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Vaccination Policies in Otitis Media

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Textbook of Otitis Media

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Abstract

Otitis media is a multifaceted entity, why a single vaccination against otitis media is not possible. Vaccination against pneumococci and Haemophilus influenzae type b (Hib) has, however, changed the epidemiology of acute otitis media (AOM) in children. The effect on serous otitis media (SOM) has been less pronounced. Viral vaccinations might also affect the epidemiology of otitis media. This is both by preventing otitis media caused by the virus but also and perhaps more importantly by preventing the facilitating of bacterial infections during viral upper airway infections.

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References

  1. Centers for Disease Control and Prevention. Progress toward elimination of Haemophilus influenza type b invasive disease among infants and children—United States, 1998–2000. MMWR Morb Mortal Wkly Rep. 2002;51:234–7.

    Google Scholar 

  2. Marom T, Nokso-Koivisto J, Chonmaitree T. Viral-bacterial interactions in acute otitis media. Curr Allergy Asthma Rep. 2012;12(6):551–8. https://doi.org/10.1007/s11882-012-0303-2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Giebink GS, Berzins IK, Marker SC, Schiffman G. Experimental otitis media after nasal inoculation of Streptococcus pneumoniae and influenza A virus in chinchillas. Infect Immun. 1980;30(2):445–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Murphy T. Vaccines for Nontypeable Haemophilus influenzae: the future is now. Clin Vaccine Immunol. 2015;22(5):459–66.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Eskola J, Kilpi T, Palm A, Jokinen J, Haapakoski J, Herva E, Takala A, Käyhty H, Karma P, Kohberger R, Siber G, Mäkelä PH, Finnish Otitis Media Study Group. Efficacy of a pneumococcal conjugate vaccine against acute otitis media. N Engl J Med. 2001;344(6):403–9.

    Article  CAS  PubMed  Google Scholar 

  6. Black S, Shinefield H, Fireman B, et al. Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Pediatr Infect Dis. 2000;19:187–95.

    Article  CAS  Google Scholar 

  7. Straetemans M, Sanders EA, Veenhoven RH, Schilder AG, Damoiseaux RA, Zielhuis GA. Pneumococcal vaccines for preventing otitis media. Cochrane Database Syst Rev. 2002;(2):CD001480.

    Google Scholar 

  8. Gisselsson-Solén M, Melhus A, Hermansson A. Pneumococcal vaccination in children at risk of developing recurrent acute otitis media - a randomized study. Acta Paediatr. 2011;100(10):1354–8.

    Article  PubMed  Google Scholar 

  9. Prymula R, Peeters P, Chrobok V, Kriz P, Novakova E, Kaliskova E, Kohl I, Lommel P, Poolman J, Prieels JP, Schuerman L. Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typeable Haemophilus influenzae: a randomised double-blind efficacy study. Lancet. 2006;367:740–74.

    Article  CAS  PubMed  Google Scholar 

  10. Janson H, Melhus A, Hermansson A, Forsgren A. Protein D the glycerophospodiester phosphodiesterase from Haemophilus influenzae with affinity for human immunoglobulin D, influences virulence in a rat otitis model. Infect Immun. 1994;62(11):4848–54.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Chonmaitree T, Revai K, Grady JJ, Clos A, Patel JA, Nair S, Fan J, Henrickson KJ. Viral upper respiratory tract infection and otitis media complication in young children. Clin Infect Dis. 2008;46:815–23.

    Article  PubMed  Google Scholar 

  12. Heikkinen T, Ruuskanen O, Waris M, Ziegler T, Arola M, Halonen P. Influenza vaccination in the prevention of acute otitis media in children. Am J Dis Child. 1991;145(4):445–8.

    CAS  PubMed  Google Scholar 

  13. Heikkinen T, Block SL, Toback SL, Wu X, Ambrose CS. Effectiveness of intranasal live attenuated influenza vaccine against all-cause acute otitis media in children. Pediatr Infect Dis J. 2013;32(6):669–74.

    Article  PubMed  Google Scholar 

  14. Vojtek I, Nordgren M, Hoet B. Impact of pneumococcal conjugate vaccines on otitis media: a review of measurement and interpretation challenges. Int J Pediatr Otorhinolaryngol. 2017;100:174–82.

