Skip to main content
SpringerLink
Log in

Non-invasive Ventilation for Stable Hypercapnic Chronic Obstructive Pulmonary Disease

  • Chapter
  • First Online:
Clinical Cases in Sleep Physical Therapy

  • 134 Accesses

Abstract

Long-term home non-invasive ventilation (NIV) is used widely in patients with chronic obstructive pulmonary disease, despite the evidence of benefits being mixed. However, recent large randomized trials have uniformly shown improvements in hospitalizations and mortality in selected patients with stable hypercapnia outside of a recent exacerbation of lung disease when a ventilation strategy targeting the maximal fall in carbon dioxide is used. However, achieving these higher inspiratory pressures may take time. This case study highlights issues around high-intensity NIV in this patient population, the role of sleep studies in titrating pressures, and the use of two-way remote monitoring to further optimize settings and identify potential issues impacting on adherence to therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Crimi C, Noto A, Princi P, Cuvelier A, Masa JF, Simonds A, et al. Domiciliary non-invasive ventilation in COPD: an International Survey of Indications and Practices. COPD. 2016;13(4):483–90.

    Article  PubMed  Google Scholar 

  2. Lloyd-Owen SJ, Donaldson GC, Ambrosino N, Escarabill J, Farre R, Fauroux B, et al. Patterns of home mechanical ventilation use in Europe: results from the Eurovent survey. Eur Respir J. 2005;25(6):1025–31.

    Article  CAS  PubMed  Google Scholar 

  3. Struik FM, Lacasse Y, Goldstein RS, Kerstjens HA, Wijkstra PJ. Nocturnal noninvasive positive pressure ventilation in stable COPD: a systematic review and individual patient data meta-analysis. Respir Med. 2014;108(2):329–37.

    Article  CAS  PubMed  Google Scholar 

  4. Osadnik CR, Tee VS, Carson-Chahhoud KV, Picot J, Wedzicha JA, Smith BJ. Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2017;7(7):CD004104.

    PubMed  Google Scholar 

  5. Casanova C, Celli BR, Tost L, Soriano E, Abreu J, Velasco V, et al. Long-term controlled trial of nocturnal nasal positive pressure ventilation in patients with severe COPD. Chest. 2000;118(6):1582–90.

    Article  CAS  PubMed  Google Scholar 

  6. Lin CC. Comparison between nocturnal nasal positive pressure ventilation combined with oxygen therapy and oxygen monotherapy in patients with severe COPD. Am J Respir Crit Care Med. 1996;154(2 Pt 1):353–8.

    Article  CAS  PubMed  Google Scholar 

  7. McEvoy RD, Pierce RJ, Hillman D, Esterman A, Ellis EE, Catcheside PG, et al. Nocturnal non-invasive nasal ventilation in stable hypercapnic COPD: a randomised controlled trial. Thorax. 2009;64(7):561–6.

    Article  CAS  PubMed  Google Scholar 

  8. Kohnlein T, Windisch W, Kohler D, Drabik A, Geiseler J, Hartl S, et al. Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial. Lancet Respir Med. 2014;2(9):698–705.

    Article  PubMed  Google Scholar 

  9. Murphy PB, Rehal S, Arbane G, Bourke S, Calverley PMA, Crook AM, et al. Effect of home noninvasive ventilation with oxygen therapy vs oxygen therapy alone on hospital readmission or death after an acute COPD exacerbation: a randomized clinical trial. JAMA. 2017;317(21):2177–86.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Struik FM, Sprooten RT, Kerstjens HA, Bladder G, Zijnen M, Asin J, et al. Nocturnal non-invasive ventilation in COPD patients with prolonged hypercapnia after ventilatory support for acute respiratory failure: a randomised, controlled, parallel-group study. Thorax. 2014;69(9):826–34.

    Article  CAS  PubMed  Google Scholar 

  11. Windisch W, Haenel M, Storre JH, Dreher M. High-intensity non-invasive positive pressure ventilation for stable hypercapnic COPD. Int J Med Sci. 2009;6(2):72–6.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Ergan B, Oczkowski S, Rochwerg B, Carlucci A, Chatwin M, Clini E, et al. European Respiratory Society guidelines on long-term home non-invasive ventilation for management of COPD. Eur Respir J. 2019;54(3):1901003.

