Abstract
Even since antiquity, and thanks to their ingenuity, doctors have benefited from using natural materials “biomaterials” to substitute tissue, organs or other body parts. Over time, traditional and rudimentary biomaterials have been replaced with improved and targeted synthetic materials specially designed for specific applications. This chapter provides an overview of natural and synthetic biomaterials, used in developing innovative devices for tissue engineering applications, from polymers and ceramics to composite materials (metals were discussed in more details in Chap. 1). The first part of this chapter presents a comprehensive overview of the first biomaterials used in ancient medicine. This part highlights the essential role that primitive biomaterials brought in today’s medicine. In the second part, natural and synthetic biomaterials are very thoroughly presented. The main aspect of these biomaterials is related to their physicochemical and mechanical properties, which must be considered when featured for tissue engineering applications. The focus of the third part will significantly illustrate the interconnection and combination between medicine and scientific research to develop new platforms for tissue engineering applications. Over the past few decades, researchers and scientists have demonstrated considerable progress in developing novel biomaterials as substitutes for replacing and repairing diverse damaged tissues. Lastly, conclusions and future trends review the most important and complex aspects that tissue engineering provides in combing diverse materials to develop suitable substitutes to alleviate patients’ lives.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Huebsch N, Mooney DJ (2009) Inspiration and application in the evolution of biomaterials. Nature 462(7272):426–432
Ratner BD, Bryant SJ (2004) Biomaterials: where we have been and where we are going. Annu Rev Biomed Eng 6:41–75
Tathe A, Ghodke M, Nikalje AP (2010) A brief review biomaterials and their application. Int J Pharm Pharm Sci 2(4):19–23
Helmus MN, Gibbons DF, Cebon D (2008) Biocompatibility: meeting a key functional requirement of next-generation medical devices. Toxicol Pathol 36:70–80
Patel NR, Gohil PP (2012) A review on biomaterials: Scope, applications and human anatomy significance. Int J Emerg Technol Adv Eng 2(4):91–101
Ratner BD, Hoffman AS, Schoen FJ, Lemons JE (2020) Biomaterials science: an introduction to materials in medicine. Elsevier Academic Press, London
Namvar F, Jawaid M, Md Tahir P, Mohamad R, Azizi S, Khodavandi A, Rahman HS, Nayeri MD (2014) Potential use of plant fibres and their composites for biomedical applications. BioResources 9(3):5688–5706
Ramakrishna S, Mayer J, Wintermantel E, Leong KW (2001) Biomedical applications of polymer-composite materials: a review. Compos Sci Technol 61:1189–1224
Kutz M (2003) Standard handbook of biomedical engineering and design. In McGraw-Hill (ed)
Parida P, Behera A, Mishra SC (2012) Classification of biomaterials used in medicine. Int J Adv Appl Sci 1(3):125–129
Chen C, Xi Y, Weng Y (2022) Progress in the development of graphene-based biomaterials for tissue engineering and regeneration. Mater (Basel) 15(6)
Chong ETJ, Ng JW, Lee P-C (2022) Classification and medical applications of biomaterials—a mini review. BIO integration
Eldeeb AE, Salah S, Elkasabgy NA (2022) Biomaterials for tissue engineering applications and current updates in the field: a comprehensive review. AAPS PharmSciTech 23(7):267
