Skip to main content
SpringerLink
Log in

Lyme Disease and Hearing Loss in Children

  • Chapter
  • First Online:
Hearing Loss in Congenital, Neonatal and Childhood Infections

Part of the book series: Comprehensive ENT ((CENT))

  • 201 Accesses

Abstract

Lyme disease is the disease most frequently transmitted by a vector in the USA. It affects multiple body systems, and the pathogenesis involves infection by the Borrelia burgdorferi spirochaete combined with how the immune system responds to the infection [1]. The spirochaete is introduced into the human body when a tick of the genus Ixodes punctures the skin of the patient [36].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Feder HM Jr. Lyme disease in children. Infect Dis Clin N Am. 2008;22(2):315–26.

    Article  Google Scholar 

  2. Meyerhoff JO. In: Diamond HS, editor. Medscape, vol. Lyme disease; 2022. https://emedicine.medscape.com/article/330178-overview. Accessed 26 Sept 2022.

    Google Scholar 

  3. Centers for Disease Control and Prevention. Lyme disease: data and surveillance. CDC. 2021. http://www.cdc.gov/lyme/stats/index.html?s_cid=cs_281. Accessed 30 Mar 2021.

  4. Wormser GP, Brisson D, Liveris D, et al. Borrelia burgdorferi genotype predicts the capacity for hematogenous dissemination during early Lyme disease. J Infect Dis. 2008;198(9):1358–64.

    Article  PubMed  Google Scholar 

  5. Wormser GP, Nowakowski J, Nadelman RB, Visintainer P, Levin A, Aguero-Rosenfeld ME. Impact of clinical variables on Borrelia burgdorferi-specific antibody seropositivity in acute-phase sera from patients in North America with culture-confirmed early Lyme disease. Clin Vaccine Immunol. 2008;15(10):1519–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Wormser GP, McKenna D, Carlin J, et al. Brief communication: hematogenous dissemination in early lyme disease. Ann Intern Med. 2005;142(9):751–5.

    Article  PubMed  Google Scholar 

  7. Bernardino AL, Myers TA, Alvarez X, Hasegawa A, Philipp MT. Toll-like receptors: insights into their possible role in the pathogenesis of Lyme neuroborreliosis. Infect Immun. 2008;76(10):4385–95.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Stanek G, Strle F. Lyme disease: European perspective. Infect Dis Clin N Am. 2008;22(2):327–39.

    Article  Google Scholar 

  9. Pritt BS, Mead PS, Johnson DKH, Neitzel DF, Respicio-Kingry LB, Davis JP, Schiffman E, Sloan LM, Schriefer ME, Replogle AJ, Paskewitz SM, Ray JA, Bjork J, Steward CR, Deedon A, Lee X, Kingry LC, Miller TK, Feist MA, Theel ES, Patel R, Irish CL, Petersen JM. Identification of a novel pathogenic Borrelia species causing Lyme borreliosis with unusually high spirochaetaemia: a descriptive study. Lancet Infect Dis. 2016;16(5):556–64. https://doi.org/10.1016/S1473-3099(15)00464-8. Epub 2016 Feb 6. Erratum in: lancet infect dis. 2016 Jun;16(6):636.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Masters EJ, Grigery CN, Masters RW. STARI, or Masters disease: lone star tick-vectored Lyme-like illness. Infect Dis Clin N Am. 2008;22(2):361–76.

    Article  Google Scholar 

  11. Varela AS, Luttrell MP, Howerth EW, et al. First culture isolation of Borrelia lonestari, putative agent of southern tick-associated rash illness. J Clin Microbiol. 2004;42(3):1163–9.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Nau R, Christen HJ, Eiffert H. Lyme disease–current state of knowledge. Dtsch Arztebl Int. 2009;106(5):72–81. quiz 82, I.

    PubMed  PubMed Central  Google Scholar 

  13. Steere AC, Angelis SM. Therapy for Lyme arthritis: strategies for the treatment of antibiotic-refractory arthritis. Arthritis Rheum. 2006;54(10):3079–86.

    Article  CAS  PubMed  Google Scholar 

  14. Kugeler KJ, Griffith KS, Gould LH, et al. A review of death certificates listing Lyme disease as a cause of death in the United States. Clin Infect Dis. 2011;52(3):364–7.

    Article  PubMed  Google Scholar 

  15. Seltzer EG, Gerber MA, Cartter ML, Freudigman K, Shapiro ED. Long-term outcomes of persons with Lyme disease. JAMA. 2000;283(5):609–16.

    Article  CAS  PubMed  Google Scholar 

  16. Shadick NA, Phillips CB, Sangha O, et al. Musculoskeletal and neurologic outcomes in patients with previously treated Lyme disease. Ann Intern Med. 1999;131(12):919–26.

    Article  CAS  PubMed  Google Scholar 

  17. Centers for Disease Control and Prevention. Lyme disease: diagnosis and testing. CDC. http://www.cdc.gov/lyme/diagnosistesting/LabTest/TwoStep/index.html. November 20, 2019; Accessed 30 Mar 2021.

  18. FDA. FDA clears new indications for existing Lyme disease tests that may help streamline diagnoses. U.S. Food & Drug Administration. https://www.fda.gov/news-events/press-announcements/fda-clears-new-indications-existing-lyme-disease-tests-may-help-streamline-diagnoses. July 29, 2019; Accessed 5 Apr 2021.

