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Dermatologic Changes Related to Patients with Obstructive Sleep Apnea

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Obstructive Sleep Apnea

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Abstract

Skin disorders are a common comorbidity of sleep apnea, and sleep apnea itself may deteriorate the skin. Obstructive sleep apnea (OSA) is an inflammatory disease that is associated with obesity and mechanical obstruction of the airways leading to episodes of tissue hypoxia. This chapter reviews the literature on the association between OSA and dermatologic disorders. Four etiopathogenic mechanisms may explain the relationship of many dermatologic processes with OSA: systemic bidirectional inflammation associated with OSA and inflammatory skin disease (best exemplified by psoriasis and atopic dermatitis) in which each condition exacerbates the other; obesity itself and the conditions associated (diabetes, hidradenitis suppurativa, polycystic ovary syndrome); mechanical obstruction of the upper airways; and finally, the hypoxia related to OSA may be associated with skin cancer, in particular melanoma. Many of these associations are clear and have been well studied and documented. However, more research is needed to describe better the mechanisms underlying the clinical associations between skin diseases and OSA and the potential therapeutic effects on skin diseases when treating OSA with CPAP or other interventions.

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References

  1. American Academy of Sleep Medicine. International classification of sleep disorders. 3rd ed. Darien, IL: American Academy of Sleep Medicine; 2014.

    Google Scholar 

  2. Jennum P, Ibsen R, Kjellberg J. Morbidity prior to a diagnosis of sleep-disordered breathing: a controlled national study. J Clin Sleep Med. 2013;9:103–8.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Jennum P, Ibsen R, Kjellberg J. Morbidity and mortality in children with obstructive sleep apnoea: a controlled national study. Thorax. 2013;68:949–54.

    Article  PubMed  Google Scholar 

  4. Drager LF, Togeiro SM, Polotsky VY, et al. Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome. J Am Coll Cardiol. 2013;62:569–76.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Gupta MA, Gupta AK. Psychiatric and psychological co-morbidity in patients with dermatologic disorders: epidemiology and management. Am J Clin Dermatol. 2003;4:833–42.

    Article  PubMed  Google Scholar 

  6. Gupta MA, Simpson FC. Obstructive sleep apnea and psychiatric disorders: a systematic review. J Clin Sleep Med. 2015;11:165–75.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Gupta MA, Gupta AK. Sleep-wake disorders and dermatology. Clin Dermatol. 2013;31:118–26.

    Article  PubMed  Google Scholar 

  8. Savransky V, Jun J, Li J, et al. Dyslipidemia and atherosclerosis induced by chronic intermittent hypoxia are attenuated by deficiency of stearoyl coenzyme A desaturase. Circ Res. 2008;103:1173–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. McNicholas WT, Bonsigore MR. Management Committee of ECAB. Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities. Eur Respir J. 2007;29:156–78.

    Article  CAS  PubMed  Google Scholar 

  10. Hirotsu C, Nogueira H, Albuquerque RG, Tomimori J, Tufik S, Andersen ML. The bidirectional interactions between psoriasis and obstructive sleep apnea. Int J Dermatol. 2015;54:1352–8.

    Article  PubMed  Google Scholar 

  11. Gaines J, Vgontzas AN, Fernandez-Mendoza J, et al. Inflammation mediates the association between visceral adiposity and obstructive sleep apnea in adolescents. Am J Physiol Endocrinol Metab. 2016;311:E851–8.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Can M, Uygur F, Tanriverdi H, et al. Effect of continuous positive airway pressure (CPAP) therapy on IL-23 in patients with obstructive sleep apnea. Immunol Res. 2016;64:1179–84.

    Article  CAS  PubMed  Google Scholar 

  13. Phillips BG, Wang Y, Ambati S, Ma P, Meagher RB. Airways therapy of obstructive sleep apnea dramatically improves aberrant levels of soluble cytokines involved in autoimmune disease. Clin Immunol. 2020;221:108601.

    Article  CAS  PubMed  Google Scholar 

  14. Polat D, Demirtaş E, Ahmet B, Yarali H. Decreased serum paraoxonase 1 (PON1) activity: an additional risk factor for atherosclerotic heart disease in patients with PCOS? Hum Reprod. 2006;21:104–8.

    Article  Google Scholar 

  15. Van Cauter E. Sleep disturbances and insulin resistance. Diabet Med. 2011;28:1455–62.

    Article  PubMed  Google Scholar 

  16. Gupta MA, Simpson FC, Gupta AK. Psoriasis and sleep disorders: a systematic review. Sleep Med Rev. 2015;29:63–75.

    Article  PubMed  Google Scholar 

  17. Gowda S, Goldblum OM, McCall WV, et al. Factors affecting sleep quality in patients with psoriasis. J Am Acad Dermatol. 2010;63:114–23.

    Article  PubMed  Google Scholar 

  18. Machado-Pinto J, Diniz Mdos S, Bavoso NC. Psoriasis: new comorbidities. An Bras Dermatol. 2016;91:8–14.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Egeberg A, Khalid U, Gislason GH, et al. Psoriasis and sleep apnea: a Danish nationwide cohort study. J Clin Sleep Med. 2016;12:663–71.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Bissonnette R, Maari C, Bolduc C, et al. Prevalence of obstructive sleep apnea in obese patients with psoriasis. J Am Acad Dermatol. 2012;66:AB133.

    Google Scholar 

  21. Chiu HY, Hsieh CF, Chiang YT, et al. Concomitant sleep disorders significantly increase the risk of cardiovascular disease in patients with psoriasis. PloS One. 2016;11:e0146462.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Cohen JM, Jackson CL, Li TY, et al. Sleep disordered breathing and the risk of psoriasis among US women. Arch Dermatol Res. 2015;307:433–8.

    Article  PubMed  Google Scholar 

  23. Duffin KC, Woodcock J, Walsh J, et al. Increased prevalence of sleep apnea in patients with psoriasis compared to matched controls. Clin Transl Sci. 2012;5:170.

    Google Scholar 

  24. Papadavid E, Vlami K, Dalamaga M, et al. Sleep apnea as a comorbidity in obese psoriasis patients: a cross-sectional study. Do psoriasis characteristics and metabolic parameters play a role? J Eur Acad Dermatol Venereol. 2013;27:820–6.

    Article  CAS  PubMed  Google Scholar 

  25. Tsai TF, Wang TS, Hung ST, et al. Epidemiology and comorbidities of psoriasis patients in a national database in Taiwan. J Dermatol Sci. 2011;63:40–6.

    Article  PubMed  Google Scholar 

  26. Yang YW, Kang JH, Lin HC. Increased risk of psoriasis following obstructive sleep apnea: a longitudinal population-based study. Sleep Med. 2012;13:285–9.

    Article  PubMed  Google Scholar 

  27. Papadavid E, Dalamaga M, Vlami K, Koumaki D, Gyftopoulos S, Christodoulatos GS, et al. Psoriasis is associated with risk of obstructive sleep apnea independently from metabolic parameters and other comorbidities: a large hospital-based case-control study. Sleep Breath. 2017;21:949–58.

    Article  PubMed  Google Scholar 

  28. Shalom G, Dreiher J, Cohen A. Psoriasis and obstructive sleep apnea. Int J Dermatol. 2016;55:e579–84.

    Article  PubMed  Google Scholar 

  29. Castello-Branco RC, Cerqueira-Silva T, Andrade AL, Gonçalves BM, Pereira CB, Felix IF, Santos LS, Porto LM, Marques ME, Catto MB, et al. Association between risk of obstructive sleep apnea and cerebrovascular reactivity in stroke patients. J Am Heart Assoc. 2020;9:e015313.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Saçmaci H, Gürel G. Sleep disorders in patients with psoriasis: across-sectional study using non-polysomnographical methods. Sleep Breath. 2019;23:893–8.

    Article  PubMed  Google Scholar 

  31. Gabryelska A, Białasiewicz P. Is autonomic activation a middleman between obstructive sleep apnea syndrome and psoriasis? J Clin Sleep Med. 2018;14:1087–8.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Gowda S, Goldblum OM, McCall WV, Feldman SR. Factors affecting sleep quality in patients with psoriasis. J Am Acad Dermatol. 2010;63:114–23.

    Article  PubMed  Google Scholar 

  33. Maari C, Bolduc C, Nigen S, Marchessault P, Bissonnette R. Effect of adalimumab on sleep parameters in patients with psoriasis and obstructive sleep apnea: a randomized controlled trial. J Dermatol Treat. 2014;25:57–60.

    Article  CAS  Google Scholar 

  34. Vakil M, Park S, Broder A. The complex associations between obstructive sleep apnea and auto-immune disorders: a review. Med Hypotheses. 2018;110:138–43.

    Article  PubMed  Google Scholar 

  35. Kim J, Kim BE, Leung DYM. Pathophysiology of atopic dermatitis: Clinical implications. Allergy Asthma Proc. 2019;40:84–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Cabanillas B, Brehler AC, Novak N. Atopic dermatitis phenotypes and the need for personalized medicine. Curr Opin Allergy Clin Immunol. 2017;17:309–15.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Darsow U, Raap U, Ständer S. Atopic dermatitis. In: Carstens E, Akiyama T, editors. Itch: mechanisms and treatment. Boca Raton, FL: CRC Press; 2014. Chapter 3.

    Google Scholar 

  38. Wolter S, Price HN. Atopic dermatitis. Pediatr Clin North Am. 2014;61:241–60.

    Article  PubMed  Google Scholar 

  39. Tien KJ, Chou CW, Lee SY, Yeh NC, Yang CY, Yen FC, et al. Obstructive sleep apnea and the risk of atopic dermatitis: a population-based case control study. PloS One. 2014;9:e89656.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Arens R, Marcus CL. Pathophysiology of upper airway obstruction: a developmental perspective. Sleep. 2004;27:997–1019.

    Article  PubMed  Google Scholar 

  41. Olusesi AD, Undie NB, Amodu JE. Allergy history as a predictor of early onset adenoids/adenotonsillar hypertrophy among Nigerian children. Int J Pediatr Otorhinolaryngol. 2013;77:1032–5.

    Article  PubMed  Google Scholar 

  42. Alexopoulos EI, Bizakis J, Gourgoulianis K, Kaditis AG. Atopy does not affect the frequency of adenotonsillar hypertrophy and sleep apnoea in children who snore. Acta Paediatr. 2014;103:1239–43.

    Article  PubMed  Google Scholar 

  43. Huo Z, Shi J, Shu Y, Xiang M, Lu J, Wu H. The relationship between allergic status and adenotonsillar regrowth: a retrospective research on children after adenotonsillectomy. Sci Rep. 2017;7:46,615.

    Article  CAS  Google Scholar 

  44. Kheirandish-Gozal L, Bandla HP, Gozal D. Montelukast for children with obstructive sleep apnea: results of a double-blind, randomized, placebo-controlled trial. Ann Am Thorac Soc. 2016;13:1736–41.

    PubMed  PubMed Central  Google Scholar 

  45. Dayyat E, Serpero LD, Kheirandish-Gozal L, Goldman JL, Snow A, Bhattacharjee R, et al. Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive sleep apnea. Chest. 2009;135:1142–9.

    Article  CAS  PubMed  Google Scholar 

  46. Fishbein AB, Lor J, Penedo FJ, Forrest CB, Griffith JW, Paller AS. Patient-reported outcomes for measuring sleep disturbance in pediatric atopic dermatitis: cross sectional study of PROMIS pediatric sleep measures and actigraphy. J Am Acad Dermatol. 2020;

    Google Scholar 

  47. Association between obstructive sleep apnea and atopic dermatitis in children: a nationwide, population-based cohort study. Pediatr Allergy Immunol. 2018;29:260–6.

    Google Scholar 

  48. Fishbein AB, Mueller K, Kruse L, Boor P, Sheldon S, Zee P, et al. Sleep disturbance in children with moderate/severe atopic dermatitis: a case-control study. J Am Acad Dermatol. 2018;78:336–41.

    Article  PubMed  Google Scholar 

  49. Treister AD, Stefek H, Grimaldi D, Rupani N, Zee P, Yob J, et al. Sleep and limb movement characteristics of children with atopic dermatitis coincidentally undergoing clinical polysomnography. J Clin Sleep Med. 2019;15:1107–13.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Reuveni H, Chapnick G, Tal A, et al. Sleep fragmentation in children with atopic dermatitis. Arch Pediatr Adolesc Med. 1999;153:249–53.

    Article  CAS  PubMed  Google Scholar 

  51. Bozkurt B, Serife Ugur K, Karamanli H, et al. Polysomnographic findings in persistent allergic rhinitis. Sleep Breath. 2016. [Epub ahead of print].

    Google Scholar 

  52. Tahrani AA, Ali A, Raymond NT, Begum S, Dubb K, Mughal S, et al. Obstructive sleep apnea and diabetic neuropathy: a novel association in patients with type 2 diabetes. Am J Respir Crit Care Med. 2012;186:434–41.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Altaf QA, Ali A, Piya MK, Raymond NT, Tahrani AA. The relationship between obstructive sleep apnea and intra-epidermal nerve fiber density, PARP activation and foot ulceration in patients with type 2 diabetes. J Diabetes Complications. 2016;30:1315–20.