Rubežić MZ, Krstić AB, Stanković HZ, Ljupković RB, Ranđelović MS, Zarubica AR (2020) Different types of biomaterials—structure and applications—a short review. Adv Technol 9(1):69–79
Anil S, Chalisserry EP, Nam SY, Venkatesan J (2019) Biomaterials for craniofacial tissue engineering and regenerative dentistry. In: Advanced dental biomaterials, pp 643–674
Ferreira AM, Gentile P, Chiono V, Ciardelli G (2012) Collagen for bone tissue regeneration. Acta Biomater 8(9):3191–3200
Abou Neel EA, Salih V, Revell PA, Young AM (2012) Viscoelastic and biological performance of low-modulus, reactive calcium phosphate-filled, degradable, polymeric bone adhesives. Acta Biomater 8(1):313–320
Ardelean IL, Gudovan D, Ficai D, Ficai A, Andronescu E, Albu-Kaya MG, Neacsu P, Ion RN, Cimpean A, Mitran V (2018) Collagen/hydroxyapatite bone grafts manufactured by homogeneous/heterogeneous 3D printing. Mater Lett 231:179–182
Marques C, Ferreira JM, Andronescu E, Ficai D, Sonmez M, Ficai A (2014) Multifunctional materials for bone cancer treatment. Int J Nanomedicine 9:2713–2725
Pien N, Pezzoli D, Van Hoorick J, Copes F, Vansteenland M, Albu M, De Meulenaer B, Mantovani D, Van Vlierberghe S, Dubruel P (2021) Development of photo-crosslinkable collagen hydrogel building blocks for vascular tissue engineering applications: a superior alternative to methacrylated gelatin? Mater Sci Eng C Mater Biol Appl 130:112460
Noori A, Ashrafi SJ, Vaez-Ghaemi R, Hatamian-Zaremi A, Webster TJ (2017) A review of fibrin and fibrin composites for bone tissue engineering. Int J Nanomedicine 12:4937–4961
Lavik E, Langer R (2004) Tissue engineering: current state and perspectives. Appl Microbiol Biotechnol 65(1):1–8
Sun J, Tan H (2013) Alginate-based biomaterials for regenerative medicine applications. Materials (Basel) 6(4):1285–1309
Ribeiro VP, Pina S, Oliveira JM, Reis RL (25 April, 2018) Silk fibroin-based hydrogels and scaffolds for osteochondral repair and regeneration. In: Advanced experimental medicine biology (ed), vol 1058. Springer, Cham, pp 305–325
Aliramaji S, Zamanian A, Mozafari M (2017) Super-paramagnetic responsive silk fibroin/chitosan/magnetite scaffolds with tunable pore structures for bone tissue engineering applications. Mater Sci Eng C Mater Biol Appl 70(Pt 1):736–744
Li G, Sun S (2022) Silk fibroin-based biomaterials for tissue engineering applications. Molecules 27(9)
Yao X, Zou S, Fan S, Niu Q, Zhang Y (2022) Bioinspired silk fibroin materials: from silk building blocks extraction and reconstruction to advanced biomedical applications. Mater Today Bio 16:100381
Zhang Y, Ye S, Cao L, Lv Z, Ren J, Shao Z, Yao Y, Ling S (2022) Natural silk spinning-inspired meso-assembly-processing engineering strategy for fabricating soft tissue-mimicking biomaterials. Adv Func Mater 32(27):2200267
Ganesh N, Hanna C, Nair SV, Nair LS (2013) Enzymatically cross-linked alginic–hyaluronic acid composite hydrogels as cell delivery vehicles. Int J Biol Macromol 55:289–294
Muiznieks LD, Keeley FW (2013) Molecular assembly and mechanical properties of the extracellular matrix: a fibrous protein perspective. Biochim Biophys Acta 1832(7):866–875
Zarrintaj P, Manouchehri S, Ahmadi Z, Saeb MR, Urbanska AM, Kaplan DL, Mozafari M (2018) Agarose-based biomaterials for tissue engineering. Carbohydr Polym 187:66–84
Ressler A (22, 2022) Chitosan-based biomaterials for bone tissue engineering applications: a short review. Polymers (Basel), 14(16)
Xia Y, Wang D, Liu D, Su J, Jin Y, Wang D, Han B, Jiang Z, Liu B (2022) Applications of chitosan and its derivatives in skin and soft tissue diseases. Front Bioeng Biotechnol 10:894667