  19. Chau JK, Lin JR, Atashband S, Irvine RA, Westerberg BD. Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss. Laryngoscope. 2010;120:1011–21.

    Article  PubMed  Google Scholar 

  20. Lorenzi MC, Bittar RS, Pedalini ME, Zerati F, Yoshinari NH, Bento RF. Sudden deafness and Lyme disease. Laryngoscope. 2003;113:312–5.

    Article  PubMed  Google Scholar 

  21. Peltomaa M, Pyykkö I, Sappälä I, Viitanen L, Viljanen M. Lyme borreliosis, an etiological factor in sensorineural hearing loss? Eur Arch Otorhinolaryngol. 2000;257:317–22.

    Article  CAS  PubMed  Google Scholar 

  22. Goldfarb D, Sataloff RT. Lyme disease: a review for the otolaryngologist. Ear Nose Throat J. 1994;73:824–82.

    Article  CAS  PubMed  Google Scholar 

  23. Sowula K, Szaleniec J, Stolcman K, Ceranowicz P, Kocoń S, Tomik J. Association between sudden sensorineural hearing loss and Lyme disease. J Clin Med. 2021;10(5):1130.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Hydén D, Roberg M, Odkvist L. Borreliosis as a cause of sudden deafness and vestibular neuritis in Sweden. Acta Otolaryngol Suppl. 1995;520:320–2.

    Article  PubMed  Google Scholar 

  25. Amaro CE, Montalvão P, Huins C, Saraiva J. Lyme disease: sudden hearing loss as the sole presentation. J Laryngol Otol. 2015;129:183–6.

    Article  Google Scholar 

  26. Selmani Z, Pyykkö I. Cochlear and vestibular functional study in patients with sudden deafness a Lyme disease. Int J Otolaryngol Head Neck Surg. 2014;3:46–50.

    Article  Google Scholar 

  27. Ercolini AM, Miller SD. Role of immunologic cross-reactivity in neurological diseases. Neurol Res. 2005;27:726–33.

    Article  CAS  PubMed  Google Scholar 

  28. Peltomaa M, Pyykkö I, Seppälä I, et al. Lyme borreliosis, an etiological factor in sensorineural hearing loss ? Eur Arch Otorhinolaryngol. 2000;257:317–22.

    Article  CAS  PubMed  Google Scholar 

  29. Lorenzi MC, Bittar RS, Pedalini ME, et al. Sudden deafness and lyme disease. Laryngoscope. 2003;113:312–5.

    Article  PubMed  Google Scholar 

  30. Chau JK, Lin JR, Atashband S, et al. Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss. Laryngoscope. 2010;120:1011–21.

    Article  PubMed  Google Scholar 

  31. Bertholon P. Sensorineural hearing loss: a complex feature in lyme disease. Otol Neurotol. 2013;34(8):1543. https://doi.org/10.1097/MAO.0b013e3182a007d4.

    Article  PubMed  Google Scholar 

  32. Gagnebin J, Maire R. Infection screening in sudden and progressive idiopathic sensorineural hearing loss: a retrospective study of 182 cases. Otol Neurotol. 2002;23:160–2.

    Article  PubMed  Google Scholar 

  33. Talagrand-Reboul E, Raffetin A, Zachary P, Jaulhac B, Eldin C. Immunoserological diagnosis of human Borreliosis: current knowledge and perspectives. Front Cell Infect Microbiol. 2020;10:241.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Otorhinolaryngology, Şanlıurfa Training and Research Hospital, Şanlıurfa, Türkiye

    Mahmut Emre Gundogan

  2. Section of Otorhinolaryngology, Etimesgut Sait Ertürk State Hospital, Ankara, Türkiye

    Rezzan Okyay Budak

  3. Department of Otolaryngology Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Shigeru Hirano

Authors
  1. Mahmut Emre Gundogan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rezzan Okyay Budak
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shigeru Hirano
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mahmut Emre Gundogan .

Editor information

Editors and Affiliations

  1. Department of Pediatrics, University of Kocaeli, Medical Faculty, İzmit, Kocaeli, Türkiye

    Ayşe Engin Arısoy

  2. Department of Pediatrics, University of Kocaeli, Medical Faculty, İzmit, Kocaeli, Türkiye

    Emin Sami Arısoy

  3. Department of Otorhinolaryngology, Faculty of Medicine, Kırıkkale University, Kırıkkale, Türkiye

    Nuray Bayar Muluk

  4. Department of Otorhinolaryngology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Türkiye

    Cemal Cingi

  5. Division of Academic General Pediatrics, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA

    Armando G. Correa

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Gundogan, M.E., Okyay Budak, R., Hirano, S. (2023). Lyme Disease and Hearing Loss in Children. In: Arısoy, A.E., Arısoy, E.S., Bayar Muluk, N., Cingi, C., Correa, A.G. (eds) Hearing Loss in Congenital, Neonatal and Childhood Infections. Comprehensive ENT. Springer, Cham. https://doi.org/10.1007/978-3-031-38495-0_36

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-38495-0_36

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-38494-3

  • Online ISBN: 978-3-031-38495-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation