Abstract
Skin cancer is a serious public health problem with a sharply increasing incidence in recent years, which has a major impact on quality of life and can be disfiguring or even fatal. Deep learning techniques can be used to analyze dermoscopic images, resulting in automated systems that can improve the clinical confidence of the diagnosis – also avoiding unnecessary surgery – help clinicians objectively communicate its outcome, reduce errors related to human fatigue, and cut costs affecting the health system. In this chapter, we present an entire pipeline to analyze skin lesion images in order to distinguish nevi from melanomas, also integrating patient clinical data to reach a diagnosis. Furthermore, to make our artificial intelligence tool explainable for both clinicians and patients, dermoscopic images are further processed to obtain their segmented counterparts, where the lesion contour is easily observable, and saliency maps, highlighting the areas of the lesion that prompted the classifier to make its decision. Experimental results are promising and have been positively evaluated by human experts.
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Notes
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Publicy available at https://simonebonechi.github.io/downloads/isic_wsm.
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In May 2018, a uniform data law was approved for all 27 EU member states, aimed at protecting the privacy of European citizens on digital infrastructures around the world, called General Data Protection Regulation.
References
Alber, M., Lapuschkin, S., Seegerer, P., Hägele, M., Schütt, K.T., Montavon, G., Samek, W., Müller, K.R., Dähne, S., Kindermans, P.J.: iNNvestigate neural networks! J. Mach. Learn. Res. 20(93), 1–8 (2019)
Andreini, P., Bonechi, S., Bianchini, M., Mecocci, A., Di Massa, V.: Automatic image classification for the urinoculture screening. In: Intelligent Decision Technologies: proceedings of the 7th KES International Conference on Intelligent Decision Technologies (KES-IDT 2015), pp. 31–42. Springer (2015)
Andreini, P., Ciano, G., Bonechi, S., Graziani, C., Lachi, V., Mecocci, A., Sodi, A., Scarselli, F., Bianchini, M.: A two-stage GAN for high-resolution retinal image generation and segmentation. Electronics 11(1), 60 (2021)
Bonechi, S.: A weakly supervised approach to skin lesion segmentation. In: ESANN 2022 Proceedings European Symposium on Artificial Neural Networks, Computational Intelligence and Machine Learning (2022)
Bonechi, S.: ISIC_WSM: generating weak segmentation maps for the ISIC archive. Neurocomputing 523, 69–80 (2023)
Bonechi, S., Andreini, P., Bianchini, M., Scarselli, F.: Generating bounding box supervision for semantic segmentation with deep learning. In: IAPR Workshop on Artificial Neural Networks in Pattern Recognition, pp. 190–200. Springer (2018)
Bonechi, S., Andreini, P., Mecocci, A., Giannelli, N., Scarselli, F., Neri, E., Bianchini, M., Dimitri, G.M.: Segmentation of aorta 3D CT images based on 2D convolutional neural networks. Electronics 10(20), 2559 (2021)
Bonechi, S., Bianchini, M., Bongini, P., Ciano, G., Giacomini, G., Rosai, R., Tognetti, L., Rossi, A., Andreini, P.: Fusion of visual and anamnestic data for the classification of skin lesions with deep learning. In: International Conference on Image Analysis and Processing, pp. 211–219. Springer (2019)
Bonechi, S., Bianchini, M., Mecocci, A., Scarselli, F., Andreini, P.: Segmentation of Petri plate images for automatic reporting of urine culture tests. In: Handbook of Artificial Intelligence in Healthcare, pp. 127–151. Springer (2022)
Bonechi, S., Bianchini, M., Scarselli, F., Andreini, P.: Weak supervision for generating pixel-level annotations in scene text segmentation. Pattern Recogn. Lett. 138, 1–7 (2020)
Chen, L.C., Papandreou, G., Kokkinos, I., Murphy, K., Yuille, A.L.: DeepLab: semantic image segmentation with deep convolutional nets, atrous convolution, and fully connected CRFs. IEEE Trans. Pattern Anal Mach Intell 40(4), 834–848 (2017)
Chéron, G., Laptev, I., Schmid, C.: P-CNN: pose—Based CNN features for action recognition. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 3218–3226 (2015)
Codella, N., Rotemberg, V., Tschandl, P., Celebi, M.E., Dusza, S., Gutman, D., Helba, B., Kalloo, A., Liopyris, K., Marchetti, M., et al.: Skin lesion analysis toward melanoma detection 2018: a challenge hosted by the International Skin Imaging Collaboration (ISIC) (2019). arXiv:1902.03368
Domingues, B., Lopes, J.M., Soares, P., Pópulo, H.: Melanoma treatment in review. ImmunoTargets. Therapy 7, 35–49 (2018)