Yang Y, Campbell Ritchie A, Everitt NM (2021) Recombinant human collagen/chitosan-based soft hydrogels as biomaterials for soft tissue engineering. Mater Sci Eng C Mater Biol Appl 121:111846
Balagangadharan K, Dhivya S, Selvamurugan N (2017) Chitosan based nanofibers in bone tissue engineering. Int J Biol Macromol 104(Pt B):1372–1382
Nova A, Keten S, Pugno NM, Redaelli A, Buehler MJ (2010) Molecular and nanostructural mechanisms of deformation, strength and toughness of spider silk fibrils. Nano Lett 10(7):2626–2634
Sponner A, Vater W, Monajembashi S, Unger E, Grosse F, Weisshart K (2007) Composition and hierarchical organisation of a spider silk. PLoS ONE 2(10):e998
Vollrath F, Barth P, Basedow A, Engström W, List H (2002) Local tolerance to spider silks and protein polymers in vivo. In vivo (Athens, Greece) 16(4):229–234
Flores-Cano JV, Leyva-Ramos R, Mendoza-Barrón J, Guerrero-Coronado RM, Aragón-Piña A, Labrada-Delgado GJ (2013) Sorption mechanism of Cd(II) from water solution onto chicken eggshell. Appl Surf Sci 276:682–690
Gergely G, Weber F, Lukacs I, Toth AL, Horvath ZE, Mihaly J, Balazsi C (2010) Preparation and characterization of hydroxyapatite from eggshell. Ceram Int 36(2):803–806
Park HJ, Jeong SW, Yang JK, Kim BG, Lee SM (2007) Removal of heavy metals using waste eggshell. J Environ Sci 19(12):1436–1441
Ebaretonbofa E, Evans JRG (2002) High porosity hydroxyapatite foam scaffolds for bone substitute. J Porous Mater 9(4):257–263
Xu Y, Wang DZ, Yang L, Tang HG (2001) Hydrothermal conversion of coral into hydroxyapatite. Mater Charact 47(2):83–87
Dang W, Davlau T, Ylng P, Zhao Y, Nowotmk D, Clow CS, Tyler B, Brern H (1996) Effects of GLIADEL wafer initial molecular weight on the erosion of wafer and release of BCNU. J Control Release 42:89–92
Martin DP, Williams SF (2003) Medical applications of poly-4-hydroxybutyrate: a strong flexible absorbable biomaterial. Biochem Eng J 16(2):97–105
Sodian R, Sperling JS, Martin DP, Egozy A, Stock U, Mayer JE, Vacanti JP (2000) Fabrication of a trileaflet heart valve scaffold from a polyhydroxyalkanoate biopolyester for use in tissue engineering. Tissue Eng
Anseth KS, Metters AT, Bryant SJ, Martens PJ, Elisseeff JH, Bowman CN (2002) In situ forming degradable networks and their application in tissue engineering and drug delivery. J Control Release 78(1):199–209
Andronescu E, Nastase M, Ghitulica C, Stefan E (2002) Composite bioceramics. Euro Ceramics Vii, Pt 1–3(206–2):1591–1594
Balazsi C, Weber F, Kover Z, Horvath E, Nemeth C (2007) Preparation of calcium-phosphate bioceramics from natural resources. J Eur Ceram Soc 27(2–3):1601–1606
Filip N, Radu I, Veliceasa B, Filip C, Pertea M, Clim A, Pinzariu AC, Drochioi IC, Hilitanu RL, Serban IL (2022) Biomaterials in orthopedic devices: current issues and future perspectives. Coatings 12(10)
Zhou YL, Wu CT, Chang J (2019) Bioceramics to regulate stem cells and their microenvironment for tissue regeneration. Mater Today 24:41–56
Biomaterials (2019) National institutes of health, national institute of biomedical imaging and bioengineering
Elflein J (2021) Statistica—global number of organ transplantations 2019
Kosowska K, Domalik-Pyzik P, Sekula-Stryjewska M, Noga S, Jagiello J, Baran M, Lipinska L, Zuba-Surma E, Chlopek J (2020) Gradient chitosan hydrogels modified with graphene derivatives and hydroxyapatite: physiochemical properties and initial cytocompatibility evaluation. Int J Mol Sci 21(14)
Moizhess TG (2008) Carcinogenesis induced by foreign bodies. Biochem (Mosc) 73(7):763–775
