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Sensing Renal Nerve Activity Before, During and After Denervation: SyMap

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Renal Denervation

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Abstract

The safety and efficacy of renal denervation (RDN) for the treatment of hypertension have been repeatedly confirmed by several studies. However, an approximately 30% non-responder rate was consistently observed among various energy-based RDN concepts. This phenomenon might result from non-selective, global RDN. In this context, it is important to mention that different nerve types are located surrounding the renal artery some of which may cause a blood pressure increase but others may have no impact on the blood pressure or even cause a blood pressure reduction. Hence, depending on the nerve type injured during denervation, favorable, neutral or detrimental effects on blood pressure may be the consequence. Thus, mapping renal nerves before denervation to identify areas of denervation that may be more likely associated with a blood pressure reduction and selective sympathetic denervation followed by repeat mapping after denervation to determine if therapy has been successful is an urgent/unmet clinical need. Results of recent studies demonstrated anatomical, physiological and histological evidence to support a concept of renal electronic stimulation as a tool for renal mapping and selective denervation. Using renal stimulation, we should be able to identify proper sites for RDN, monitor the effects of RDN and confirm an effective RDN before, during and after the procedure, respectively. With a newly developed renal mapping/selective denervation system, we are conducting a pivotal trial to test the safety and efficacy of selective renal sympathetic denervation to treat uncontrolled hypertension.

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Author information

Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, College of Physicians & Surgeons, Columbia University, New York, NY, USA

    Jie Wang

  2. Academy of Clinical and Translational Research, Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China

    Jie Wang & Yue Wang

  3. SyMap Medical (Suzhou), Ltd., Suzhou, China

    Jie Wang & Yue Wang

  4. Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

    Yue-Hui Yin & Weijie Chen

  5. Department of Cardiology, Peking University First Hospital, Beijing, China

    Wei Ma

Authors
  1. Jie Wang
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  2. Yue-Hui Yin
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  3. Yue Wang
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  4. Wei Ma
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  5. Weijie Chen
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Corresponding author

Correspondence to Jie Wang .

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Editors and Affiliations

  1. University of Arizona, Phoenix, AZ, USA

    Richard R. Heuser

  2. Dobeny Hypertension Centre, Royal Perth Hospital, University of Western Australia, Perth, WA, Australia

    Markus P. Schlaich

  3. Department of Hypertension and Diabetology, Medical University of Gdańsk, Gdańsk, Poland

    Dagmara Hering

  4. Cardio Vasculäres Centrum Frankfurt, Frankfurt, Germany

    Stefan C. Bertog

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J. Wang is a co-founder of SyMap Medical (Suzhou), Ltd., China.

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Wang, J., Yin, YH., Wang, Y., Ma, W., Chen, W. (2023). Sensing Renal Nerve Activity Before, During and After Denervation: SyMap. In: Heuser, R.R., Schlaich, M.P., Hering, D., Bertog, S.C. (eds) Renal Denervation. Springer, Cham. https://doi.org/10.1007/978-3-031-38934-4_18

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  • DOI: https://doi.org/10.1007/978-3-031-38934-4_18

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-38933-7

  • Online ISBN: 978-3-031-38934-4

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