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Callosal Abnormalities in Schizophrenia

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The Corpus Callosum

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Abstract

Schizophrenia affects 1% of people during their lifetimes. It is characterized by difficulties in social functioning, self-care skills, and reality discrimination and causes abnormalities in perception, emotion, cognition, thought, and behavior. The multifactorial neurodevelopmental model best explains its etiology. In some investigations of the etiology of schizophrenia, decreases in size, fiber density, and fractional anisotropy of the corpus callosum (CC) and some of its subregions have been demonstrated. In this chapter, differences in the CC and its subregions in schizophrenia patients, gender-related differences, the effects of treatments on the CC, and the value of callosotomy in treating schizophrenia will be examined in light of the literature.

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References

  1. Tandon R, Gaebel W, Barch DM, Bustillo J, Gur RE, Heckers S, et al. Definition and description of schizophrenia in the DSM-5. Schizophr Res. 2013;150(1):3–10.

    Article  PubMed  Google Scholar 

  2. Hany M, Rehman B, Azhar Y, Chapman J. Continuing education activity. 2021.

    Google Scholar 

  3. Kuniyoshi JS, McClellan JM. Early-onset schizophrenia. Washington, DC: American Psychiatric Publishing; 2010.

    Google Scholar 

  4. Highley JR, Esiri MM, McDonald B, Cortina-Borja M, Herron BM, Crow TJ. The size and fibre composition of the corpus callosum with respect to gender and schizophrenia: a post-mortem study. Brain. 1999;122(1):99–110.

    Article  PubMed  Google Scholar 

  5. Hoff AL, Neal C, Kushner M, DeLisi LE. Gender differences in corpus callosum size in first-episode schizophrenics. Biol Psychiatry. 1994;35(12):913–9.

    Article  CAS  PubMed  Google Scholar 

  6. Apak S. “Korpus Kallozum” Beynin Merkezindeki Gizemli Bölge-Derleme. 2009.

    Google Scholar 

  7. Raybaud C. The corpus callosum, the other great forebrain commissures, and the septum pellucidum: anatomy, development, and malformation. Neuroradiology. 2010;52(6):447–77.

    Article  PubMed  Google Scholar 

  8. Kier EL, Truwit CL. The lamina rostralis: modification of concepts concerning the anatomy, embryology, and MR appearance of the rostrum of the corpus callosum. Am J Neuroradiol. 1997;18(4):715–22.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Hofer S, Frahm J. Topography of the human corpus callosum revisited—comprehensive fiber tractography using diffusion tensor magnetic resonance imaging. NeuroImage. 2006;32(3):989–94.

    Article  PubMed  Google Scholar 

  10. Velut S, Destrieux C, Kakou M. Anatomie morphologique du corps calleux. Neurochir Suppl. 1998;44(1):17–30.

    CAS  Google Scholar 

  11. Aboitiz F, Montiel J. One hundred million years of interhemispheric communication: the history of the corpus callosum. Braz J Med Biol Res. 2003;36:409–20.

    Article  CAS  PubMed  Google Scholar 

  12. Banich MT. The missing link: the role of interhemispheric interaction in attentional processing. Brain Cogn. 1998;36(2):128–57.

    Article  CAS  PubMed  Google Scholar 

  13. Giedd JN, Rumsey JM, Castellanos FX, Rajapakse JC, Kaysen D, Vaituzis AC, et al. A quantitative MRI study of the corpus callosum in children and adolescents. Dev Brain Res. 1996;91(2):274–80.

    Article  CAS  Google Scholar 

  14. Brown WS, Paul LK, Symington M, Dietrich R. Comprehension of humor in primary agenesis of the corpus callosum. Neuropsychologia. 2005;43(6):906–16.

    Article  PubMed  Google Scholar 

  15. Voineskos AN, Rajji TK, Lobaugh NJ, Miranda D, Shenton ME, Kennedy JL, et al. Age-related decline in white matter tract integrity and cognitive performance: a DTI tractography and structural equation modeling study. Neurobiol Aging. 2012;33(1):21–34.

    Article  PubMed  Google Scholar 

  16. Luders E, Thompson PM, Narr KL, Zamanyan A, Chou Y-Y, Gutman B, et al. The link between callosal thickness and intelligence in healthy children and adolescents. NeuroImage. 2011;54(3):1823–30.

    Article  PubMed  Google Scholar 

  17. Penke L, Maniega SM, Murray C, Gow AJ, Hernández MCV, Clayden JD, et al. A general factor of brain white matter integrity predicts information processing speed in healthy older people. J Neurosci. 2010;30(22):7569–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. van Eimeren L, Niogi SN, McCandliss BD, Holloway ID, Ansari D. White matter microstructures underlying mathematical abilities in children. Neuroreport. 2008;19(11):1117–21.

