Abstract
Ferroptosis, which occurs due to the peroxidation of unsaturated lipids, is associated with several pathological conditions. The fate of a ferroptotic cell is determined by the extent of damage and repair of biological membranes. In recent years, it has been discovered that multiple organelles are involved in regulating intracellular signaling pathways that either promote or inhibit ferroptosis. This chapter is dedicated to discussing the regulation of ferroptosis by various organelles, such as mitochondria, lipid droplets, endoplasmic reticulum, lysosomes, ribosomes, peroxisomes, and the Golgi apparatus. Given the crucial role of lipid peroxidation in this process, we emphasize the importance of various cellular events, including ROS production, antioxidant systems, iron metabolism, and lipid metabolism, in different organelles.
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Chen, X. (2023). Organelle-specific Mechanisms of Ferroptosis. In: Tang, D. (eds) Ferroptosis in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-031-39171-2_12
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