Ducheyne P, Qiu Q (1999) Bioactive ceramics—the effect of surface reactivity on bone formation and bone cell function. Biomaterials 20:2287–2303
Hench LL (1998) Bioceramics. J Am Ceram Soc 8:1705–1728
Seala BL, Oterob TC, Panitcha A (2001) Polymeric biomaterials for tissue and organ regeneration. Mater Sci Eng R 34:147–230
LeVeen HH, Rarberio JR (1949) Tissue reaction to plastics used in surgery with special reference to teflon. Ann Surg 129:74–84
Hench LL (1988) Bioactive ceramics. Ann NY Acad Sci 523:54–71
Bettinger CJ (2009) Synthesis and microfabrication of biomaterials for soft-tissue engineering. Pure Appl Chem 81(12):2183–2201
Guo L, Liang Z, Yang L, Du W, Yu T, Tang H, Li C, Qiu H (2021) The role of natural polymers in bone tissue engineering. J Control Release 338:571–582
Todros S, Todesco M, Bagno A (2021) Biomaterials and their biomedical applications: from replacement to regeneration. Processes 9(11)
Grosberg A, Alford PW, McCain ML, Parker KK (2011) Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip. Lab Chip 11(24):4165–4173
Mohandas G, Oskolkov N, McMahon MT, Walczak P, Janowski M (2014) Porous tantalum and tantalum oxide nanoparticles for regenerative medicine. Acta Neurobiolgiae Experimentalis (Wars) 74(2):5688–5706
Niinomi M (2002) Recent metallic materials for biomedical applications. Metall Mater Trans A 33(3):477
Shah Idil A, Donaldson N (2018) The use of tungsten as a chronically implanted material. J Neural Eng 15(2):021006
Yoo YR, Cho HH, Jang SG, Lee KY, Son HY, Kim JG, Kim YS (2007) Effect of co-content on the corrosion of high performance stainless steels in simulated bio-solutions. Key Eng Mater 342–343:585–588
Kolos E, Ruys A (2015) Biomimetic coating on porous alumina for tissue engineering: characterisation by cell culture and confocal microscopy. Materials 8(6):3584–3606
Pieralli S, Kohal RJ, Jung RE, Vach K, Spies BC (2017) Clinical outcomes of zirconia dental implants: a systematic review. J Dent Res 96(1):38–46
Rahman SU (2020) Hydroxyapatite and tissue engineering. In: Handbook of ionic substituted hydroxyapatites, pp 383–400
Freed LE, Vunjak-Novakovic G, Biron RJ, Eagles DB, Lesnoy DC, Barlow SK, Langer R (1994) Biodegradable polymer scaffolds for tissue engineering. Bio/Technol 12:689–693
Kim BS, Sung HM, You HK, Lee J (2014) Effects of fibrinogen concentration on fibrin glue and bone powder scaffolds in bone regeneration. J Biosci Bioeng 118(4):469–475
Kim HD, Valentini RF (2002) Retention and activity of BMP-2 in hyaluronic acid-based scaffolds in vitro. J Biomed Mater Res 59(3):573–584
Seol YJ, Lee JY, Park YJ, Lee YM, Young K, Rhyu IC, Lee SJ, Han S-B, Chung C-P (2004) Chitosan sponges as tissue engineering scaffolds for bone formation. Biotechnol Lett 26:1037–1041
Kang E, Choi YY, Chae SK, Moon JH, Chang JY, Lee SH (2012) Microfluidic spinning of flat alginate fibers with grooves for cell-aligning scaffolds. Adv Mater 24(31):4271–4277
Shachar M, Tsur-Gang O, Dvir T, Leor J, Cohen S (2011) The effect of immobilized RGD peptide in alginate scaffolds on cardiac tissue engineering. Acta Biomater 7(1):152–162
Xie H, Gu Z, Li C, Franco C, Wang J, Li L, Meredith N, Ye Q, Wan C (2016) A novel bioceramic scaffold integrating silk fibroin in calcium polyphosphate for bone tissue-engineering. Ceram Int 42(2):2386–2392
Naresh K, Suyash N, Behzad F (2022) Additively manufactured porous Ti6Al4V for bone implants: a review. Metals 12(4)
Allo BA, Costa DO, Dixon SJ, Mequanint K, Rizkalla AS (2012) Bioactive and biodegradable nanocomposites and hybrid biomaterials for bone regeneration. J Funct Biomater 3(2):432–463
