Skip to main content
SpringerLink
Log in

Implantable and Ingestible Biosensors

  • Conference paper
  • First Online:
MEDICON’23 and CMBEBIH’23 (MEDICON 2023, CMBEBIH 2023)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 94))

  • 127 Accesses

Abstract

Implantable and ingestible biosensors are used in medicine and research to monitor patients’ health over extended periods. This review paper focuses on applying these biosensors, their strengths, limitations, stability, and risks. The use of these biosensors has the potential to reduce the costs in the healthcare system and improve the quality of patient treatment. All biosensors mentioned in this review paper allow healthcare workers to monitor patients’ health in real-time and improve their overall quality of life. The ingestible micro bio-electronic device (IMBED) and the My-treatment-medication (MyTMed) have relatively high accuracy and provide information about the gastrointestinal health of the patient. Their high sensitivity is vital for detecting small traces of chemicals in the gastrointestinal tract. Using the ingestible micro-bio-electronic device provides faster detection of gastrointestinal bleeding, especially in gastro intestinal anatomical parts that are hard to reach. My-treatment-medication provides healthcare workers a way to gather information about medication adherence, which was previously based only on the patient's subjective answers. The implantable cardioverter defibrillator and the glucose biosensor prevent heart failure and track the glucose values in the patient's body. Both of them exhibit high accuracy and sensitivity. The irregular heart rate, which can lead to cardiac arrest, can now be monitored and prevented using the implantable cardioverter defibrillator. The glucose biosensor can improve the quality of life of patients who have diabetes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 279.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bhalla, N., Jolly, P., Formisano, N., Estrela, P.: Introduction to biosensors. Essays Biochem. 60(1), 1–8 (2016)

    Article  Google Scholar 

  2. Dharun, V.S., Simon, S.G., Shihab, S & Thahan. S.: Implantable cardioverter defibrillator. Int. J. Appl. Eng. Res. 10(59) (2015)

    Google Scholar 

  3. Ugalmugle, S., Swain, R.: Biosensors market by type. Globalmarketinsight (2019)

    Google Scholar 

  4. Heo, Y.J., Kim, S.H.: Toward long-term implantable glucose biosensors for clinical use. Appl. Sci. 9(10), 2158 (2019)

    Article  Google Scholar 

  5. Chen, C., Zhao, X.L., Li, Z.H., Zhu, Z.G., Qian, S.H., Flewitt, A.J.: Current and emerging technology for continuous glucose monitoring. Sensors 17(1), 182 (2017)

    Article  Google Scholar 

  6. Vaddiraju, S., Tomazos, I., Burgess, D.J., Jain, F.C., Papadimitrakopoulos, F.: Emerging synergy between nanotechnology and implantable biosensors: a review. Biosens. Bioelectron. 25(7), 1553–1565 (2010)

    Article  Google Scholar 

  7. Bhatt, A.S.: Digesting new developments in biosensors. N. Engl. J. Med. 379(7), 686–688 (2018)

    Article  Google Scholar 

  8. Chai, P.R., Rosen, R.K., Boyer, E.W.: Ingestible biosensors for real-time medical adherence monitoring: MyTMed. In: Proceedings of the ... Annual Hawaii International Conference on System Sciences. Annual Hawaii International Conference on System Sciences, pp. 3416–3423 (2016)

    Google Scholar 

  9. Guk, K., et al.: Evolution of wearable devices with real-time disease monitoring for personalized healthcare. Nano Materials (Basel, Switzerland) 9(6), 813 (2019)

    Google Scholar 

  10. Mimee, M., Nadeau, P., Hayward, A., Carim, S., Flanagan, S., Jerger, L., Collins, J., McDonnell, S., Swartwout, R., Citorik, R.J., Bulović, V., Lu, T.K.: An ingestible bacterial-electronic system to monitor gastrointestinal health. Science 360(6391), 915–918 (2018)

    Google Scholar 

  11. Gray, M., et al.: Implantable biosensors and their contribution to the future of precision medicine. The Veterinary J. 239, 21–29 (2018)

    Article  Google Scholar 

  12. DeVries, L.M., Dijk, W.A., Hooijschuur, C.A.M., Leening, M.J.G., Hemel, V.: Utilisation of cardiac pacemakers over a 20-year period: results from a nationwide pace maker registry. Neth Heart J. 25(1), 47–55 (2017)

    Article  Google Scholar 

  13. Masoudi, F.A., Go, A.S., Magid, D.J., Cassidy‐Bushrow, A.E., Gurwitz, J.H., Liu, T.I., Reynolds, K., Smith, D.H., Reifler, L.M., Glenn, K.A., Fiocchi, F., Greenlee, R.T.: Age and sex differences in long‐term outcomes following implantable cardioverter‐defibrillator placement in contemporary clinical practice: findings from the cardiovascular research network. J. Am. Heart Assoc. 4(6), e002005 (2015)

