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Hydrogen Sulfide Against Ischemia-Reperfusion Injury in Transplantation of Kidney and Other Transplantable Solid Organs

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Hydrogen Sulfide in Kidney Diseases

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Abstract

Ischemia-reperfusion injury (IRI) is an unavoidable and unresolved problem that poses a great challenge in kidney transplantation. It represents a major factor that increases acute tubular necrosis, decreases graft survival, and delays renal graft function. This complicates graft quality, posttransplant patient care, and kidney transplantation outcomes and therefore undermines the success of kidney transplantation. In this chapter, we present recent advances in research regarding novel pharmacological strategies involving the use of hydrogen sulfide (H2S), the third established member of the gasotransmitter family, against IRI in different experimental models of involving transplantation of kidney and other transplantable solid organs. Additionally, we also discuss the molecular mechanisms underlying the effects of H2S donor molecules in transplantation and suggestions for clinical translation. Our findings in this chapter showed that storage of renal graft and other solid organ grafts in H2S-supplemented preservation solution or administration of H2S to organ donor prior to organ procurement and to recipient at the start and during reperfusion is a novel, simple, and cost-effective pharmacological approach to minimize cold IRI, limit posttransplant complications, and improve transplantation outcomes. In conclusion, experimental evidence demonstrates that H2S can significantly mitigate IRI during transplantation through inhibition of a complex cascade of interconnected cellular and molecular events involving microcirculatory disturbance and microvascular dysfunction, mitochondrial injury, inflammatory responses, cell damage and cell death, and other damaging molecular pathways while promoting protective pathways. Translating these promising findings from bench to bedside will lay the foundation for the use of H2S in clinical organ transplantation in the future.

This chapter is a modified version by the same authors in the publication titled H2S donor molecules against cold ischemia-reperfusion injury in preclinical models of solid organ transplantation. Pharmacol Res. 2021 Oct; 172:105842.

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Authors and Affiliations

  1. Division of Urology, Department of Surgery, London Health Sciences Center, Western University, London, ON, Canada

    George J. Dugbartey & Alp Sener

  2. Multi-Organ Transplant Program, London Health Sciences Center, Western University, London, ON, Canada

    George J. Dugbartey & Alp Sener

  3. Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, ON, Canada

    George J. Dugbartey & Alp Sener

  4. Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Accra, Ghana

    George J. Dugbartey

  5. Department of Physiology and Pharmacology, Accra College of Medicine, Accra, Ghana

    George J. Dugbartey

  6. Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada

    Alp Sener

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  1. George J. Dugbartey
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  2. Alp Sener
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Correspondence to George J. Dugbartey .

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Dugbartey, G.J., Sener, A. (2023). Hydrogen Sulfide Against Ischemia-Reperfusion Injury in Transplantation of Kidney and Other Transplantable Solid Organs. In: Hydrogen Sulfide in Kidney Diseases. Springer, Cham. https://doi.org/10.1007/978-3-031-44041-0_9

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  • DOI: https://doi.org/10.1007/978-3-031-44041-0_9

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