Anupam S (2011) An overview of metallic biomaterials for bone support and replacement, biomedical engineering, trends in materials science. In Laskovski A (ed). InTech China, pp 153–168
Mudali UK, Sridhar TM, Raj B (2003) Corrosion of bio implants. Sadhana 28(3&4):601–637
Ryan G, Pandit A, Apatsidis DP (2006) Fabrication methods of porous metals for use in Orthopaedic applications. Biomaterials 27(13):2651–2670
Behera A (2012) Classification of biomaterials used in medicine. Int J Adv Appl Sci 1(3):125–129
Billotte WC (2006) Ceramic biomaterials, pp 339.1–39.34
Tateish T (2007) Biomaterials in Asia: in commemoration of the 1st Asian biomaterials (Vol. ISBN: 13-978-981-283-574-1). World Scientific
Atala A (2008) Principles of regenerative medicine. Academic Press
Sarkar R, Banerjee G (2010) Ceramic based bio-medical implants. Interceram 59(2):98–102
Workie AB, Shih SJ (2022) Mesoporous bioactive glasses: synthesis, characterization, and their medical applications. Surf Rev Lett
Wu JJ, Wang SX, Zheng Z, Li JB (2022) Fabrication of biologically inspired electrospun collagen/silk fibroin/bioactive glass composited nanofibrous scaffold to accelerate the treatment efficiency of bone repair. Regenerative Ther 21:122–138
Yang ML, Yu S, Zhao P, Shi GF, Guo Y, Xie LW, Lyu G, Yu JJ (2022) Fabrication of biologically inspired electrospun collagen/silk fibroin/bioactive glass composited nanofibrous to accelerate the treatment efficiency of wound repair. Int Wound J
Akiyama Y, Ito M, Toriumi T, Hiratsuka T, Arai Y, Tanaka S, Futenma T, Akiyama Y, Yamaguchi K, Azuma A, Hata KI, Natsume N, Honda M (2021) Bone formation potential of collagen type I-based recombinant peptide particles in rat calvaria defects*. Regenerative Ther 16:12–22
Gassling V, Hedderich J, Acil Y, Purcz N, Wiltfang J, Douglas T (2013) Comparison of platelet rich fibrin and collagen as osteoblast-seeded scaffolds for bone tissue engineering applications. Clin Oral Implant Res 24(3):320–328
Geiger M, Li RH, Friess W (2003) Collagen sponges for bone regeneration with rhBMP-2. Adv Drug Deliv Rev 55(12):1613–1629
Santos TD, Abuna RPF, de Almeida ALG, Beloti MM, Rosa AL (2015) Effect of collagen sponge and fibrin glue on bone repair. J Appl Oral Sci 23(6):623–628
Lutolf MR, Weber FE, Schmoekel HG, Schense JC, Kohler T, Muller R, Hubbell JA (2003) Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nat Biotechnol 21(5):513–518
Schneider RK, Puellen A, Kramann R, Raupach K, Bornemann J, Knuechel R, Pérez-Bouza A, Neuss S (2010) The osteogenic differentiation of adult bone marrow and perinatal umbilical mesenchymal stem cells and matrix remodelling in three-dimensional collagen scaffolds. Biomaterials 31(3):467–480
Mehboob H, Chang S-H (2014) Application of composites to orthopedic prostheses for effective bone healing: a review. Compos Struct 118:328–341
Iftekhar A (2004) Biomedical composites. Standard handbook of biomedical engineering and design. McGraw-Hill Companies
Salernitano E, Migliaresi C (2018) Composite materials for biomedical applications: a review. J Appl Biomater Funct Mater 1(1):3–18
Ficai A, Andronescu E, Ghitulica C, Voicu G, Trandafir V, Manzu D, Ficai M, Pall S (2009) Collagen/hydroxyapatite interactions in composite biomaterials. Materiale Plastice 46(1):11–15
Ficai A, Andronescu E, Trandafir V, Ghitulica C, Voicu G (2010) Collagen/hydroxyapatite composite obtained by electric field orientation. Mater Lett 64(4):541–544
