Skip to main content
SpringerLink
Log in

Treatment Planning for Electrochemotherapy of Spinal Metastases

  • Conference paper
  • First Online:
MEDICON’23 and CMBEBIH’23 (MEDICON 2023, CMBEBIH 2023)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 94))

  • 152 Accesses

Abstract

Bone metastases can be effectively treated by electrochemotherapy (ECT). Clinical studies report a reduction in pain, preservation of bone stability, and absence of neurologic symptoms after treatment. The transpedicular approach is a promising approach for the treatment of spinal metastases with ECT. The success and safety of treatment can be improved with computer-assisted treatment planning. Patients’ medical images are used to create an anatomically correct numerical models in which optimal electrode placement and treatment parameters are determined to ensure complete tumor coverage and minimal risk of spinal cord injury. We developed an algorithm to optimize electrode positions and voltages, which significantly reduces the time and expertise required to develop a treatment plan for the transpedicular approach.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 279.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Campanacci, L., Bianchi, G., Cevolani, L., et al.: Operating procedures for electrochemotherapy in bone metastases: results from a multicenter prospective study on 102 patients. Eur. J. Surg. Oncol. 47, 2609–2617 (2021). https://doi.org/10.1016/j.ejso.2021.05.004

    Article  Google Scholar 

  2. Campana, L.G., Edhemovic, I., Soden, D., et al.: Electrochemotherapy–emerging applications technical advances, new indications, combined approaches, and multi-institutional collaboration. Eur. J. Surg. Oncol. 45, 92–102 (2019). https://doi.org/10.1016/j.ejso.2018.11.023

    Article  Google Scholar 

  3. Bianchi, G., Campanacci, L., Ronchetti, M., Donati, D.: Electrochemotherapy in the treatment of bone metastases: a Phase II trial. World J. Surg. 40, 3088–3094 (2016). https://doi.org/10.1007/s00268-016-3627-6

    Article  Google Scholar 

  4. Gasbarrini, A., Campos, W.K., Campanacci, L., Boriani, S.: Electrochemotherapy to metastatic spinal melanoma: a novel treatment of spinal metastasis? Spine 40, E1340-1346 (2015). https://doi.org/10.1097/BRS.0000000000001125

    Article  Google Scholar 

  5. Cornelis, F.H., Ben Ammar, M., Nouri-Neuville, M., et al.: Percutaneous image-guided electrochemotherapy of spine metastases: initial experience. Cardiovasc. Intervent. Radiol. 42, 1806–1809 (2019). https://doi.org/10.1007/s00270-019-02316-4

    Article  Google Scholar 

  6. Fini, M., Salamanna, F., Parrilli, A., et al.: Electrochemotherapy is effective in the treatment of rat bone metastases. Clin. Exp. Metastasis 30, 1033–1045 (2013). https://doi.org/10.1007/s10585-013-9601-x

    Article  Google Scholar 

  7. Tschon, M., Salamanna, F., Ronchetti, M., et al.: Feasibility of electroporation in bone and in the surrounding clinically relevant structures: a preclinical investigation. Technol. Cancer Res. Treat. 15, 737–748 (2016). https://doi.org/10.1177/1533034615604454

    Article  Google Scholar 

  8. Cindrič, H., Kos, B., Tedesco, G., et al.: Electrochemotherapy of spinal metastases using transpedicular approach—a numerical feasibility study. Technol. Cancer Res. Treat. 17, 1533034618770253 (2018). https://doi.org/10.1177/1533034618770253

    Article  Google Scholar 

  9. Corovic, S., Lackovic, I., Sustaric, P., et al.: Modeling of electric field distribution in tissues during electroporation. Biomed. Eng. Online 12, 16 (2013). https://doi.org/10.1186/1475-925X-12-16

    Article  Google Scholar 

  10. Pavšelj, N., Bregar, Z., Cukjati, D., et al.: The course of tissue permeabilization studied on a mathematical model of a subcutaneous tumor in small animals. IEEE Trans. Biomed. Eng. 52, 1373–1381 (2005). https://doi.org/10.1109/TBME.2005.851524

    Article  Google Scholar 

  11. Cindrič, H., Miklavčič, D., Cornelis, F.H., Kos, B.: Optimization of transpedicular electrode insertion for electroporation-based treatments of vertebral tumors. Cancers 14, 5412 (2022). https://doi.org/10.3390/cancers14215412

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia

    Helena Cindrič, Damijan Miklavčič & Bor Kos

Authors
  1. Helena Cindrič
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Damijan Miklavčič
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bor Kos
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Helena Cindrič .

Editor information

Editors and Affiliations

  1. Verlab Research Institute for Biomedical Engineering, Medical Devices, and Artificial Intelligence, Sarajevo, Bosnia and Herzegovina

    Almir Badnjević

  2. Verlab Research Institute for Biomedical Engineering, Medical Devices, and Artificial Intelligence, Sarajevo, Bosnia and Herzegovina

    Lejla Gurbeta Pokvić

Rights and permissions

Reprints and permissions

Copyright information

© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Cindrič, H., Miklavčič, D., Kos, B. (2024). Treatment Planning for Electrochemotherapy of Spinal Metastases. In: Badnjević, A., Gurbeta Pokvić, L. (eds) MEDICON’23 and CMBEBIH’23. MEDICON CMBEBIH 2023 2023. IFMBE Proceedings, vol 94. Springer, Cham. https://doi.org/10.1007/978-3-031-49068-2_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-49068-2_5

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-49067-5

  • Online ISBN: 978-3-031-49068-2

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Search

Navigation