    Article  PubMed  Google Scholar 

  13. Macrea M, Oczkowski S, Rochwerg B, Branson RD, Celli B, Coleman JM, et al. Long-term noninvasive ventilation in chronic stable hypercapnic chronic obstructive pulmonary disease. An official American Thoracic Society clinical practice guideline. Am J Respir Crit Care Med. 2020;202(4):e74–87.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Raveling T, Vonk J, Struik FM, Goldstein R, Kerstjens HA, Wijkstra PJ, et al. Chronic non-invasive ventilation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2021;8(8):CD002878.

    PubMed  Google Scholar 

  15. Dreher M, Ekkernkamp E, Walterspacher S, Walker D, Schmoor C, Storre JH, et al. Noninvasive ventilation in COPD: impact of inspiratory pressure levels on sleep quality. Chest. 2011;140(4):939–45.

    Article  PubMed  Google Scholar 

  16. Duiverman ML, Maagh P, Magnet FS, Schmoor C, Arellano-Maric MP, Meissner A, et al. Impact of high-intensity-NIV on the heart in stable COPD: a randomised cross-over pilot study. Respir Res. 2017;18(1):76.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Nilius G, Katamadze N, Domanski U, Schroeder M, Franke KJ. Non-invasive ventilation with intelligent volume-assured pressure support versus pressure-controlled ventilation: effects on the respiratory event rate and sleep quality in COPD with chronic hypercapnia. Int J Chron Obstruct Pulmon Dis. 2017;12:1039–45.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Oscroft NS, Ali M, Gulati A, Davies MG, Quinnell TG, Shneerson JM, et al. A randomised crossover trial comparing volume assured and pressure preset noninvasive ventilation in stable hypercapnic COPD. COPD. 2010;7(6):398–403.

    Article  PubMed  Google Scholar 

  19. Storre JH, Matrosovich E, Ekkernkamp E, Walker DJ, Schmoor C, Dreher M, et al. Home mechanical ventilation for COPD: high-intensity versus target volume noninvasive ventilation. Respir Care. 2014;59(9):1389–97.

    Article  PubMed  Google Scholar 

  20. Kelly JL, Jaye J, Pickersgill RE, Chatwin M, Morrell MJ, Simonds AK. Randomized trial of ‘intelligent’ autotitrating ventilation versus standard pressure support non-invasive ventilation: impact on adherence and physiological outcomes. Respirology. 2014;19(4):596–603.

    Article  PubMed  Google Scholar 

  21. Piper AJ. Advances in non-invasive positive airway pressure technology. Respirology. 2020;25(4):372–82.

    Article  PubMed  Google Scholar 

  22. Elliott MW. The interface: crucial for successful noninvasive ventilation. Eur Respir J. 2004;23(1):7–8.

    Article  CAS  PubMed  Google Scholar 

  23. Callegari J, Magnet FS, Taubner S, Berger M, Schwarz SB, Windisch W, et al. Interfaces and ventilator settings for long-term noninvasive ventilation in COPD patients. Int J Chron Obstruct Pulmon Dis. 2017;12:1883–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Lebret M, Leotard A, Pepin JL, Windisch W, Ekkernkamp E, Pallero M, et al. Nasal versus oronasal masks for home non-invasive ventilation in patients with chronic hypercapnia: a systematic review and individual participant data meta-analysis. Thorax. 2021;76(11):1108–16.

    Article  PubMed  Google Scholar 

  25. Ribeiro C, Vieira AL, Pamplona P, Drummond M, Seabra B, Ferreira D, et al. Current practices in home mechanical ventilation for chronic obstructive pulmonary disease: a real-life cross-sectional multicentric study. Int J Chron Obstruct Pulmon Dis. 2021;16:2217–26.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Majorski DS, Callegari JC, Schwarz SB, Magnet FS, Majorski R, Storre JH, et al. Oronasal versus nasal masks for non-invasive ventilation in COPD: a randomized crossover trial. Int J Chron Obstruct Pulmon Dis. 2021;16:771–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Duiverman ML, Vonk JM, Bladder G, van Melle JP, Nieuwenhuis J, Hazenberg A, et al. Home initiation of chronic non-invasive ventilation in COPD patients with chronic hypercapnic respiratory failure: a randomised controlled trial. Thorax. 2020;75(3):244–52.

