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Individualised Preventive Measurements of Suboptimal Health

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All Around Suboptimal Health

Part of the book series: Advances in Predictive, Preventive and Personalised Medicine ((APPPM,volume 18))

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Abstract

This chapter discusses the phases of the disease’s natural history, preventive strategies, and individualised prevention. Suboptimal Health Status (SHS) is defined as an intermediate physical state between health and disease, it is reversible and can predict or prevent non-communicable diseases (NCDs) before the onset of diseases. In preventive medicine, the subjective tool, Suboptimal Health Status Questionnaire-25 (SHSQ-25), which has been developed and validated as a reliable and robust health measurement, has been widely employed to evaluate Suboptimal Health Status (SHS) in five domains: cardiovascular system, digestive system, fatigue, immune system, and mental status. Moreover, immunoglobulin G (IgG) N-glycan patterns are suggested as one of the ideal objective measures for detecting SHS as glycosylation plays a crucial role in the inflammatory processing at the molecular level. Therefore, in order to present a deep understanding of the prevention approaches of SHS, this chapter indicates six case studies for effectively preventing the SHS defined by both subjective and objective measurements.

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Abbreviations

ADCC:

Antibody-dependent cellular cytotoxicity

BMI:

Body mass index

CH2:

Constant heavy 2

E2:

Estradiol

Fc:

Fragment crystallisable

FcyRIIB:

Fc gamma receptor type IIB

FSH:

Follicle-stimulating hormone

GlcNAc:

N-acetylglucosamine

IgG:

Immunoglobulin G

LH:

Luteinising hormone

MBL:

Mannose-binding lectin

NCDs:

Non-communicable chronic diseases

PPPM/3PM:

Predictive, preventive, and personalised medicine

PTM:

Post-translational modification

RCT:

Randomised controlled trial

SHS:

Suboptimal health status

SHSQ-25:

Suboptimal Health Status Questionnaire-25

TNF-α:

Tumour necrosis factor alpha

WHO:

World Health Organization

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Authors and Affiliations

  1. Centre for Precision Health, Edith Cowan University, Perth, WA, Australia

    Zheng Guo & Yulu Zheng

  2. School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia

    Manshu Song

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  1. Zheng Guo
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  2. Yulu Zheng
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Correspondence to Manshu Song .

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  1. Centre for Precision Health, Edith Cowan University, Perth, Australia

    Wei Wang

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Guo, Z., Zheng, Y., Song, M. (2024). Individualised Preventive Measurements of Suboptimal Health. In: Wang, W. (eds) All Around Suboptimal Health . Advances in Predictive, Preventive and Personalised Medicine, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-031-46891-9_11

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