Skip to main content
SpringerLink
Log in

Can Microneedles Revolutionize Ocular Drug Delivery?

  • Conference paper
  • First Online:
MEDICON’23 and CMBEBIH’23 (MEDICON 2023, CMBEBIH 2023)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 93))

  • 168 Accesses

Abstract

The anterior and posterior segments of the eye are extremely difficult to reach and treat, due to their barrier properties and inaccessibility of the ocular tissues. Given that traditional drug delivery systems, such as topical eye drops, or hypodermic needles, possess many disadvantages such as causing pain, and discomfort or resulting in low drug bioavailability, microneedles (MNs) are recently proposed as minimally invasive drug delivery systems for treating ocular diseases. These systems enable the localization of drugs within the ocular tissue, while on the other hand being painless. Given that MNs will definitely change how eye medication formulations are delivered in the future, this work aimed to summarize the previous studies on the potential of using microneedles as drug delivery systems for treating ocular diseases and outline the future aspect of MNs production technologies.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 299.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. He, Y., Nie, A., Pei, J., Ji, Z., Jia, J., Liu, H., et al.: Prevalence and causes of visual impairment in population more than 50 years old: the Shaanxi eye study. Medicine (Baltimore) 99, e20109 (2020)

    Google Scholar 

  2. Thakur Singh, R.R., Tekko, I., McAvoy, K., McMillan, H., Jones, D., Donnelly, R.F.: Minimally invasive microneedles for ocular drug delivery. Expert Opin. Drug Deliv. 14, 525–537 (2017)

    Article  Google Scholar 

  3. Prausnitz, M.R., Jiang, J., Patel, S.R., Gill, H.S., Ghate, D., McCarey, B.E., et al.: Ocular drug delivery using microneedles. Invest. Ophthalmol. Vis. Sci. 48, 3191 (2007)

    Google Scholar 

  4. Jamaledin, R., You, C.K.Y., Zare, E.N., Niu, L.N., Vecchione, R., Chen, G., et al.: Advances in antimicrobial microneedle patches for combating infections. Adv. Mater. 32, 1–29 (2020)

    Google Scholar 

  5. Tucak, A., Sirbubalo, M., Hindija, L., Rahić, O., Hadžiabdić, J., Muhamedagić, K., et al.: Microneedles: characteristics, materials, production methods and commercial development. Micromachines 11, 961 (2020)

    Article  Google Scholar 

  6. Thakur, R.R.S., Fallows, S.J., McMillan, H.L., Donnelly, R.F., Jones, D.S.: Microneedle-mediated intrascleral delivery of in situ forming thermoresponsive implants for sustained ocular drug delivery. J. Pharm. Pharmacol. 66, 584–595 (2014)

    Google Scholar 

  7. Khandan, O., Kahook, M.Y., Rao, M.P.: Fenestrated microneedles for ocular drug delivery. Sens. Actuators B Chem. 223, 15–23 (2016)

    Article  Google Scholar 

  8. Goyal, G., Garg, T., Rath, G., Goyal, A.K.: Current nanotechnological strategies for treating glaucoma. Crit. Rev. Ther. Drug Carrier Syst. 31, 365–405 (2014)

    Article  Google Scholar 

  9. Davis, S.P., Martanto, W., Allen, M.G., Prausnitz, M.R.: Hollow metal microneedles for insulin delivery to diabetic rats. IEEE Trans. Biomed. Eng. 52, 909–915 (2005)

    Article  Google Scholar 

  10. Martanto, W., Moore, J.S., Couse, T., Prausnitz, M.R.: Mechanism of fluid infusion during microneedle insertion and retraction. J. Control. Release 112, 357–361 (2006)

    Article  Google Scholar 

  11. Wang, P.M., Cornwell, M., Prausnitz, M.R.: Minimally invasive extraction of dermal interstitial fluid for glucose monitoring using microneedles. Diabetes Technol. Ther. 7, 131–141 (2005)

    Article  Google Scholar 

  12. Bal, S.M., Ding, Z., Van Riet, E., Jiskoot, W., Bouwstra, J.A.: Advances in transcutaneous vaccine delivery: do all ways lead to Rome? J. Control. Release 148, 266–282 (2010)

    Article  Google Scholar 

  13. Larrañeta, E., Lutton, R.E.M., Woolfson, A.D., Donnelly, R.F.: Microneedle arrays as transdermal and intradermal drug delivery systems: materials science, manufacture and commercial development. Mater. Sci. Eng. R Rep. 104, 1–32 (2016)

    Google Scholar 

  14. Rahić, O., Tucak, A., Omerović, N., Sirbubalo, M., Hindija, L., Hadžiabdić, J., et al.: Novel drug delivery systems fighting glaucoma: formulation obstacles and solutions. Pharmaceutics 13, 1–58 (2021)

    Google Scholar 

  15. Jiang, J., Gill, H.S., Ghate, D., McCarey, B.E., Patel, S.R., Edelhauser, H.F., et al.: Coated microneedles for drug delivery to the eye. Investig. Ophthalmol. Vis. Sci. 48, 4038–4043 (2007)

    Article  Google Scholar 

  16. Song, H.B., Kim, J.H., Ju, K., Seo, I.H., Lee, J.Y., Lee, S.M., et al.: Impact insertion of transfer-molded microneedle for localized and minimally invasive ocular drug delivery. J. Control. Release 209, 272–279 (2015)

    Article  Google Scholar 

  17. Jiang, J., Moore, J.S., Edelhauser, H.F., Prausnitz, M.R.: Intrascleral drug delivery to the eye using hollow microneedles. Pharm. Res. 26, 395–403 (2009)