    Article  PubMed  Google Scholar 

  19. de Sonneville L, Njiokiktjien C. Pediatric behavioural neurology. Amsterdam: Suyi Publications; 1988.

    Google Scholar 

  20. Bloom JS, Hynd GW. The role of the corpus callosum in interhemispheric transfer of information: excitation or inhibition? Neuropsychol Rev. 2005;15(2):59–71.

    Article  PubMed  Google Scholar 

  21. Henze R, Brunner R, Thiemann U, Parzer P, Klein J, Resch F, et al. White matter alterations in the corpus callosum of adolescents with first-admission schizophrenia. Neurosci Lett. 2012;513(2):178–82.

    Article  CAS  PubMed  Google Scholar 

  22. Lui S, Yao L, Xiao Y, Keedy S, Reilly J, Keefe R, et al. Resting-state brain function in schizophrenia and psychotic bipolar probands and their first-degree relatives. Psychol Med. 2015;45(1):97–108.

    Article  CAS  PubMed  Google Scholar 

  23. Zhang W, Lei D, Keedy SK, Ivleva EI, Eum S, Yao L, et al. Brain gray matter network organization in psychotic disorders. Neuropsychopharmacology. 2020;45(4):666–74.

    Article  PubMed  Google Scholar 

  24. Francis AN, Mothi SS, Mathew IT, Tandon N, Clementz B, Pearlson GD, et al. Callosal abnormalities across the psychosis dimension: bipolar schizophrenia network on intermediate phenotypes. Biol Psychiatry. 2016;80(8):627–35.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Walterfang M, Velakoulis D. Callosal morphology in schizophrenia: what can shape tell us about function and illness? Br J Psychiatry. 2014;204(1):9–11.

    Article  PubMed  Google Scholar 

  26. Collinson SL, Gan SC, San Woon P, Kuswanto C, Sum MY, Yang GL, et al. Corpus callosum morphology in first-episode and chronic schizophrenia: combined magnetic resonance and diffusion tensor imaging study of Chinese Singaporean patients. Br J Psychiatry. 2014;204(1):55–60.

    Article  PubMed  Google Scholar 

  27. Bachmann S, Pantel J, Flender A, Bottmer C, Essig M, Schröder J. Corpus callosum in first-episode patients with schizophrenia–a magnetic resonance imaging study. Psychol Med. 2003;33(6):1019–27.

    Article  CAS  PubMed  Google Scholar 

  28. Keshavan M, Diwadkar V, Harenski K, Rosenberg D, Sweeney J, Pettegrew JW. Abnormalities of the corpus callosum in first episode, treatment naive schizophrenia. J Neurol Neurosurg Psychiatry. 2002;72(6):757–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Walterfang M, Wood AG, Reutens DC, Wood SJ, Chen J, Velakoulis D, et al. Morphology of the corpus callosum at different stages of schizophrenia: crosssectional study in first-episode and chronic illness. Br J Psychiatry. 2008;192:429–34. https://doi.org/10.1192/bjp.bp.107.041251.

    Article  PubMed  Google Scholar 

  30. Takahashi M, Matsui M, Nakashima M, Takahashi T, Suzuki M. Callosal size in first-episode schizophrenia patients with illness duration of less than one year: a cross-sectional MRI study. Asian J Psychiatr. 2017;25:197–202. https://doi.org/10.1016/j.ajp.2016.10.031.

    Article  PubMed  Google Scholar 

  31. Mitelman SA, Nikiforova YK, Canfield EL, Hazlett EA, Brickman AM, Shihabuddin L, et al. A longitudinal study of the corpus callosum in chronic schizophrenia. Schizophr Res. 2009;114(1–3):144–53.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Del Re EC, Bouix S, Fitzsimmons J, Blokland GA, Mesholam-Gately R, Wojcik J, et al. Diffusion abnormalities in the corpus callosum in first episode schizophrenia: associated with enlarged lateral ventricles and symptomatology. Psychiatry Res. 2019;277:45–51.

    Article  PubMed  PubMed Central  Google Scholar 

  33. de Moura MT, Zanetti MV, Duran FL, Schaufelberger MS, Menezes PR, Scazufca M, et al. Corpus callosum volumes in the 5 years following the first-episode of schizophrenia: effects of antipsychotics, chronicity and maturation. Neuroimage Clin. 2018;18:932–42.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Tao B, Xiao Y, Cao H, Zhang W, Yang C, Lencer R, et al. Characteristics of the corpus callosum in chronic schizophrenia treated with clozapine or risperidone and those never-treated. BMC Psychiatry. 2021;21(1):1–10.

