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Salivary Gland

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Non-Neoplastic Cytology
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Abstract

Salivary gland parenchymal cells consist of ductal, acini, myoepithelial, and basal cells. Different types of neoplastic processes arise from these cell types, making it important to understand the normal cytomorphology of the salivary gland to differentiate a nonneoplastic process from a neoplastic process. This chapter describes the cytomorphology of normal salivary glands, emphasizing nonneoplastic salivary gland lesions and their differential diagnosis.

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References

  1. Holmberg KV, Hoffman MP. Anatomy, biogenesis and regeneration of salivary glands. Monogr Oral Sci. 2014;24:1–13.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Bialek EJ, Jakubowski W, Zajkowski P, Szopinski KT, Osmolski A. US of the major salivary glands: anatomy and spatial relationships, pathologic conditions, and pitfalls. Radiographics. 2006;26(3):745–63.

    Article  PubMed  Google Scholar 

  3. Raghavan V, Moorthy PE, Srinivasan S. Salivary gland Choristoma in external Auditory Canal: a case report. Fetal Pediatr Pathol. 2022;5:1–4.

    Google Scholar 

  4. Morimoto N, Ogawa K, Kanzaki J. Salivary gland choristoma in the middle ear: a case report. Am J Otolaryngol. 1999;20(4):232–5.

    Article  CAS  PubMed  Google Scholar 

  5. Dorman M, Pierse D. Ectopic salivary gland tissue in the anterior mandible: a case report. Br Dent J. 2002;193(10):571–2.

    Article  CAS  PubMed  Google Scholar 

  6. Iglesias P, Fernández-Mateos C, Tejerina E. Symptomatic salivary gland choristoma of the pituitary gland. Endocrinol Diabetes Nutr (Engl Ed). 2022;69(7):544–6.

    PubMed  Google Scholar 

  7. Stefanits H, Matula C, Frischer JM, Furtner J, Hainfellner JA, Woehrer A. Innervated ectopic salivary gland associated with Rathke's cleft cyst clinically mimicking pituitary adenoma. Clin Neuropathol. 2013;32(3):171–5.

    Article  PubMed  Google Scholar 

  8. Curry B, Taylor CW, Fisher AW. Salivary gland heterotopia: a unique cerebellopontine angle tumor. Arch Pathol Lab Med. 1982;106(1):35–8.

    CAS  PubMed  Google Scholar 

  9. Haemel A, Gnepp DR, Carlsten J, Robinson-Bostom L. Heterotopic salivary gland tissue in the neck. J Am Acad Dermatol. 2008;58(2):251–6.

    Article  PubMed  Google Scholar 

  10. Edwards PC, Bhuiya T, Kahn LB, Fantasia JE. Salivary heterotopia of the parathyroid gland: a report of two cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99(5):590–3.

    Article  PubMed  Google Scholar 

  11. Carney JA. Salivary heterotopia, cysts, and the parathyroid gland: branchial pouch derivatives and remnants. Am J Surg Pathol. 2000;24(6):837–45.

    Article  CAS  PubMed  Google Scholar 

  12. Cameselle-Teijeiro J, Varela-Durån J. Intrathyroid salivary gland-type tissue in multinodular goiter. Virchows Arch. 1994;425(3):331–4.

    Article  CAS  PubMed  Google Scholar 

  13. Maffini F, Pisa E, Possanzini P, Viale G. Salivary gland choristoma of breast. Breast J. 2012;18(2):181.

    Article  PubMed  Google Scholar 

  14. Shin CE, Kim SS, Chwals WJ. Salivary gland choristoma of the anterior chest wall. J Pediatr Surg. 2000;35(10):1506–7.

    Article  CAS  PubMed  Google Scholar 

  15. Feigin GA, Robinson B, Marchevsky A. Mixed tumor of the mediastinum. Arch Pathol Lab Med. 1986;110(1):80–1.

    CAS  PubMed  Google Scholar 

  16. Ryu DG, Choi CW, Kim SJ. Esophageal wall thickening due to salivary gland heterotopia. Korean J Intern Med. 2022;38:139.

    Google Scholar 

  17. Abdul Karim L, Kwon DH, Ozdemirli M. Salivary gland heterotopia in the gastroesophageal junction: a case series and review of the literature. Case Rep Gastrointest Med. 2018;30(2018):6078581.

    Google Scholar 

  18. Maffini F, Vingiani A, Lepanto D, Fiori G, Viale G. Salivary gland choristoma in large bowel. Endoscopy. 2012;44(Suppl 2 UCTN):E13–4.

    PubMed  Google Scholar 

  19. Lewis AL, Truong LD, Cagle P, Zhai QJ. Benign salivary gland tissue inclusion in a pulmonary hilar lymph node from a patient with invasive well-differentiated adenocarcinoma of the lung: a potential misinterpretation for the staging of carcinoma. Int J Surg Pathol. 2011;19(3):382–5.

    Article  PubMed  Google Scholar 

  20. Shinohara M, Harada T, Nakamura S, Oka M, Tashiro H. Heterotopic salivary gland tissue in lymph nodes of the cervical region. Int J Oral Maxillofac Surg. 1992;21(3):166–71.

