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Metabolomics Applied to Cyanobacterial Toxins and Natural Products

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Microbial Natural Products Chemistry

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1439))

Abstract

The biological and chemical diversity of Cyanobacteria is remarkable. These ancient prokaryotes are widespread in nature and can be found in virtually every habitat on Earth where there is light and water. They are producers of an array of secondary metabolites with important ecological roles, toxic effects, and biotechnological applications. The investigation of cyanobacterial metabolites has benefited from advances in analytical tools and bioinformatics that are employed in metabolomic analyses. In this chapter, we review selected articles highlighting the use of targeted and untargeted metabolomics in the analyses of secondary metabolites produced by cyanobacteria. Here, cyanobacterial secondary metabolites have been didactically divided into toxins and natural products according to their relevance to toxicological studies and drug discovery, respectively. This review illustrates how metabolomics has improved the chemical analysis of cyanobacteria in terms of speed, sensitivity, selectivity, and/or coverage, allowing for broader and more complex scientific questions.

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Author notes

  1. Authors M. B. Weiss and R. V. Médice have equally contributed to this chapter.

Authors and Affiliations

  1. School of Pharmaceutical Sciences, Department of Biochemical and Pharmaceutical Technology, University of São Paulo, São Paulo, Brazil

    Márcio Barczyszyn Weiss & Camila Manoel Crnkovic

  2. School of Pharmaceutical Sciences, Department of Clinical and Toxicological Analyses, University of São Paulo, São Paulo, Brazil

    Rhuana Valdetário Médice & Fernanda Rios Jacinavicius

  3. Centre for Nuclear Energy in Agriculture, Division of Tropical Ecosystem Functioning, University of São Paulo, Piracicaba, Brazil

    Ernani Pinto

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Correspondence to Camila Manoel Crnkovic .

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  1. Institute of Chemistry, Universidade Estadual de Campinas, Campinas, Brazil

    Taícia Pacheco Fill

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Weiss, M.B., Médice, R.V., Jacinavicius, F.R., Pinto, E., Crnkovic, C.M. (2023). Metabolomics Applied to Cyanobacterial Toxins and Natural Products. In: Pacheco Fill, T. (eds) Microbial Natural Products Chemistry. Advances in Experimental Medicine and Biology(), vol 1439. Springer, Cham. https://doi.org/10.1007/978-3-031-41741-2_2

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