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The Significance of Biomaterials in Stem Cell-Based Regenerative Medicine

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Regenerative Medicine and Brain Repair

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL,volume 75))

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Abstract

Introduction: Stem cell-based therapeutic strategies have shown tremendous potential in attenuating tissue damage and facilitating tissue repair and regeneration. The therapeutic benefits of stem cells are largely dependent on the establishment of a supportive microenvironment that optimizes cell survival, differentiation, and functional integration within host tissues. In this chapter, we will provide insight into the pivotal role of biomaterials in augmenting the therapeutic potential of cellular regenerative medicine and offer guidance for future advancements in this field. Methods: This chapter was written with the aid of comprehensive literature reviews found on PubMed and Web of Science Using Materials, Tissue Engineering, and Stem Cells, and websites dedicated to the topic of cell bioengineering. Results: Advances in biomaterials and stem cell research continue to lead to amazing discoveries. Nonetheless, it is clear that this area of research holds great promise, especially in elucidating the ability of biomaterials to enhance stem cell-intrinsic characteristics and modulate their immune microenvironment. Conclusions: Due to remarkable advancements in various disciplines, such as chemistry, materials science, and aerospace engineering, the amalgamation and advancement of biomaterials has gradually permeated the realm of stem cell therapy. These biomaterials offer dynamic and customized platforms to optimize cell-based regenerative strategies.

Meina Liu and Kai Pan are contributed equally to the present work.

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Funding

This study was financially supported by the National Natural Science Foundation of China (U2004126), the Tianjin Natural Science Foundation (22JCZXJC00170, 21JCZDJC00070), the Open funding from Nankai University Eye Institute (NKYKD202203), the Research Project on Skin Injury & Repair (BKJ21J016), and the Tianjin Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-043A).

Disclosure of Interests

All authors declare they have no conflict of interest.

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This article does not contain any studies with animals performed by any of the authors.

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Authors and Affiliations

  1. Puyang People’s Hospital, Puyang, China

    Meina Liu

  2. Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, China

    Meina Liu, Kai Pan & Zhikun Guo

  3. Henan Key Laboratory of Cardiac Remodeling and Transplantation, Zhengzhou Seventh People’s Hospital, Zhengzhou, China

    Meina Liu, Kai Pan & Zhikun Guo

  4. Nankai University School of Medicine, Nankai University, 94 Weijin Road, Tianjin, 300071, China

    Zongjin Li

  5. Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin Central Hospital of Gynecology Obstetrics, Nankai University Affiliated Hospital of Obstetrics and Gynecology, Tianjin, China

    Zongjin Li

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  1. Meina Liu
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  2. Kai Pan
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  3. Zhikun Guo
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  4. Zongjin Li
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Correspondence to Zongjin Li .

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Editors and Affiliations

  1. Department of Anatomy, University of Otago, Dunedin, New Zealand

    Philip V. Peplow

  2. Department of Medicine, University of Nevada Reno, Reno, NV, USA

    Bridget Martinez

  3. Professor Emeritus of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA

    Thomas A. Gennarelli

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Liu, M., Pan, K., Guo, Z., Li, Z. (2024). The Significance of Biomaterials in Stem Cell-Based Regenerative Medicine. In: Peplow, P.V., Martinez, B., Gennarelli, T.A. (eds) Regenerative Medicine and Brain Repair. Stem Cell Biology and Regenerative Medicine, vol 75. Springer, Cham. https://doi.org/10.1007/978-3-031-49744-5_7

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