    Google Scholar 

  21. Gnepp DR, Brannon R. Sebaceous neoplasms of salivary gland origin. Report of 21 cases. Cancer. 1984;53(10):2155–70.

    Article  CAS  PubMed  Google Scholar 

  22. Nagao T, Sato E, Inoue R, Oshiro H, Takahashi RH, Nagai T, Yoshida M, Suzuki F, Obikane H, Yamashina M, Matsubayashi J. Immunohistochemical analysis of salivary gland tumors: application for surgical pathology practice. Acta Histochem Cytochem. 2012;45(5):269–82.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Furuse C, Sousa SO, Nunes FD, Magalhães MH, Araújo VC. Myoepithelial cell markers in salivary gland neoplasms. Int J Surg Pathol. 2005;13(1):57–65.

    Article  CAS  PubMed  Google Scholar 

  24. Hsieh MS, Lee YH, Chang YL. SOX10-positive salivary gland tumors: a growing list, including mammary analogue secretory carcinoma of the salivary gland, sialoblastoma, low-grade salivary duct carcinoma, basal cell adenoma/adenocarcinoma, and a subgroup of mucoepidermoid carcinoma. Hum Pathol. 2016;56:134–42.

    Article  CAS  PubMed  Google Scholar 

  25. Chênevert J, Duvvuri U, Chiosea S, Dacic S, Cieply K, Kim J, Shiwarski D, Seethala RR. DOG1: a novel marker of salivary acinar and intercalated duct differentiation. Mod Pathol. 2012;25(7):919–29.

    Article  PubMed  Google Scholar 

  26. Stojanov IJ, Malik UA, Woo SB. Intraoral salivary duct cyst: clinical and histopathologic features of 177 cases. Head Neck Pathol. 2017;11(4):469–76.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Layfield LJ, Gopez EV. Cystic lesions of the salivary glands: cytologic features in fine-needle aspiration biopsies. Diagn Cytopathol. 2002;27(4):197–204.

    Article  PubMed  Google Scholar 

  28. Bowers EMR, Schaitkin B. Management of Mucoceles, Sialoceles, and Ranulas. Otolaryngol Clin N Am. 2021;54(3):543–51.

    Article  Google Scholar 

  29. Ozcan KM, Dere H, Ozcan I, Gun T, Unal T. An epidermal cyst in the parotid gland following ear surgery: a case report. B-ENT. 2006;2(4):193–5.

    CAS  PubMed  Google Scholar 

  30. Puxeddu I, Capecchi R, Carta F, Tavoni AG, Migliorini P, Puxeddu R. Salivary gland pathology in IgG4-related disease: a comprehensive review. J Immunol Res. 2018;2018:6936727.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Migliora P, Barizzi J, Torre A, Ermanni S, Fulciniti F. A hard mass of the right submandibular gland in an 83-Yr-old lady. Acta Cytol. 2021;65(2):194–6.

    Article  PubMed  Google Scholar 

  32. Umehara H, Okazaki K, Nakamura T, Satoh-Nakamura T, Nakajima A, Kawano M, Mimori T, Chiba T. Current approach to the diagnosis of IgG4-related disease - combination of comprehensive diagnostic and organ-specific criteria. Mod Rheumatol. 2017;27(3):381–91.

    Article  CAS  PubMed  Google Scholar 

  33. Ojha J, Rawal YB, Hornick JL, Magliocca K, Montgomery DR, Foss RD, Torske KR, Accurso B. Extra nodal Rosai-Dorfman disease originating in the nasal and paranasal complex and gnathic bones: a systematic analysis of seven cases and review of literature. Head Neck Pathol. 2020;14(2):442–53.

    Article  PubMed  Google Scholar 

  34. Ravindran A, Goyal G, Go RS, Rech KL. Mayo Clinic Histiocytosis working group. Rosai-Dorfman disease displays a unique monocyte-macrophage phenotype characterized by expression of OCT2. Am J Surg Pathol. 2021;45(1):35–44.

    Article  PubMed  Google Scholar 

  35. Chateaubriand SL, de Amorim Carvalho EJ, Leite AA, da Silva Leonel ACL, Prado JD, da Cruz Perez DE. Necrotizing sialometaplasia: A diagnostic challenge. Oral Oncol. 2021;118:105349.

    Article  PubMed  Google Scholar 

  36. Mukunyadzi P, Bardales RH, Palmer HE, Stanley MW. Tissue effects of salivary gland fine-needle aspiration. Does this procedure preclude accurate histologic diagnosis? Am J Clin Pathol. 2000;114(5):741–5.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Syed M. Gilani .

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Gilani, S.M. (2023). Salivary Gland. In: Gilani, S.M., Cai, G. (eds) Non-Neoplastic Cytology. Springer, Cham. https://doi.org/10.1007/978-3-031-44289-6_6

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  • DOI: https://doi.org/10.1007/978-3-031-44289-6_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-44288-9

  • Online ISBN: 978-3-031-44289-6

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