Abstract
Infective endocarditis (IE) is infection of a native or prosthetic heart valve, endocardial surface, or indwelling cardiac device. IE most commonly occurs on native heart valves 72%, followed by prosthetic valves 21%, and finally pacemaker/ICD 7% (Murdoch, Arch Int Med 169:463, 2009). The incidence of IE varies worldwide but is still relatively low at 3–10 cases per 100,000 people (Cahill et al., Lancet 387:882–893, 2016). Despite this low incidence, untreated IE carries a high in-hospital mortality rate of 15–20% and a 1-year mortality rate close to 40% (Otto et al., Circulation 2021(143):e72–e227, 2020). Diagnosis requires careful attention to symptoms, physical exam, and diagnostic imaging. Prompt diagnosis and treatment are key to reducing mortality.
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References
Mann, et al. Braunwald’s Heart Disease. A textbook of cardiovascular medicine. 10th ed. Elsevier.
Otto CM, et al. ACC/AHA guideline for the management of valvular heart disease. Circulation. 2020;2021(143):e72–e227.
Nataloni M, et al. Prosthetic valve endocarditis. J Cardiovasc Med. 11:869–83.
Wang A, et al. Management considerations in infective endocarditis: a review. JAMA. 2018;320(1):72–83.
Chambers, et al. Native-valve infective endocarditis. N Engl J Med. 2020;383:567–76.
Baddour LM, et al. Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications. Circulation. 2015;132:1435–86.
Murdoch DR. Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century. Arch Intern Med. 2009;169(5):463. https://doi.org/10.1001/archinternmed.2008.603.
Cahill TJ, et al. Infective endocarditis. Lancet. 2016;387:882–93.
UpToDate: overview of management of infective endocarditis in adults.
Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP III, Gentile F. 2020 ACC/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2021;77(4):e25–197.
UpToDate: antimicrobial therapy of left-sided native valve endocarditis.
The Society of Thoracic Surgeons; 2022. Available from: https://www.sts.org/resources/riskcalculator.
Shmueli H, Thomas F, Flint N, Setia G, Janjic A, Siegel RJ. Right-sided infective endocarditis 2020: challenges and updates in diagnosis and treatment. J Am Heart Assoc. 2020;9(15).
Bonow RO, O’Gara PT, Adams DH, Badhwar V, Bavaria JE, Elmariah S, et al. 2019 AATS/ACC/SCAI/STS expert consensus systems of care document: operator and institutional recommendations and requirements for transcatheter mitral valve intervention. J Am Coll Cardiol. 2020;76(1):96–117.
Lawton JS, Tamis-Holland JE, Bangalore S, Bates ER, Beckie TM, Mischoff JM, et al. 2021 ACC/AHA/SCAI Guideline for Coronary artery Revascularization, A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2022;79(2):e21–e129.
Chung J, Shum-Tim D. The current indications and options for aortic valve surgery. J Surg. 2014;2(1):6.
Fedak PWM, McCarthy PM, Bonow RO. Evolving concepts and technologies in mitral valve repair. Circulation. 2008;117(7):963–74.
Watts TMF, Brescia AA, Murray SL, Burn DA, Wisniewski A, Romano MA. Degenerative mitral valve repair restores life expectancy. Ann Thorac Surg. 2020;109(3):494–801.
UpToDate: clinical Manifestations and evaluation of adults with suspected left-sided native valve endocarditis.
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Stephens, A., McVeigh, T., Ward, C., Powell, E.A., Watts, L. (2023). Infective Endocarditis. In: Musialowski, R., Allshouse, K. (eds) Cardiovascular Manual for the Advanced Practice Provider. Springer, Cham. https://doi.org/10.1007/978-3-031-35819-7_19
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DOI: https://doi.org/10.1007/978-3-031-35819-7_19
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