Abstract
Tissue engineering can be improved by the addition of molecules – therapeutic drugs, growth factors, cellular signaling, or binding molecules – that will facilitate cellular function and tissue regeneration. With that in mind, researchers have been exploring methods to have a better control over the release profile of drugs in order to enhance the speed, quantity, and quality of tissue regeneration. The addition of therapeutics in the scaffold can accelerate tissue regeneration process and offer the drug directly to the injured site, avoiding systemic effects. Drug delivery systems (DDS) also reduce the necessary dose to obtain the desired effect and amount of drugs needed to counter-effect adverse reactions. Hydrogels are among the most used materials for drug delivery systems (DDS). Hydrogels’ DDSs main issue is that they usually display a burst release in the beginning, and drug load hardly lasts beyond a week. However, it is possible to promote a better control over drug release profile through the method of drug loading, hydrogel cross-linking, and even chemical or physical modifications to the surface of the material.
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16 December 2023
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M.A. Sabino wants to thank FAPESP for the grant (# 2021/13949-5) as a visiting researcher at the CTI Renato Archer and the financial support of the CNPq/PCI program through the K. F. Nascimento fellowship. Amanda C Juraski would like to thank CNPq for grant #140574/2019-0.
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Malmonge, S.M., Daguano, J.K.B., Juraski, A.C., Ferreira, K.d.N., Gutierrez, M.A.S. (2023). Natural Hydrogels for Drug Delivery Systems. In: Lombello, C.B., da Ana, P.A. (eds) Current Trends in Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-031-38743-2_9
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