    Article  Google Scholar 

  18. Patel, S.R., Lin, A.S.P., Edelhauser, H.F., Prausnitz, M.R.: Suprachoroidal drug delivery to the back of the eye using hollow microneedles. Pharm. Res. 28, 166–176 (2011)

    Google Scholar 

  19. Patel, S.R., Berezovsky, D.E., McCarey, B.E., Zarnitsyn, V., Edelhauser, H.F., Prausnitz, M.R.: Targeted administration into the suprachoroidal space using a microneedle for drug delivery to the posterior segment of the eye. Invest. Ophthalmol. Vis. Sci. 53, 4433–4441 (2012)

    Article  Google Scholar 

  20. Gilger, B.C., Abarca, E.M., Salmon, J.H., Patel, S.: Treatment of acute posterior uveitis in a porcine model by injection of triamcinolone acetonide into the suprachoroidal space using microneedles. Investig. Ophthalmol. Vis. Sci. 54, 2483–2492 (2013)

    Article  Google Scholar 

  21. Thakur, R.R.S., Tekko, I.A., Al-Shammari, F., Ali, A.A., McCarthy, H., Donnelly, R.F.: Rapidly dissolving polymeric microneedles for minimally invasive intraocular drug delivery. Drug Deliv. Transl. Res. 6, 800–815 (2016)

    Google Scholar 

  22. Bhatnagar, S., Saju, A., Cheerla, K.D., Gade, S.K., Garg, P., Venuganti, V.V.K.: Corneal delivery of besifloxacin using rapidly dissolving polymeric microneedles. Drug Deliv. Transl. Res. 8, 473–483 (2018)

    Google Scholar 

  23. Than, A., Liu, C., Chang, H., Duong, P.K., Cheung, C.M.G., Xu, C., et al.: Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery. Nat. Commun. 9, 4433 (2018)

    Google Scholar 

  24. Roy, G., Galigama, R.D., Thorat, V.S., Garg, P., Venuganti, V.V.K.: Microneedle ocular patch: fabrication, characterization, and ex-vivo evaluation using pilocarpine as model drug. Drug Dev. Ind. Pharm. 46, 1114–1122 (2020)

    Google Scholar 

  25. Shi, H., Zhou, J., Wang, Y., Zhu, Y., Lin, D., Lei, L., et al.: A rapid corneal healing microneedle for efficient ocular drug delivery. Small 18, 2104657 (2022)

    Article  Google Scholar 

  26. Albadr, A.A., Tekko, I.A., Vora, L.K., Ali, A.A., Laverty, G., Donnelly, R.F., et al.: Rapidly dissolving microneedle patch of amphotericin B for intracorneal fungal infections. Drug Deliv. Transl. Res. 12, 931–943 (2022)

    Article  Google Scholar 

  27. Datta, D., Roy, G., Garg, P., Venuganti, V.V.K.: Ocular delivery of cyclosporine A using dissolvable microneedle contact lens. J. Drug Deliv. Sci. Technol. 70, 103211 (2022)

    Google Scholar 

  28. Roy, G., Garg, P., Venuganti, V.V.K.: Microneedle scleral patch for minimally invasive delivery of triamcinolone to the posterior segment of eye. Int. J. Pharm. 612, 121305 (2022)

    Google Scholar 

  29. Amer, M., Ni, X., Xian, M., Chen, R.K.: Photo-responsive hydrogel microneedles with interlocking control for easy extraction in sustained ocular drug delivery. J. Eng. Sci. Med. Diagn. Ther. 5, 011001 (2022)

    Google Scholar 

  30. Sirbubalo, M., Tucak, A., Muhamedagic, K., Hindija, L., Rahić, O., Hadžiabdić, J., et al.: 3D Printing—a “touch-button” approach to manufacture microneedles for transdermal drug delivery. Pharmaceutics 13, 924 (2021)

    Article  Google Scholar 

Download references

Acknowledgment

This research has been supported by Federal Ministry of Education and Science, Bosnia and Herzegovina (project number 05-35-1928-1/21).

Author information

Authors and Affiliations

  1. Faculty of Pharmacy, Department of Pharmaceutical Technology, University of Sarajevo, Zmaja od Bosne 8, 71000, Sarajevo, Bosnia and Herzegovina

    Merima Šahinović, Amina Tucak-Smajić, Lamija Hindija, Ognjenka Rahić, Jasmina Hadžiabdić & Edina Vranić

  2. Faculty of Mechanical Engineering, Department of Machinery Production Engineering, University of Sarajevo, Vilsonovo šetalište 9, 71000, Sarajevo, Bosnia and Herzegovina

    Kenan Muhamedagić & Ahmet Čekić

Authors
  1. Merima Šahinović
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amina Tucak-Smajić
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kenan Muhamedagić
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lamija Hindija
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ognjenka Rahić
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jasmina Hadžiabdić
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Edina Vranić
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Ahmet Čekić
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Merima Šahinović .

Editor information

Editors and Affiliations

  1. Verlab Research Institute for Biomedical Engineering, Medical Devices, and Artificial Intelligence, Sarajevo, Bosnia and Herzegovina

    Almir Badnjević

  2. Verlab Research Institute for Biomedical Engineering, Medical Devices, and Artificial Intelligence, Sarajevo, Bosnia and Herzegovina

    Lejla Gurbeta Pokvić

Rights and permissions

Reprints and permissions

Copyright information

© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Šahinović, M. et al. (2024). Can Microneedles Revolutionize Ocular Drug Delivery?. In: Badnjević, A., Gurbeta Pokvić, L. (eds) MEDICON’23 and CMBEBIH’23. MEDICON CMBEBIH 2023 2023. IFMBE Proceedings, vol 93. Springer, Cham. https://doi.org/10.1007/978-3-031-49062-0_46

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-49062-0_46

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-49061-3

  • Online ISBN: 978-3-031-49062-0

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Search

Navigation