Ficai A, Andronescu E, Voicu G, Ghitulica C, Vasile BS, Ficai D, Trandafir V (2010) Self-assembled collagen/hydroxyapatite composite materials. Chem Eng J 160(2):794–800
Andronescu E, Voicu G, Ficai M, Mohora IA, Trusca R, Ficai A (2011) Collagen/hydroxyapatite composite materials with desired ceramic properties. J Electron Microsc (Tokyo) 60(3):253–259
Valtanen RS, Yang YP, Gurtner GC, Maloney WJ, Lowenberg DW (2021) Synthetic and bone tissue engineering graft substitutes: what is the future? Injury 52(Suppl 2):S72–S77
Levengood SKL, Zhang M (2014) Chitosan-based scaffolds for bone tissue engineering. J Mater Chem B 2(21):3161–3184. https://doi.org/10.1039/C4TB00027G
Wang F, Zhang YC, Zhou H, Guo YC, Su XX (2014) Evaluation of in vitro and in vivo osteogenic differentiation of nano-hydroxyapatite/chitosan/poly(lactide-co-glycolide) scaffolds with human umbilical cord mesenchymal stem cells. J Biomed Mater Res A 102(3):760–768
Lee CH, Singla A, Lee Y (2001) Biomedical applications of collagen. Int J Pharm 221:1–22
Schmidt CH, Baier JM (2000) Acellular vascular tissues: natural biomaterials for tissue repair and tissue engineering. Biomaterials 21:2215–2231
Andronescu E, Voicu G, Ficai M, Mohora IA, Trusca R, Ficai A (2011) Collagen/hydroxyapatite composite materials with desired ceramic properties. J Electron Microsc 60(3):253–259
Ficai A, Albu MG, Birsan M, Sonmez M, Ficai D, Trandafir V, Andronescu E (2013) Collagen hydrolysate based collagen/hydroxyapatite composite materials. J Mol Struct 1037:154–159
Nitti P, Kunjalukkal Padmanabhan S, Cortazzi S, Stanca E, Siculella L, Licciulli A, Demitri C (2021) Enhancing bioactivity of hydroxyapatite scaffolds using fibrous type I collagen. Front Bioeng Biotechnol 9:631177
Bian S, He M, Sui J, Cai H, Sun Y, Liang J, Fan Y, Zhang X (2016) The self-crosslinking smart hyaluronic acid hydrogels as injectable three-dimensional scaffolds for cells culture. Colloids Surf B Biointerfaces 140:392–402
Moreira CD, Carvalho SM, Mansur HS, Pereira MM (2016) Thermogelling chitosan-collagen-bioactive glass nanoparticle hybrids as potential injectable systems for tissue engineering. Mater Sci Eng C Mater Biol Appl 58:1207–1216
Prianka TR, Subhan N, Reza HM, Hosain MK, Rahman MA, Lee H, Sharker SM (2018) Recent exploration of bio-mimetic nanomaterial for potential biomedical applications. Mater Sci Eng C Mater Biol Appl 93:1104–1115
Reddy R, Reddy N (2018) Biomimetic approaches for tissue engineering. J Biomater Sci Polym Ed 29(14):1667–1685
Benyus JM (2009) Biomimicry: innovation inspired by nature. Pymble, NSW, Harper Collins
Feng C, Zhang W, Deng C, Li G, Chang J, Zhang Z, Jiang X, Wu C (2017) 3D printing of lotus root-like biomimetic materials for cell delivery and tissue regeneration. Adv Sci (Weinh) 4(12):1700401
Saruta J, Ozawa R, Okubo T, Taleghani SR, Ishijima M, Kitajima H, Hirota M, Ogawa T (2021) Biomimetic zirconia with cactus-inspired meso-scale spikes and nano-trabeculae for enhanced bone integration. Int J Mol Sci 22(15)
Gruber P (2009) Biomimetics in architecture—inspiration from plants 6th plant biomimetics conference—cayenne, November 16–21
Karageorgiou V, Kaplan D (2005) Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 26(27):5474–5491
Dearman BL, Boyce ST, Greenwood JE (2021) Advances in skin tissue bioengineering and the challenges of clinical translation. Front Surg 8:640879
Kuznetsova TA, Andryukov BG, Besednova NN (2022) Modern aspects of burn injury immunopathogenesis and prognostic immunobiochemical markers (Mini-Review). BioTech (Basel) 11(2)
