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Modification of Polymeric Scaffolds Made of PEG and Nanohydroxyapatite Embedded with Carbon Dots for Applications in Bone Tissue Regeneration

  • Conference paper
  • First Online:
IX Latin American Congress on Biomedical Engineering and XXVIII Brazilian Congress on Biomedical Engineering (CLAIB 2022, CBEB 2022)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 98))

  • 48 Accesses

Abstract

Composite scaffolds have been used to treat bone defects from severe trauma, pathologies, or congenital malformations. Polymers such as polyethylene glycol (PEG) and ceramics such as nanohydroxyapatite (nHA) have been used for scaffold fabrication due to their mechanical and biological properties, which favor osteoconduction as well as mimic physical and structural characteristics of natural bone. Nanomaterials, such as carbon dots, have been implemented for this application due to their biocompatible nature and ability to improve mechanical properties and enhance biological interactions. Hydroxyapatite nanoparticles embedded with carbon dots (nHA-CD) were obtained by a rapid continuous precipitation method. Carbon dots (CDs) were synthesized by the microwave-assisted method. Characterization performed by UV-Vis spectrophotometry, Scanning electron microscopy (SEM), and Attenuated total reflectance Fourier transform infrared spectroscopy (FTIR-ATR) confirmed the incorporation of CDs in nHA. A scaffold based on PEG and nHA embedded with carbon dots (PEG-nHA-CD) was synthesized using a direct mixing method. The scaffold presented a density of 0,48 g/cm3, similar to that of natural bone, indicating similar physical and structural characteristics. The cytotoxicity of the synthesized samples was evaluated by MTT and Trypan Blue assays. The results showed the potential of the PEG-nHA-CD scaffold fabricated for applications in tissue engineering aimed at future bone tissue applications.

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Acknowledgment

M.M, D.C.R.B, and A.O.M. thank the Colombian School of Engineering Julio Garavito for financial support.

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Authors and Affiliations

  1. Research Incubator Synergia, Colombian School of Engineering Julio Garavito/Universidad del Rosario, Bogota, Colombia

    S. Degiovanni Morales, J. S. Ballestas Pineda, M. A. Molina Daza & P. Mancipe Celis

  2. Clinical Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia

    A. Ondo-Mendez

  3. Gibiome, School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia

    D. C. Rodríguez Burbano

  4. Department of Biomedical Engineering, Colombian School of Engineering Julio Garavito, Bogota, Colombia

    M. Múnera

Authors
  1. S. Degiovanni Morales
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  2. J. S. Ballestas Pineda
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  3. M. A. Molina Daza
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  4. P. Mancipe Celis
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  5. A. Ondo-Mendez
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  6. D. C. Rodríguez Burbano
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  7. M. Múnera
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Corresponding author

Correspondence to D. C. Rodríguez Burbano .

Editor information

Editors and Affiliations

  1. Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering, Federal University of Santa Catarina, Florianópolis, Brazil

    Jefferson Luiz Brum Marques

  2. Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering, Federal University of Santa Catarina, Florianópolis, Brazil

    Cesar Ramos Rodrigues

  3. Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering, Federal University of Santa Catarina, Florianópolis, Brazil

    Daniela Ota Hisayasu Suzuki

  4. Institute of Biomedical Engineering, Federal University of Santa Catarina, Florianópolis, Brazil

    José Marino Neto

  5. Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering, Federal University of Santa Catarina, Florianópolis, Brazil

    Renato García Ojeda

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Morales, S.D. et al. (2024). Modification of Polymeric Scaffolds Made of PEG and Nanohydroxyapatite Embedded with Carbon Dots for Applications in Bone Tissue Regeneration. In: Marques, J.L.B., Rodrigues, C.R., Suzuki, D.O.H., Marino Neto, J., García Ojeda, R. (eds) IX Latin American Congress on Biomedical Engineering and XXVIII Brazilian Congress on Biomedical Engineering. CLAIB CBEB 2022 2022. IFMBE Proceedings, vol 98. Springer, Cham. https://doi.org/10.1007/978-3-031-49401-7_40

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  • DOI: https://doi.org/10.1007/978-3-031-49401-7_40

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-49400-0

  • Online ISBN: 978-3-031-49401-7

  • eBook Packages: EngineeringEngineering (R0)

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