Abstract
Congestive Heart Failure (CHF) is a significant global health issue and considered the most debilitating form of Heart Failure with the heart unable to efficiently pump enough blood to the body, resulting in a high risk of mortality. Left Ventricular Assist Devices (LVADs) are utilized for providing mechanical circulatory assistance for patients with CHF. LVADs can generate pulsatile or continuous flows. Continuous flow LVADs may induce a more physiological flow pattern with some degree of pulsatility when the device is operated using a physiological type of controller. We present a computational simulator that can be used to compare hemodynamic responses of a simulated patient implanted with a LVAD, operated with or without a physiological controller. The computational simulator described here includes: (i) simulations of the patient’s condition; (ii) mathematical models of the estimators and sensors; and (iii) LVAD physiological control algorithms. The application of the simulator allowed us to investigate the performance of physiological control strategies considering various scenarios for LVAD applications.
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Savarese, G., Becher, P.M., Lund, L.H., Seferovic, P., Rosano, G.M., Coats, A.J.: Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovasc. Res. 118(17), 3272–3287 (2022)
Zipes, D.P., Libby, P., Bonow, R.O., Mann, D.L., Tomaselli, G.F.: Braunwald’s heart disease E-Book: a textbook of cardiovascular medicine. Elsevier Health Sciences (2018)
Mantha, A., Lee, R.O., Wolfson, A.M.: Patient selection for heart transplant: balancing risk. Curr. Opin. Organ Transplant. 27(1), 36–44 (2022)
Yuzefpolskaya, M., Schroeder, S.E., Houston, B.A., Robinson, M.R., Gosev, I., Reyentovich, A., D’Alessandro, D.A.: The society of thoracic surgeons intermacs 2022 annual report: focus on the 2018 heart transplant allocation system. Ann. Thoracic Surg. 115(2), 311–327 (2023)
Stephens, A.F., Gregory, S.D., Burrell, A.J., Marasco, S., Stub, D., Salamonsen, R.F.: Physiological principles of starling-like control of rotary ventricular assist devices. Expert Rev. Med. Dev. 17(11), 1169–1182 (2020)
Stevens, M.C., Stephens, A., AlOmari, A.H.H., Moscato, F.: Physiological control. In: Mechanical Circulatory and Respiratory Support, pp. 627–657. Academic Press (2018)
Pauls, J.P., Stevens, M.C., Bartnikowski, N., Fraser, J.F., Gregory, S.D., Tansley, G.: Evaluation of physiological control systems for rotary left ventricular assist devices: an in-vitro study. Ann. Biomed. Eng. 44, 2377–2387 (2016)
Doshi, D., Burkhoff, D.: Cardiovascular simulation of heart failure pathophysiology and therapeutics. J. Cardiac Fail. 22(4), 303–311 (2016)
Bronicki, R.A., et al.: The cardiovascular system in severe sepsis: insight from a cardiovascular simulator. Pediatr. Crit. Care Med. 23(6), 464–472 (2022)
Guyton, A.C.: Determination of cardiac output by equating venous return curves with cardiac response curves. Physiol. Rev. 35(1), 123–129 (1955)
Guyton, A.C., Pl, C.: Pressure-volume curves of the arterial and venous systems in live dogs. Am. J. Physiol. 184(2), 253–258 (1956)
Owen, B., Bojdo, N., Jivkov, A., Keavney, B., Revell, A.: Structural modelling of the cardiovascular system. Biomech. Model. Mechanobiol. 17(5), 1217–1242 (2018)
Sagawa, K., Lie, R.K., Schaefer, J.: Translation of Otto frank’s paper” Die Grundform des arteriellen Pulses” zeitschrift für biologie 37: 483–526 (1899). J. Mol. Cell. Cardiol. 22(3), 253–254 (1990)
Frank, O.: Grundform des Pulses. Z. Biol. 37, 483–526 (1899)
Stergiopulos, N., Westerhof, B.E., Westerhof, N.: Total arterial inertance as the fourth element of the windkessel model. Am. J. Physiol. Heart Circulat. Physiol. 276(1), H81–H88 (1999)
Burkhoff, D.: Brief history of cardiovascular modeling: insights into pathophysiology and therapeutics. cardiovascular simulation in clinical research and practice (2015)
Torres, D.S., Mazzetto, M., Cestari, I.A.: A novel automated simulator of pediatric systemic circulation: design and applications. Biomed. Signal Process. Control 70, 102926 (2021). https://doi.org/10.1016/j.bspc.2021.102926
Melo, T.R., Neto, J.S.R., Cestari, I.A., Lima, A.M.N.: Feedback controller for restoring the basal hemodynamic condition with a rotary blood pump used as left ventricular assist device. Biomed. Sign. Process. Control 62, 102–136 (2020). https://doi.org/10.1016/j.bspc.2020.102136
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Santos, B.J., Cestari, I.A. (2024). Development of a Computational Simulator of the Physiological Control of Ventricular Assist Devices (VADs). In: Marques, J.L.B., Rodrigues, C.R., Suzuki, D.O.H., Marino Neto, J., García Ojeda, R. (eds) IX Latin American Congress on Biomedical Engineering and XXVIII Brazilian Congress on Biomedical Engineering. CLAIB CBEB 2022 2022. IFMBE Proceedings, vol 98. Springer, Cham. https://doi.org/10.1007/978-3-031-49401-7_47
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DOI: https://doi.org/10.1007/978-3-031-49401-7_47
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