Abstract
Self-assembled nanostructured materials are gaining popularity due to their extensive applications in the fields of nanotechnology, biosensing, biomedical sciences, imaging techniques, etc. This is mainly attributed to its simplicity, low cost, spontaneity, scalability, versatility, and yield technique with a wide range of scientific and technological applications. This chapter presents different means of characterizing self-organizing structures using several techniques to investigate their properties. Molecular self-assembly depends on chemical complementarity and structural compatibility. In this chapter, the mechanisms of molecular self-assembly will be discussed. The weak non-covalent bonds like electrostatic interactions, hydrogen bonds, hydrophobic and hydrophilic interactions, water-mediated hydrogen bonds, and van der Waals interactions will be explained. The benefits of using self-assembled nanostructured materials in molecular medicine will be addressed. The focus here is mainly on the applications related to molecular medicine leading to targeted drug delivery. The chapter also discusses the challenges encountered and suitable solutions that need to be approached extensively. These will be addressed specifically in relation to molecular medicine applications and drug delivery systems.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ahmed, E. M. (2015). Hydrogel: Preparation, characterization, and applications: A review. Journal of Advanced Research, 6(2), 105–121.
Ariga, K., Nishikawa, M., Mori, T., Takeya, J., Shrestha, L. K., & Hill, J. P. (2019 Jan 31). Self-assembly as a key player for materials nanoarchitectonics. Science and Technology of Advanced Materials, 20(1), 51–95.
Castillo-León, J., Andersen, K. B., & Svendsen, W. E. (2011). Self–assembled peptide nanostructures for biomedical applications: Advantages and challenges. Biomaterials Science and Engineering, 10, 23322.
Chen, J., Guo, L., Qiu, B., Lin, Z., & Wang, T. (2018). Application of ordered nanoparticle self-assemblies in surface-enhanced spectroscopy. Materials Chemistry Frontiers, 2(5), 835–860.
Delfi, M., Sartorius, R., Ashrafizadeh, M., Sharifi, E., Zhang, Y., De Berardinis, P., Zarrabi, A., Varma, R. S., Tay, F. R., Smith, B. R., & Makvandi, P. (2021). Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy. Nano Today, 38, 101119.
Gao, X., & Matsui, H. (2005). Peptide-based nanotubes and their applications in bionanotechnology. Advanced Materials, 17(17), 2037–2050. https://doi.org/10.1002/adma.200401849
Habibi, N., Kamaly, N., Memic, A., & Shafiee, H. (2016). Self-assembled peptide-based nanostructures: Smart nanomaterials toward targeted drug delivery. Nano Today, 11(1), 41–60.
Huynh, N. T., Passirani, C., Saulnier, P., & Benoit, J. P. (2009). Lipid nanocapsules: a new platform for nanomedicine. International Journal of Pharmaceutics, 379(2), 201–209.
Jeevanandam, J., Barhoum, A., Chan, Y. S., Dufresne, A., & Danquah, M. K. (2018). Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations. Beilstein Journal of Nanotechnology, 9, 1050–1074.
Kasotakis, E., Mossou, E., Adler-Abramovich, L., Mitchell, E. P., Forsyth, V. T., Gazit, E., & Mitraki, A. (2009). Design of metal-binding sites onto self-assembled peptide fibrils. Peptide Science: Original Research on Biomolecules, 92(3), 164–172.
Kochovski, Z., Chen, G., Yuan, J., & Lu, Y. (2020). Cryo-Electron microscopy for the study of self-assembled poly(ionic liquid) nanoparticles and protein supramolecularstructures. Colloid & Polymer Science, 298, 707–717.
Koshy, O. (2017). Differential scanning calorimetry in nanoscience and nanotechnology. In Thermal and rheological measurement techniques for nanomaterials characterization (pp. 109–122). Elsevier.
Lee, S., Trinh, T. H. T., Yoo, M., Shin, J., Lee, H., Kim, J., Hwang, E., Lim, Y. B., & Ryou, C. (2019). Self-assembling peptides and their application in the treatment of diseases. International Journal of Molecular Sciences, 20(23), 5850.
Li, J. (2017). Supramolecular chemistry of biomimetic systems. Advantages of self-assembled supramolecular polymers toward biological applications (pp. 9–35). Springer. https://doi.org/10.1007/978-981-10-6059-5
Lu, W. (2012). Self-assembly of nanostructures. In B. Bhushan (Ed.), Encyclopedia of nanotechnology. Springer.
Mourdikoudis, S., Pallares, R. M., & Thanh, N. T. K. (2018). Characterization techniques for nanoparticles: comparison and complementarity upon studying nanoparticle properties. Nanoscale, 10, 12871–12934.
Nie, Z., Petukhova, A., & Kumacheva, E. (2010). Properties and emerging applications of self-assembled structures made from inorganic nanoparticles. Nature Nanotechnology, 5(1), 15–25.
Pignatello, R. (2011). Self-assembled peptide nanostructures for biomedical applications: Advantages and challenges. Biomaterials Science and Engineering. https://doi.org/10.5772/1956
Puri, A., Loomis, K., Smith, B., Lee, J. H., Yavlovich, A., Heldman, E., & Blumenthal, R. (2009). Lipid-based nanoparticles as pharmaceutical drug carriers: From concepts to clinic. Critical Reviews in Therapeutic Drug Carrier Systems, 26(6), 523–580.
Scioli Montoto, S., Muraca, G., & Ruiz, M. E. (2020). Solid lipid nanoparticles for drug delivery: pharmacological and biopharmaceutical aspects. Frontiers in Molecular Biosciences, 7, 587997.
Stephen, V. J., Andrew, M. R., Nigel, R. H., Hodson, W., Saiani, A., Gough, J. E., & Ulijin, V. (2009). Introducing chemical functionality in Fmoc-peptide gels for cell culture. Acta Biomaterialia, 5(3), 934–943.
Subramani, K., & Ahmed, W. (2018). Self-assembly of proteins and peptides and their applications in bionanotechnology and dentistry. In Emerging nanotechnologies in dentistry (pp. 231–249). William Andrew Publishing.
Suhail, N., Alzahrani, A. K., Basha, W. J., Kizilbash, N., Zaidi, A., Ambreen, J., & Khachfe, H. M. (2021). Microemulsions: Unique properties, pharmacological applications, and targeted drug delivery. Frontiers in Nanotechnology, 69.
Tan, A., Hong, L., Du, J. D., & Boyd, B. J. (2019). Self-assembled nanostructured lipid systems: is there a link between structure and cytotoxicity? Advanced Science, 6(3), 1801223.
Wang, L., Gong, C., Yuan, X., & Wei, G. (2019). Controlling the self-assembly of biomolecules into functional nanomaterials through internal interactions and external stimulations: A review. Nanomaterials (Basel), 9(2), 285.
Zhang, S. (2002). Emerging biological materials through molecular self-assembly. Biotechnology Advances, 20(5–6), 321–339.
Zuccheri, G., & Samorì, B. (2011). Methods in molecular biology; DNA nanotechnology. In Synthesis and characterization of self-assembled DNA nanostructures (Chapter 1) (Vol. 749, pp. 1–11). https://doi.org/10.1007/978-1-61779-142-0
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Sowmya, S.V., Pushpalatha, C., Augustine, D., Singh, I., Shakir, A., Dhodwad, R. (2023). Benefits of Molecular Medicine from Self-Assembled Nanostructured Materials. In: Pal, K. (eds) Nanovaccinology. Springer, Cham. https://doi.org/10.1007/978-3-031-35395-6_6
Download citation
DOI: https://doi.org/10.1007/978-3-031-35395-6_6
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-35394-9
Online ISBN: 978-3-031-35395-6
eBook Packages: MedicineMedicine (R0)