Spoială A, Ilie C-I, Ficai D, Ficai A, Andronescu E (2022) Synergic effect of honey with other natural agents in developing efficient wound dressings. Antioxidants 12(1), Article 34
Raghunath M, Hopfner B, Aeschlimann D, Luthi U, Meuli M, Altermatt S, Gobet R, BrucknerTuderman L, Steinmann B (1996) Cross-linking of the dermo-epidermal junction of skin regenerating from keratinocyte autografts—anchoring fibrils are a target for tissue transglutaminase. J Clin Investig 98(5):1174–1184
Raghunath M, Meuli M (1997) Cultured epithelial autografts: diving from surgery into matrix biology. Pediatr Surg Int 12(7):478–483
Hinterhuber G, Marquardt Y, Diem E, Rappersberger K, Wolff K, Foedinger D (2002) Organotypic keratinocyte co-culture using normal human serum: an immunomorphological study at light and electron microscopic levels. Exp Dermatol 11(5):413–420
Braziulis E, Biedermann T, Hartmann-Fritsch F, Schiestl C, Pontiggia L, Bottcher-Haberzeth S, Reichmann E, Meuli M (2011) Skingineering I: engineering porcine dermo-epidermal skin analogues for autologous transplantation in a large animal model. Pediatr Surg Int 27(3):241–247
Biedermann T, Bottcher-Haberzeth S, Klar AS, Pontiggia L, Schiestl C, Meuli-Simmen C, Reichmann E, Meuli M (2013) Rebuild, restore, reinnervate: do human tissue engineered dermo-epidermal skin analogs attract host nerve fibers for innervation? Pediatr Surg Int 29(1):71–78
Biedermann T, Klar AS, Bottcher-Haberzeth S, Schiestl C, Reichmann E, Meuli M (2014) Tissue-engineered dermo-epidermal skin analogs exhibit de novo formation of a near natural neurovascular link 10 weeks after transplantation. Pediatr Surg Int 30(2):165–172
Hartmann-Fritsch F, Biedermann T, Braziulis E, Luginbuhl J, Pontiggia L, Bottcher-Haberzeth S, van Kuppevelt TH, Faraj KA, Schiestl C, Meuli M, Reichmann E (2016) Collagen hydrogels strengthened by biodegradable meshes are a basis for dermo-epidermal skin grafts intended to reconstitute human skin in a one-step surgical intervention. J Tissue Eng Regen Med 10(1):81–91
Pontiggia L, Van Hengel IAJ, Klar A, Rutsche D, Nanni M, Scheidegger A, Figi S, Reichmann E, Moehrlen U, Biedermann T (2022) Bioprinting and plastic compression of large pigmented and vascularized human dermo-epidermal skin substitutes by means of a new robotic platform. J Tissue Eng 13
Qiang A (2016) Progress of nerve bridges in the treatment of peripheral nerve disruptions. J Neurorestoratology 4:107–113
Abdelbasset WK, Jasim SA, Sharma SK, Margiana R, Bokov DO, Obaid MA, Hussein BA, Lafta HA, Jasim SF, Mustafa YF (2022) Alginate-based hydrogels and tubes, as biological macromolecule-based platforms for peripheral nerve tissue engineering: a review. Ann Biomed Eng 50(6):628–653
Gu XK, Yi S, Deng AD, Liu H, Xu L, Gu JH, Gu XS (2022) Combined use of chitosan-PGLA nerve grafts and bone marrow mononuclear cells to repair a 50-mm-long median nerve defect combined with an 80-mm-long ulnar nerve defect in the human upper arm. Curr Stem Cell Res Ther 17(4):389–397
Khan HM, Liao XX, Sheikh BA, Wang YX, Su ZX, Guo C, Li ZY, Zhou CC, Cen Y, Kong QQ (2022) Smart biomaterials and their potential applications in tissue engineering. J Mater Chem B 10(36):6859–6895
Nune M, Bhat M, Nagarajan A (2022) Design of ECM functionalized polycaprolactone aligned nanofibers for peripheral nerve tissue engineering. J Med Biol Eng 42(2):147–156
Wang B, Lu CF, Liu ZY, Han S, Wei P, Zhang DY, Kou YH, Jiang BG (2022) Chitin scaffold combined with autologous small nerve repairs sciatic nerve defects. Neural Regeneration Res 17(5):1106-+