    Google Scholar 

  14. Gastone Ciuti, R., Caliò, D., Camboni, L., Neri, F., Bianchi, A.A.: Frontiers of robotic endoscopic capsules: a review. J. Micro-Bio Robot. 11, 1–18 (2016)

    Article  Google Scholar 

  15. Patel, P.: Gulp! ACS Publications, Electronics Down the Hatch (2017)

    Google Scholar 

  16. Min, J., Yang, Y., Wu, Z., Gao, W.: Robotics in the gut. . Adv. Therapeutics 3(4), 1900125 (2020)

    Article  Google Scholar 

  17. Kalantar-Zadeh, K., Ward, S.A.: Future is ready for swallowable sensors. Hepato Biliary Surg. Nutr. 8(3), 267–269 (2019)

    Article  Google Scholar 

  18. Inda, M.E., Mimee, M., Lu, T.K.: Cell-based biosensors for immunology, inflammation, and allergy. J. Allergy Clin. Immunol. 144(3), 645–647 (2019)

    Article  Google Scholar 

  19. Brown, M.T., Bussell, J.K.: Medication adherence: WHO cares?. Mayo Clinic Proc. 86(4), 304–314 (2011)

    Google Scholar 

  20. Aldeer, M., Javanmard, M., Martin, R.P.: A review of medication adherence monitoring technologies. Appl. Syst. Innov. 1(2), 14 (2018)

    Article  Google Scholar 

  21. Chen, C., Zhao, X.L., Li, Z.H., Zhu, Z.G., Qian, S.H., Flewitt, A.J.: Current and emerging technology for continuous glucose monitoring. Sensors (Basal), 17(1), 182 (2017)

    Google Scholar 

  22. Kempa, M., Budrejko, S., Zienciuk-Krajka, A., Daniłowicz-Szymanowicz, L., Królak, T., Opielowska-Nowak, B., Kwiatkowska, J., Raczak, G.: Subcutaneous implantable cardioverter defibrillators for the prevention of sudden cardiac death: five‑year single-center experience. Kardiologia Polska (Polish Heart J.), 78(5), 447–450 (2020)

    Google Scholar 

  23. Kropff, J., et al.: Accuracy and longevity of an implantable continuous glucose sensor in the PRECISE study: a 180-day, prospective, multicenter, pivotal trial. Diab. Care 40(1), 63–68 (2017)

    Article  Google Scholar 

  24. Leelarathna, L., Nodale, M., Allen, J.M., Elleri, D., Kumareswaran, K., Haidar, A., Caldwell, K., Wilinska, M.E., Acerini, C.L., Evans, M.L., Murphy, H.R., Hovorka, R.: Evaluating the accuracy and large inaccuracy of two continuous glucose monitoring systems. Diab. Technol. Therapeutics, 15(2), 143–149 (2013)

    Google Scholar 

  25. Zhang, W., et al.: Self-powered implantable skin-like glucometer for real-time detection of blood glucose level in vivo. Nano-Micro Lett. 10, 32 (2018)

    Article  Google Scholar 

  26. Hammadi, A.M., Humadi, A.F., Mahmood, A.L.: New optical fiber biosensor method for glucose in serum. Mater. Sci. Eng. 745 (2020)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. International Burch University, Francuske Revolucije bb, 71 210, Ilidža, Bosnia and Herzegovina

    Neira Crnčević, Damilola M. Ajayi, Tarik Zubčević, Sara Deumić & Haris Kolić

Authors
  1. Neira Crnčević
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Damilola M. Ajayi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tarik Zubčević
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sara Deumić
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Haris Kolić
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Neira Crnčević .

Editor information

Editors and Affiliations

  1. Verlab Research Institute for Biomedical Engineering, Medical Devices, and Artificial Intelligence, Sarajevo, Bosnia and Herzegovina

    Almir Badnjević

  2. Verlab Research Institute for Biomedical Engineering, Medical Devices, and Artificial Intelligence, Sarajevo, Bosnia and Herzegovina

    Lejla Gurbeta Pokvić

Rights and permissions

Reprints and permissions

Copyright information

© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Crnčević, N., Ajayi, D.M., Zubčević, T., Deumić, S., Kolić, H. (2024). Implantable and Ingestible Biosensors. In: Badnjević, A., Gurbeta Pokvić, L. (eds) MEDICON’23 and CMBEBIH’23. MEDICON CMBEBIH 2023 2023. IFMBE Proceedings, vol 94. Springer, Cham. https://doi.org/10.1007/978-3-031-49068-2_44

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-49068-2_44

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-49067-5

  • Online ISBN: 978-3-031-49068-2

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Search

Navigation