    Article  PubMed  Google Scholar 

  28. Sheers N, Berlowitz DJ, Rautela L, Batchelder I, Hopkinson K, Howard ME. Improved survival with an ambulatory model of non-invasive ventilation implementation in motor neuron disease. Amyotroph Lateral Scler Frontotemporal Degener. 2014;15(3-4):180–4.

    Article  PubMed  Google Scholar 

  29. Frazier WD, DaVanzo JE, Dobson A, Heath S, Mati K. Early initiation of non-invasive ventilation at home improves survival and reduces healthcare costs in COPD patients with chronic hypercapnic respiratory failure: a retrospective cohort study. Respir Med. 2022;200:106920.

    Article  PubMed  Google Scholar 

  30. Hazenberg A, Kerstjens HA, Prins SC, Vermeulen KM, Wijkstra PJ. Initiation of home mechanical ventilation at home: a randomised controlled trial of efficacy, feasibility and costs. Respir Med. 2014;108(9):1387–95.

    Article  CAS  PubMed  Google Scholar 

  31. Lujan M, Moreno A, Veigas C, Monton C, Pomares X, Domingo C. Non-invasive home mechanical ventilation: effectiveness and efficiency of an outpatient initiation protocol compared with the standard in-hospital model. Respir Med. 2007;101(6):1177–82.

    Article  PubMed  Google Scholar 

  32. Hannan LM, Rautela L, Berlowitz DJ, McDonald CF, Cori JM, Sheers N, et al. Randomised controlled trial of polysomnographic titration of noninvasive ventilation. Eur Respir J. 2019;53(5):1802118.

    Article  CAS  PubMed  Google Scholar 

  33. Adler D, Perrig S, Takahashi H, Espa F, Rodenstein D, Pepin JL, et al. Polysomnography in stable COPD under non-invasive ventilation to reduce patient-ventilator asynchrony and morning breathlessness. Sleep Breath. 2012;16(4):1081–90.

    Article  PubMed  Google Scholar 

  34. McDowell G, Sumowski M, Toellner H, Karok S, O’Dwyer C, Hornsby J, et al. Assistive technologies for home NIV in patients with COPD: feasibility and positive experience with remote-monitoring and volume-assured auto-EPAP NIV mode. BMJ Open Respir Res. 2021;8(1):e000828.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Contal O, Vignaux L, Combescure C, Pepin JL, Jolliet P, Janssens JP. Monitoring of noninvasive ventilation by built-in software of home bilevel ventilators: a bench study. Chest. 2012;141(2):469–76.

    Article  PubMed  Google Scholar 

  36. Stagnara A, Baboi L, Nesme P, Subtil F, Louis B, Guerin C. Reliability of tidal volume in average volume assured pressure support mode. Respir Care. 2018;63(9):1139–46.

    Article  PubMed  Google Scholar 

  37. Borel JC, Pelletier J, Taleux N, Briault A, Arnol N, Pison C, et al. Parameters recorded by software of non-invasive ventilators predict COPD exacerbation: a proof-of-concept study. Thorax. 2015;70(3):284–5.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Respiratory Support Service, Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia

    Amanda J. Piper

Authors
  1. Amanda J. Piper
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Neurology and Neurosurgery Department, Federal University of São Paulo (UNIFESP), São Paulo, São Paulo, Brazil

    Cristina Frange

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Piper, A.J. (2023). Non-invasive Ventilation for Stable Hypercapnic Chronic Obstructive Pulmonary Disease. In: Frange, C. (eds) Clinical Cases in Sleep Physical Therapy. Springer, Cham. https://doi.org/10.1007/978-3-031-38340-3_28

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-38340-3_28

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-38339-7

  • Online ISBN: 978-3-031-38340-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation