Abstract
Absorbable magnesium (Mg) wires have the potential to replace many permanent medical devices. Permanent devices endure as an unnatural material in the body whereas eventual staples, stents, and sternal wires made from absorbable magnesium can enable complete tissue healing by elimination of most long-term foreign material. Due to magnesium’s relatively rapid degradation rate, thin devices may not provide adequate mechanical support during the entire healing phase without surface modifications or coatings to delay the onset of corrosion. This study aimed to assess the feasibility and effectiveness of absorbable coatings which could be suitable for a range of Mg-based biomedical devices, spanning cardiovascular, orthopedic, and wound closure implants. Mg alloy LZ21 wire was drawn to 0.3 mm and annealed to impart high ductility. A portion of the wire was then anodized in an experimental electrolyte. Anodized wire was then coated with an absorbable polymer jacket of polycaprolactone (PCL). Bare, anodized, and PCL-coated wire were then subjected to both in vitro and in vivo degradation testing to assess coating impact.
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Acknowledgements
U.S. National Institutes of Health, National Heart Blood Lung Institute (Grant 1R15HL167221-01 to RJG) is acknowledged for partially funding this work. The assistance of Dale Herndon, Lane Bailey, Sean Telley, and Harold Perez in wire preparation and testing is gratefully acknowledged.
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Griebel, A.J., David, C.J., Schaffer, J.E., He, W., Guillory, R. (2024). Assessment of Magnesium Wire Coatings for Absorbable Medical Devices. In: Leonard, A., Barela, S., Neelameggham, N.R., Miller, V.M., Tolnai, D. (eds) Magnesium Technology 2024. TMS 2024. The Minerals, Metals & Materials Series. Springer, Cham. https://doi.org/10.1007/978-3-031-50240-8_36
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DOI: https://doi.org/10.1007/978-3-031-50240-8_36
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