biomed Mater Res. Part B, Applied Biomaterials, 75(1), 34–41

    Google Scholar 

  28. Yan L, Li H, Xia W (2020) Bioglass could increase cell membrane fluidity with ion products to develop its bioactivity. Cell Prolif 53(11):e12906. https://doi.org/10.1111/cpr.12906

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Pantulap U, Arango-Ospina M, Boccaccini AR (2021) Bioactive glasses incorporating less-common ions to improve biological and physical properties. J Mater Sci - Mater Med 33(1):3. https://doi.org/10.1007/s10856-021-06626-3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Calahoo C, Wondraczek L (2020) Ionic glasses: Structure, properties and classification. J Non-Cryst Solids: X 8:100054. https://doi.org/10.1016/j.nocx.2020.100054

    Article  CAS  Google Scholar 

  31. Cannio M, Bellucci D, Roether JA, Boccaccini DN, Cannillo V (2021) Bioactive glass applications: a literature review of human clinical trials. Materials 14(18):5440. https://doi.org/10.3390/ma14185440

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Brauer DS (2015) Bioactive glasses—structure and properties. Angew Chem Int Ed Engl 54(14):4160–4181. https://doi.org/10.1002/anie.201405310

    Article  CAS  PubMed  Google Scholar 

  33. Blochberger M, Hupa L, Brauer DS (2015). Influence of zinc and magnesium substitution on ion release from Bioglass 45S5 at physiological and acidic pH. Biomed Glas, 1(1). https://doi.org/10.1515/bglass-2015-0009.

  34. Hoppe A, Güldal NS, Boccaccini AR (2011) A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics. Biomaterials 32(11):2757–2774. https://doi.org/10.1016/j.biomaterials.2011.01.004

    Article  CAS  PubMed  Google Scholar 

  35. Negut I, Ristoscu C (2023) Bioactive Glasses for Soft and Hard Tissue Healing Applications—A Short Review. Appl Sci 13:6151. https://doi.org/10.3390/app13106151

    Article  CAS  Google Scholar 

  36. Vizureanu P, Simona Bălțatu M, Victor Sandu A, Cristian Achitei D, Doru Burduhos Nergis D, and Cristina Perju M (2022). New trends in bioactive glasses for bone tissue: a review. Dentistry. IntechOpen. https://doi.org/10.5772/intechopen.100567.

  37. Jafari N, Habashi MS, Hashemi A et al (2022) Application of bioactive glasses in various dental fields. Biomater Res 26:31. https://doi.org/10.1186/s40824-022-00274-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Lindfors NC, Heikkilä JT, Koski I, Mattila K, Aho AJ (2009) Bioactive glass and autogenous bone as bone graft substitutes in benign bone tumors. J Biomed Mater Res B Appl Biomater 90B(1):131–136. https://doi.org/10.1002/jbm.b.31263

    Article  CAS  Google Scholar 

  39. Steinhausen E, Lefering R, Glombitza M, Brinkmann N, Vogel C, Mester B, Dudda M (2021) Bioactive glass S53P4 vs. autologous bone graft for filling defects in patients with chronic osteomyelitis and infected non-unions—a single center experience. J Bone Jt Infect 6:73–83. https://doi.org/10.5194/jbji-6-73-2021

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Oliver JN, Su Y, Lu X, Kuo PH, Du J, Zhu D (2019) Bioactive glass coatings on metallic implants for biomedical applications. Bioact Mater 4:261–270. https://doi.org/10.1016/j.bioactmat.2019.09.002

    Article  PubMed  PubMed Central  Google Scholar 

  41. Wassif RK, Elkayal M, Shamma RN, Elkheshen SA (2021) Recent advances in the local antibiotics delivery systems for management of osteomyelitis. Drug Delivery 28(1):2392–2414. https://doi.org/10.1080/10717544.2021.1998246

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Danewalia SS, Singh K (2021) Bioactive glasses and Glass-Ceramics for hyperthermia treatment of Cancer: State-of-Art, challenges, and future perspectives. Mater Today Biol 10:100100. https://doi.org/10.1016/j.mtbio.2021.100100

    Article  CAS  Google Scholar 

  43. Borges R, Pelosine AM, de Souza ACS, Machado J Jr, Justo GZ, Gamarra LF, Marchi J (2022) Bioactive glasses as carriers of Cancer-Targeted drugs: challenges and opportunities in bone Cancer treatment. Mater (Basel) 15(24):9082. https://doi.org/10.3390/ma15249082

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, University of Benin, P.M.B. 1154, Benin, Edo, Nigeria

    Casmir O. Okereke

  2. Department of Chemistry, Ambrose Ali University, Ekpoma, Edo, Nigeria

    Joshua Osaretin Onaifo

  3. Department of Research Outreach, Rubber Research Institute of Nigeria, Benin, Edo, Nigeria

    Stanley O. Omorogbe & Angela Ijioma Ogbu

  4. Department of Sociology and Anthropology, Benson Idahosa University, Benin, Edo, Nigeria

    Ikhazuagbe Hilary Ifijen

Authors
  1. Casmir O. Okereke
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  2. Joshua Osaretin Onaifo
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  3. Stanley O. Omorogbe
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  4. Angela Ijioma Ogbu
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  5. Ikhazuagbe Hilary Ifijen
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Correspondence to Ikhazuagbe Hilary Ifijen .

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    Okereke, C.O., Onaifo, J.O., Omorogbe, S.O., Ogbu, A.I., Ifijen, I.H. (2024). Bioactive Glasses for Bone Repair Application: A Review of Osteointegration and Controlled Ion Release Capabilities. In: TMS 2024 153rd Annual Meeting & Exhibition Supplemental Proceedings. TMS 2024. The Minerals, Metals & Materials Series. Springer, Cham. https://doi.org/10.1007/978-3-031-50349-8_28

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