    Article  PubMed  Google Scholar 

  15. Venekamp R, Sanders S, Glasziou P, Del Mar C, Rovers M. Antibiotics for acute otitis media in children. Cochrane Database Syst Rev. 2015;23(6):CD000219.

    Google Scholar 

  16. Molstad S, Erntell M, Hanberger H, Melander E, Norman C, Skoog G, et al. Sustained reduction of antibiotic use and low bacterial resistance: 10-year follow-up of the Swedish Strama programme. Lancet Infect Dis. 2008;8(2):125–32.

    Article  CAS  PubMed  Google Scholar 

  17. Marom T, Tan A, Wilkinson GS, Pierson KS, Freeman JL, Chonmaitree T. Trends in otitis media-related health care use in the United States, 2001–2011. JAMA Pediatr. 2014;168:68–75.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Kaplan S, Center KJ, Barson WJ, Ling-Lin P, Romero JR, Bradley JS, Tan TQ, Hoffman JA, Peters TR, Gurtman A, Scott DA, Trammel J, Gruber WC, Hulten KG, Mason EO. Multicentre surveillance of Streptococcus pneumoniae isolates from middle ear and mastoid cultures in the 13-valent pneumococcal conjugate vaccine era. Clin Infect Dis. 2015;60:1339–45.

    PubMed  Google Scholar 

  19. Groth A, Enoksson F, Hermansson A, Hultcrantz M, Stalfors J, Stenfeldt K. Acute mastoiditis in children in Sweden 1993–2007—no increase after new guidelines. Int J Pediatr Otorhinolaryngol. 2011;75(12):1496–501.

    Article  PubMed  Google Scholar 

  20. Balsamo C, Biagi C, Mancini M, Corsini I, Bergamaschi R, Lanari M. Acute mastoiditis in an Italian pediatric tertiary medical center: a 15—year retrospective study. Ital J Pediatr. 2018;44(1):71.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Leach AJ, Wigger C, Hare K, Hampton V, Beissbarth J, Andrews R, Chatfield M, Smith-Vaughan H, Morris PS. Reduced middle ear infection with non-typeable Haemophilus influenzae, but not Streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine. BMC Pediatr. 2015;15:162.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Toizumi M, et al. Effect of pneumococcal conjugate vaccine on prevalence of otitis media with effusion among children in Vietnam. Vaccine. 2022;40(36):5366–75.

    Article  PubMed  Google Scholar 

  23. Jespersen SI, Demant MN, Pedersen ML, Homøe P. Acute otitis media and pneumococcal vaccination—an observational cross-sectional study of otitis media among vaccinated and unvaccinated children in Greenland. Int J Circumpolar Health. 2021;80(1):1858615.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Briles DE, Paton JC, Mukerji R, Swiatlo E, Crain MJ. Pneumococcal vaccines. Microbiol Spectr. 2019;7(6)

    Google Scholar 

  25. Musher DM, Anderson R, Feldman C. The remarkable history of pneumococcal vaccination: an ongoing challenge Pneumonia (Nathan). 2022;14(1):5.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of ENT, Lund University Hospital, Lund, Sweden

    Ann Hermansson

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  1. Ann Hermansson
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Correspondence to Ann Hermansson .

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Editors and Affiliations

  1. Department of Otolaryngology, Clínica Universidad de Los Andes, Santiago, Chile, USA

    Marcos V. Goycoolea

  2. Otolaryngology, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Sady Selaimen da Costa

  3. Department of Otolaryngology, Tata Memorial Hospital, Mumbai, Maharashtra, India

    Chris de Souza

  4. Paparella Ear Head & Neck Institute, University of Minnesota, Minneapolis, MN, USA

    Michael M. Paparella

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Hermansson, A. (2023). Vaccination Policies in Otitis Media. In: Goycoolea, M.V., Selaimen da Costa, S., de Souza, C., Paparella, M.M. (eds) Textbook of Otitis Media. Springer, Cham. https://doi.org/10.1007/978-3-031-40949-3_26

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  • DOI: https://doi.org/10.1007/978-3-031-40949-3_26

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-40948-6

  • Online ISBN: 978-3-031-40949-3

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