Esteva, A., Kuprel, B., Novoa, R.A., Ko, J., Swetter, S.M., Blau, H.M., Thrun, S.: Dermatologist-level classification of skin cancer with deep neural networks. Nature 542(7639), 115–118 (2017)
Goodfellow, I., Bengio, Y., Courville, A.: Deep Learning. MIT Press Ltd. (2016)
Grote, T., Keeling, G.: Enabling fairness in healthcare through machine learning. Ethics Inf. Technol. 24(39) (2022)
Guo, M.H., Lu, C.Z., Hou, Q., Liu, Z., Cheng, M.M., Hu, S.M.: SegNeXt: rethinking convolutional attention design for semantic segmentation (2022). arXiv:2209.08575
Hasan, M.K., Elahi, M.T.E., Alam, M.A., Jawad, M.T., Martí, R.: DermoExpert: skin lesion classification using a hybrid convolutional neural network through segmentation, transfer learning, and augmentation. Inform. Med. Unlock. 100819 (2022)
He, K., Gkioxari, G., Dollár, P., Girshick, R.: Mask R-CNN. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 2961–2969 (2017)
He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 770–778 (2016)
ISIC: SIIM–ISIC 2020 challenge dataset (2020). https://challenge2020.isic-archive.com/
Kaissis, G.A., Makowski, M.R., Rückert, D., Braren, R.F.: Secure, privacy-preserving and federated machine learning in medical imaging. Nat. Mach. Intell. 2, 305–311 (2020)
Krizhevsky, A., Sutskever, I., Hinton, G.E.: ImageNet classification with deep convolutional neural networks. Adv. Neural Inf. Process. Syst. 25, 1097–1105 (2012)
Litjens, G., Kooi, T., Bejnordi, B.E., Setio, A.A.A., Ciompi, F., Ghafoorian, M., Van Der Laak, J.A., Van Ginneken, B., Sánchez, C.I.: A survey on deep learning in medical image analysis. Med. Image Anal. 42, 60–88 (2017)
Long, J., Shelhamer, E., Darrell, T.: Fully convolutional networks for semantic segmentation. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 3431–3440 (2015)
Nie, Y., Sommella, P., Carratù, M., Ferro, M., O’Nils, M., Lundgren, J.: Recent advances in diagnosis of skin lesions using dermoscopic images based on deep learning. IEEE Access 10, 95716–95747 (2022)
Oneto, L., Navarin, N., Biggio, B., Errica, F., Micheli, A., Scarselli, F., Bianchini, M., Demetrio, L., Bongini, P., Tacchella, A., Sperduti, A.: Towards learning trustworthily, automatically, and with guarantees on graphs: an overview. Neurocomputing 493, 217–243 (2022)
Papandreou, G., Kokkinos, I., Savalle, P.A.: Untangling local and global deformations in deep convolutional networks for image classification and sliding window detection (2014). arXiv:1412.0296
Redmon, J., Farhadi, A.: YOLOv3: an incremental improvement (2018). arXiv:1804.02767
Rodriguez, D., Nayak, T., Chen, Y., Krishnan, R., Huang, Y.: On the role of deep learning model complexity in adversarial robustness for medical images. BMC Med. Inform. Decis. Making 22(Suppl 2)(160) (2022)
Rossi, A., Vannuccini, G., Andreini, P., Bonechi, S., Giacomini, G., Scarselli, F., Bianchini, M.: Analysis of brain NMR images for age estimation with deep learning. Procedia Comput. Sci. 159, 981–989 (2019)
Selvaraju, R.R., Cogswell, M., Das, A., Vedantam, R., Parikh, D., Batra, D.: Grad—CAM: Visual explanations from deep networks via gradient—Based localization. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 618–626 (2017)
Springenberg, J.T., Dosovitskiy, A., Brox, T., Riedmiller, M.: Striving for simplicity: the all convolutional net (2014). arXiv:1412.6806
Thapar, P., Rakhra, M., Cazzato, G., Hossain, M.S.: A novel hybrid deep learning approach for skin lesion segmentation and classification. J. Healthc. Eng. 2022 (2022)
Tognetti, L., Bonechi, S., Andreini, P., Bianchini, M., Scarselli, F., Cevenini, G., Moscarella, E., Farnetani, F., Longo, C., Lallas, A., et al.: A new deep learning approach integrated with clinical data for the dermoscopic differentiation of early melanomas from atypical nevi. J. Dermatol. Sci. 101(2), 115–122 (2021)
Tschandl, P., Rosendahl, C., Kittler, H.: The HAM10000 dataset, a large collection of multi-source dermatoscopic images of common pigmented skin lesions. Sci. Data 5(1), 1–9 (2018)
Zhao, H., Shi, J., Qi, X., Wang, X., Jia, J.: Pyramid scene parsing network. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2881–2890 (2017)
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Bianchini, M., Andreini, P., Bonechi, S. (2023). From Pixels to Diagnosis: AI-Driven Skin Lesion Recognition. In: Kwaśnicka, H., Jain, N., Markowska-Kaczmar, U., Lim, C.P., Jain, L.C. (eds) Advances in Smart Healthcare Paradigms and Applications. Intelligent Systems Reference Library, vol 244. Springer, Cham. https://doi.org/10.1007/978-3-031-37306-0_6
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