Skip to main content

Clinical Manifestations of Early Disseminated Lyme Carditis

  • Chapter
  • First Online:
Lyme Carditis

Abstract

Atrioventricular conduction abnormalities are the most common presentation of early disseminated Lyme carditis. Up to two-thirds of patients with Lyme carditis will progress to a high-degree atrioventricular block; however, it can reverse completely when early antibiotic treatment is provided. A systematic approach to early disseminated Lyme carditis is essential since the identification of Lyme as the etiology in patients with heart block will avoid the unnecessary implantation of permanent pacemakers. This chapter covers the clinical manifestation of early disseminated Lyme carditis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Yeung C, Baranchuk A. Diagnosis and treatment of Lyme Carditis: JACC review topic of the week. J Am Coll Cardiol. 2019;73(6):717–26.

    Article  PubMed  Google Scholar 

  2. Centers for Disease Control and Prevention. Lyme disease: data and surveillance. 2022 [cited 2022 Nov 11]. Available from: www.cdc.gov/lyme/stats/index.html.

  3. Public Health Agency of Canada. Surveillance of Lyme disease. 2022 [cited 2022 Nov 11]. Available from: https://www.canada.ca/en/public-health/services/diseases/lyme-disease/surveillance-lyme-disease.html.

  4. Ripoche M, Gasmi S, Adam-Poupart A, Koffi JK, Lindsay LR, Ludwig A, et al. Passive tick surveillance provides an accurate early signal of emerging Lyme disease risk and human cases in Southern Canada. J Med Entomol. 2018;55(4):1016–26.

    Article  PubMed  Google Scholar 

  5. Shen RV, McCarthy CA, Smith RP. Lyme Carditis in hospitalized children and adults, a case series. Open Forum Infect Dis. 2021;8(7):ofab140.

    Google Scholar 

  6. Robinson ML, Kobayashi T, Higgins Y, Calkins H, Melia MT. Lyme carditis. Infect Dis Clin North Am. 2015;29(2):255–68.

    Article  PubMed  Google Scholar 

  7. Montgomery RR, Booth CJ, Wang X, Blaho VA, Malawista SE, Brown CR. Recruitment of macrophages and polymorphonuclear leukocytes in Lyme carditis. Infect Immun. 2007;75(2):613–20.

    Article  CAS  PubMed  Google Scholar 

  8. Raveche ES, Schutzer SE, Fernandes H, Bateman H, McCarthy BA, Nickell SP, et al. Evidence of Borrelia autoimmunity-induced component of Lyme carditis and arthritis. J Clin Microbiol. 2005;43(2):850–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Krause PJ, Bockenstedt LK. Cardiology patient pages. Lyme disease and the heart. Circulation. 2013;127(7):e451–4.

    Article  PubMed  Google Scholar 

  10. Uzomah UA, Rozen G, Mohammadreza Hosseini S, Shaqdan A, Ledesma PA, Yu X, et al. Incidence of carditis and predictors of pacemaker implantation in patients hospitalized with Lyme disease. PLoS ONE. 2021;16(11):e0259123.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. van der Linde MR. Lyme carditis: clinical characteristics of 105 cases. Scand J Infect Dis Suppl. 1991;77:81–4.

    PubMed  Google Scholar 

  12. Wang CN, Yeung C, Enriquez A, Chacko S, Hanson S, Redfearn D, et al. Long-term outcomes in treated Lyme Carditis. Curr Probl Cardiol. 2022;47(10):100939.

    Article  PubMed  Google Scholar 

  13. Fatima B, Sohail MR, Schaff HV. Lyme disease-an unusual cause of a mitral valve endocarditis. Mayo Clin Proc Innov Qual Outcomes. 2018;2(4):398–401.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Duray PH. Histopathology of clinical phases of human Lyme disease. Rheum Dis Clin North Am. 1989;15(4):691–710.

    Article  CAS  PubMed  Google Scholar 

  15. Besant G, Wan D, Yeung C, Blakely C, Branscombe P, Suarez-Fuster L, et al. Suspicious index in Lyme carditis: systematic review and proposed new risk score. Clin Cardiol. 2018;41(12):1611–6.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Yeung C, Baranchuk A. Systematic approach to the diagnosis and treatment of Lyme Carditis and high-degree atrioventricular block. Healthcare (Basel). 2018;6(4).

    Google Scholar 

  17. Munk PS, Orn S, Larsen AI. Lyme carditis: persistent local delayed enhancement by cardiac magnetic resonance imaging. Int J Cardiol. 2007;115(3):e108–10.

    Article  PubMed  Google Scholar 

  18. Stanek G, Wormser GP, Gray J, Strle F. Lyme borreliosis. Lancet. 2012;379(9814):461–73.

    Article  PubMed  Google Scholar 

  19. Motamed M, Liblik K, Miranda-Arboleda AF, Wamboldt R, Wang CN, Cingolani O, et al. Disseminated Lyme disease and dilated cardiomyopathy: a systematic review. Trends Cardiovasc Med. 2022.

    Google Scholar 

  20. Wamboldt R, Wang CN, Miller JC, Enriquez A, Yeung C, Chacko S, et al. Pacemaker explanation in patients with Lyme Carditis. JACC Case Rep. 2022;4(10):613–6.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Muehlenbachs A, Bollweg BC, Schulz TJ, Forrester JD, DeLeon CM, Molins C, et al. Cardiac tropism of Borrelia burgdorferi: an autopsy study of sudden cardiac death associated with Lyme Carditis. Am J Pathol. 2016;186(5):1195–205.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Andres F. Miranda-Arboleda .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Miranda-Arboleda, A.F., Sierra-David, J.G., Wamboldt, R., Baranchuk, A. (2023). Clinical Manifestations of Early Disseminated Lyme Carditis. In: Baranchuk, A., Wamboldt, R., Wang, C.N. (eds) Lyme Carditis. Springer, Cham. https://doi.org/10.1007/978-3-031-41169-4_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-41169-4_6

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-41168-7

  • Online ISBN: 978-3-031-41169-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics