Abstract
Since 2020, breast cancer has been the one with greater incidence across the world. It is important to evaluate the possibility of the application of this minimally invasive procedure to treat the different types of premalignant lesions present in this type of cancer. Since microwave ablation therapy has been proven effective against liver and bone cancer, this research aims to assess the feasibility of an optimization method for the design of an antenna applicator that takes into consideration the effective wavelength of the breast tissue. Therefore, the computational finite element method is used to evaluate the therapy in an in-silico environment, which considers the thermodynamic, dielectric properties of the materials, modelling the response of the heat transfer in biological tissues due to microwave and the matching of the antenna. Achieving a \({\text{S}}_{11} = - 24.79{\text{ dB}}\), SAR = 25 dB, and maximum temperature of 110 ℃ for a medium fat tissue density breast model. Inserting a 14 mm of diameter sphere with the characteristics of Ductal Carcinoma In-Situ, resulted in a \({\text{S}}_{11} = - 11.47{\text{ dB}}\). Thus, not only maintaining the desired values for the coupling parameters, but also reaching greater ablation zones and temperatures with the lesion.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Zheng, K., et al.: Clinical guideline for microwave ablation of bone tumors in extremities. Orthop. Surg. 12, 1036–1044 (2020). https://doi.org/10.1111/os.12749
Radjenović, B., Sabo, M., Šoltes, L., Prnova, M., Čičak, P., Radmilović-Radjenović, M.: On efficacy of microwave ablation in the thermal treatment of an early-stage hepatocellular carcinoma. Cancers 13, 5784 (2021). https://doi.org/10.3390/cancers13225784
Brace, C.L.: Microwave tissue ablation: biophysics, technology, and applications. Crit. Rev. Biomed. Eng. 38, 65–78 (2010). https://doi.org/10.1615/CritRevBiomedEng.v38.i1.60
Etoz, S., Brace, C.L.: Analysis of microwave ablation antenna optimization techniques. Int. J. RF Microw. Comput. Aided Eng. 28, e21224 (2018). https://doi.org/10.1002/mmce.21224
Gas, P., Szymanik, B.: Shape optimization of the multi-slot coaxial antenna for local hepatic heating during microwave ablation. In: 2018 International Interdisciplinary PhD Workshop (IIPhDW), pp. 319–322. IEEE, Swinoujście (2018)
Xu, Y., Moser, M.A.J., Zhang, E., Zhang, W., Zhang, B.: Large and round ablation zones with microwave ablation: a preliminary study of an optimal aperiodic tri-slot coaxial antenna with the π-matching network section. Int. J. Therm. Sci. 140, 539–548 (2019). https://doi.org/10.1016/j.ijthermalsci.2019.03.022
Zhao, Z., Wu, F.: Minimally-invasive thermal ablation of early-stage breast cancer: a systemic review. Eur. J. Surg. Oncol. (EJSO) 36, 1149–1155 (2010). https://doi.org/10.1016/j.ejso.2010.09.012
Sung, H., et al.: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CAA Cancer J. Clin. 71, 209–249 (2021). https://doi.org/10.3322/caac.21660
Irving, J., Mario, C., Francisco, V., Geshel, G.: Microwave ablation: state-of-the-art review. OTT 1627 (2015). https://doi.org/10.2147/OTT.S81734
Krenacs, T., et al.: Modulated electro-hyperthermia-induced tumor damage mechanisms revealed in cancer models. IJMS. 21, 6270 (2020). https://doi.org/10.3390/ijms21176270
Gas, P.: Optimization of multi-slot coaxial antennas for microwave thermotherapy based on the S11-parameter analysis. Biocybern. Biomed. Eng. 37, 78–93 (2017). https://doi.org/10.1016/j.bbe.2016.10.001
Martellosio, A., et al.: Dielectric properties characterization from 0.5 to 50 GHz of breast cancer tissues. IEEE Trans. Microwave Theory Tech. 65, 998–1011 (2017). https://doi.org/10.1109/TMTT.2016.2631162
Said Camilleri, J., et al.: Review of thermal and physiological properties of human breast tissue. Sensors 22, 3894 (2022). https://doi.org/10.3390/s22103894
Segura Félix, K., et al.: Computational FEM model and phantom validation of microwave ablation for segmental microcalcifications in breasts using a coaxial double-slot antenna. Biomed. Res. Int. 2021, 1–10 (2021). https://doi.org/10.1155/2021/8858822
Balanis, C.A. (ed.): Modern Antenna Handbook. Wiley, Hoboken, NJ (2008)
Huang, Y., Boyle, K.: Antennas: From Theory to Practice. Wiley (2008)
Guerrero López, G.D., et al.: Computational FEM model, phantom and ex vivo swine breast validation of an optimized double-slot microcoaxial antenna designed for minimally invasive breast tumor ablation: theoretical and experimental comparison of temperature, size of lesion, and SWR, preliminary data. Comput. Math. Methods Med. 2017, 1–11 (2017). https://doi.org/10.1155/2017/1562869
Jesús Cepeda Rubio, M.F.: Coaxial slot antenna design for microwave hyperthermia using finite-difference time-domain and finite element method. TONMJ 3, 2–9 (2011). https://doi.org/10.2174/1875933501103010002
Ortega-Palacios, R., et al.: Feasibility of using a novel 2.45 GHz double short distance slot coaxial antenna for minimally invasive cancer breast microwave ablation therapy: computational model, phantom, and in vivo swine experimentation. J. Healthc. Eng. 2018, 1–10 (2018). https://doi.org/10.1155/2018/5806753
Rhim, H., et al.: Essential techniques for successful radio-frequency thermal ablation of malignant hepatic tumors. Radiographics 21, S17–S35 (2001). https://doi.org/10.1148/radiographics.21.suppl_1.g01oc11s17
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
García, E.P. et al. (2024). In Silico Coaxial Antenna Design Applicator Optimization for Microwave Ablation Therapy in Medium Adipose Tissue Density Breast with Ductal Carcinoma In-Situ. In: Flores Cuautle, J.d.J.A., et al. XLVI Mexican Conference on Biomedical Engineering. CNIB 2023. IFMBE Proceedings, vol 96. Springer, Cham. https://doi.org/10.1007/978-3-031-46933-6_5
Download citation
DOI: https://doi.org/10.1007/978-3-031-46933-6_5
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-46932-9
Online ISBN: 978-3-031-46933-6
eBook Packages: EngineeringEngineering (R0)