Zeng ZP, Yang YJ, Deng JY, Rahman MSU, Sun CM, Xu SS (2022) Physical stimulation combined with biomaterials promotes peripheral nerve injury repair. Bioeng-Basel 9(7). https://doi.org/10.3390/bioengineering9070292
Zhang FS, Zhang M, Liu SY, Li C, Ding ZT, Wan T, Zhang PX (2022) Application of hybrid electrically conductive hydrogels promotes peripheral nerve regeneration. Gels 8(1)
Zhang LL, Zheng TT, Wu LL, Han Q, Chen SY, Kong Y, Li GC, Ma L, Wu H, Zhao YH, Yu YX, Yang YM (2021) Fabrication and characterization of 3D-printed gellan gum/starch composite scaffold for Schwann cells growth. Nanotechnol Rev 10(1):50–61
Zhang XD, Meng YX, Gong BW, Wang T, Lu YL, Zhang LQ, Xue JJ (2022) Electrospun nanofibers for manipulating soft tissue regeneration. J Mater Chem B 10(37):7281–7308
Lin B, Dun G, Jin D, Du Y (2019) Development of polypyrrole/collagen/nano-strontium substituted bioactive glass composite for boost sciatic nerve rejuvenation in vivo. Artif Cells Nanomed Biotechnol 47(1):3423–3430
Nerem RM, Ensley AE (2004) The tissue engineering of blood vessels and the heart. Am J Transplant 4(Suppl 6):36–42
Bertanha M, Moroz A, Almeida R, Alves FC, Acorci Valerio MJ, Moura R, Domingues MA, Sobreira ML, Deffune E (2014) Tissue-engineered blood vessel substitute by reconstruction of endothelium using mesenchymal stem cells induced by platelet growth factors. J Vasc Surg 59(6):1677–1685
Copes F, Pien N, Van Vlierberghe S, Boccafoschi F, Mantovani D (2019) Collagen-based tissue engineering strategies for vascular medicine. Front Bioeng Biotechnol 7:166
Antunes M, Bonani W, Reis RL, Migliaresi C, Ferreira H, Motta A, Neves NM (2022) Development of alginate-based hydrogels for blood vessel engineering. Biomater Adv 134:112588
Idaszek J, Volpi M, Paradiso A, Nguyen Quoc M, Górecka Ż, Klak M, Tymicki G, Berman A, Wierzbicki M, Jaworski S, Costantini M, Kępczyńska A, Chwalibóg ES, Wszoła M, Święszkowski W (2021) Alginate-based tissue-specific bioinks for multi-material 3D-bioprinting of pancreatic islets and blood vessels: a step towards vascularized pancreas grafts. Bioprinting 24:e00163
Du J, Hu X, Su Y, Wei T, Jiao Z, Liu T, Wang H, Nie Y, Li X, Song K (2022) Gelatin/sodium alginate hydrogel-coated decellularized porcine coronary artery to construct bilayer tissue engineered blood vessels. Int J Biol Macromol 209(Pt B):2070–2083
Brewster L, Brey EM, Greisler HP (2014) Blood vessels, pp 793–812
Scherner M, Reutter S, Klemm D, Sterner-Kock A, Guschlbauer M, Richter T, Langebartels G, Madershahian N, Wahlers T, Wippermann J (2014) In vivo application of tissue-engineered blood vessels of bacterial cellulose as small arterial substitutes: proof of concept? J Surg Res 189(2):340–347
Michael PL, Yang NJ, Moore M, Santos M, Lam YT, Ward A, Hung JC, Tan RP, Wise SG (2022) Synthetic vascular graft with spatially distinct architecture for rapid biomimetic cell organisation in a perfusion bioreactor. Biomed Mater 17(4)
Amukarimi S, Ramakrishna S, Mozafari M (2021) Smart biomaterials—a proposed definition and overview of the field. Curr Opin Biomed Eng 19
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Spoială, A., Ilie, CI., Ficai, D., Ficai, A. (2023). Biomaterials. In: Gunduz, O., Egles, C., Pérez, R.A., Ficai, D., Ustundag, C.B. (eds) Biomaterials and Tissue Engineering. Stem Cell Biology and Regenerative Medicine, vol 74. Springer, Cham. https://doi.org/10.1007/978-3-031-35832-6_4
Download citation
DOI: https://doi.org/10.1007/978-3-031-35832-6_4
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-35831-9
Online ISBN: 978-3-031-35832-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)