    Article  Google Scholar 

  35. Howes OD, McCutcheon R, Agid O, De Bartolomeis A, Van Beveren NJ, Birnbaum ML, et al. Treatment-resistant schizophrenia: treatment response and resistance in psychosis (TRRIP) working group consensus guidelines on diagnosis and terminology. Am J Psychiatr. 2017;174(3):216–29.

    Article  PubMed  Google Scholar 

  36. Holleran L, Ahmed M, Anderson-Schmidt H, McFarland J, Emsell L, Leemans A, et al. Altered interhemispheric and temporal lobe white matter microstructural organization in severe chronic schizophrenia. Neuropsychopharmacology. 2014;39(4):944–54.

    Article  PubMed  Google Scholar 

  37. Assunção-Leme IB, Zugman A, De Moura LM, Sato JR, Higuchi C, Ortiz BB, et al. Is treatment-resistant schizophrenia associated with distinct neurobiological callosal connectivity abnormalities? CNS Spectr. 2021;26(5):545–9.

    Article  PubMed  Google Scholar 

  38. Abel KM, Drake R, Goldstein JM. Sex differences in schizophrenia. Int Rev Psychiatry. 2010;22:417–28.

    Article  PubMed  Google Scholar 

  39. Liu F, Vidarsson L, Winter JD, Tran H, Kassner A. Sex differences in the human corpus callosum microstructure: a combined T2 myelin-water and diffusion tensor magnetic resonance imaging study. Brain Res. 2010;1343:37–45.

    Article  CAS  PubMed  Google Scholar 

  40. Westerhausen R, Kreuder F, Sequeira SDS, Walter C, Woerner W, Wittling RA, et al. Effects of handedness and gender on macro-and microstructure of the corpus callosum and its subregions: a combined high-resolution and diffusion-tensor MRI study. Cogn Brain Res. 2004;21(3):418–26.

    Article  Google Scholar 

  41. Witelson SF. Hand and sex differences in the isthmus and genu of the human corpus callosum: a postmortem morphological study. Brain. 1989;112(3):799–835.

    Article  PubMed  Google Scholar 

  42. Shahab S, Stefanik L, Foussias G, Lai M-C, Anderson KK, Voineskos AN. Sex and diffusion tensor imaging of white matter in schizophrenia: a systematic review plus meta-analysis of the corpus callosum. Schizophr Bull. 2018;44(1):203–21.

    Article  PubMed  Google Scholar 

  43. Jaynes J. The origin of consciousness in the breakdown of the bicameral mind. Boston, MA: Houghton Mifflin Harcourt; 2000.

    Google Scholar 

  44. Neumaier F, Paterno M, Alpdogan S, Tevoufouet EE, Schneider T, Hescheler J, et al. In reply to corpus Callosotomy for drug-resistant schizophrenia; novel treatment based on pathophysiology. World Neurosurg. 2018;116:485–6.

    Article  PubMed  Google Scholar 

  45. Taghipour M, Ghaffarpasand F. Corpus callosotomy for drug-resistant schizophrenia; novel treatment based on pathophysiology. World Neurosurg. 2018;116:483–4.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Kocaeli City Hospital, İzmit, Turkey

    Damla Balkan Erdoğan

  2. Department of Child and Adolescent Psychiatry, Muğla Sıtkı Koçman University School of Medicine, Muğla, Turkey

    Nilfer Şahin

  3. Department of Psychiatry, Muğla Sıtkı Koçman University School of Medicine, Muğla, Turkey

    Öykü Özçelik & Osman Vırıt

Authors
  1. Damla Balkan Erdoğan
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  2. Nilfer Şahin
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  3. Öykü Özçelik
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  4. Osman Vırıt
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Editor information

Editors and Affiliations

  1. Faculty of Medicine, Department of Neurosurgery, Aydın Adnan Menderes University, Aydın, Türkiye

    Mehmet Turgut

  2. Department of Neurosurgery, Tulane School of Medicine, New Orleans, LA, USA

    R. Shane Tubbs

  3. Faculty of Medicine, Department of Radiology, Ankara Medipol University, Ankara, Türkiye

    Ahmet Tuncay Turgut

  4. Department of Neurosurgery, Ochsner Medical Center, New Orleans, LA, USA

    Cuong C.J. Bui

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Erdoğan, D.B., Şahin, N., Özçelik, Ö., Vırıt, O. (2023). Callosal Abnormalities in Schizophrenia. In: Turgut, M., Tubbs, R.S., Turgut, A.T., Bui, C.C. (eds) The Corpus Callosum. Springer, Cham. https://doi.org/10.1007/978-3-031-38114-0_31

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  • DOI: https://doi.org/10.1007/978-3-031-38114-0_31

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-38113-3

  • Online ISBN: 978-3-031-38114-0

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