    Article  PubMed  Google Scholar 

  54. Vas PR, Ahluwalia R, Manas AB, Manu CA, Kavarthapu V, Edmonds ME. Undiagnosed severe sleep apnoea and diabetic foot ulceration—a case series based hypothesis: a hitherto under emphasized factor in failure to heal. Diabet Med. 2016;33:e1–4.

    Article  CAS  PubMed  Google Scholar 

  55. van der Zee HH, de Ruiter L, van den Broecke DG, et al. Elevated levels of tumour necrosis factor (TNF)-a, interleukin (IL)-1b and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-a and IL-1b. Br J Dermatol. 2011;164:1292–8.

    Article  PubMed  Google Scholar 

  56. Alberti A, Sarchielli P, Gallinella E, et al. Plasma cytokine levels in patients with obstructive sleep apnea syndrome: a preliminary study. J Sleep Res. 2003;12:305–11.

    Article  PubMed  Google Scholar 

  57. Irwin MR, Olmstead R, Carroll JE. Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol Psychiatry. 2016;80:40–52.

    Article  PubMed  Google Scholar 

  58. Wertenteil S, Strunk A, Garg A. Incidence of obstructive sleep apnoea in patients with hidradenitis suppurativa: a retrospective population-based cohort analysis. Br J Dermatol. 2018;179:1398–9.

    Article  CAS  PubMed  Google Scholar 

  59. Vinkel C, Thomsen SF. Risk factors for cardiovascular disease in patients with hidradenitis suppurativa. J Eur Acad Dermatol Venereol. 2017;31:e411–3.

    Article  CAS  PubMed  Google Scholar 

  60. Drager LF, Togeiro SM, Polotsky VY, Lorenzi-Filho G. Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome. J Am Coll Cardiol. 2013;62:569–76.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Matusiak L, Bieniek A, Szepietowski JC. Increased serum tumour necrosis factor-alpha in hidradenitis suppurativa patients: is there a basis for treatment with anti-tumour necrosis factor-alpha agents? Acta Dermatovenereol. 2009;89:601–3.

    CAS  Google Scholar 

  62. Kelly A, Meurling J, Kirthi Jeyarajah S, Ryan C, Hughes R, Garvey J, Kirby B. Obstructive sleep apnoea in psoriasis and hidradenitis suppurativa. Br J Dermatol. 2021;184:1183–5.

    Article  CAS  PubMed  Google Scholar 

  63. Fogel RB, Malhotra A, Pillar G, et al. Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2001;86:1175–80.

    CAS  PubMed  Google Scholar 

  64. Vgontzas AN, Legro RS, Bixler EO, et al. Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance. J Clin Endocrinol Metab. 2001;86:517–20.

    CAS  PubMed  Google Scholar 

  65. Tasali E, Van Cauter E, Ehrmann DA. Relationships between sleep disordered breathing and glucose metabolism in polycystic ovary syndrome. J Clin Endocrinol Metab. 2006;91:36–42.

    Article  CAS  PubMed  Google Scholar 

  66. Gopal M, Duntley S, Uhles M, et al. The role of obesity in the increased prevalence of obstructive sleep apnea syndrome in patients with polycystic ovarian syndrome. Sleep Med. 2002;3:401–4.

    Article  PubMed  Google Scholar 

  67. Chatterjee B, Suri J, Suri JC, et al. Impact of sleep-disordered breathing on metabolic dysfunctions in patients with polycystic ovary syndrome. Sleep Med. 2014;15:1547–53.

    Article  PubMed  Google Scholar 

  68. Nandalike K, Agarwal C, Strauss T, et al. Sleep and cardiometabolic function in obese adolescent girls with polycystic ovary syndrome. Sleep Med. 2012;13:1307–12.

    Article  PubMed  PubMed Central  Google Scholar 

  69. Kahal H, Kyrou I, Tahrani A, Randeva H. Obstructive sleep apnoea and polycystic ovary syndrome: a comprehensive review of clinical interactions and underlying pathophysiology. Clin Endocrinol (Oxf). 2017;87:313–9.

    Article  CAS  PubMed  Google Scholar 

  70. Heinzer R, Vat S, Marques-Vidal P, et al. Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study. Lancet. Respir Med. 2015;3:310–8.

    CAS  Google Scholar 

  71. Tasali E, Chapotot F, Leproult R, et al. Treatment of obstructive sleep apnea improves cardiometabolic function in young obese women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2011;96:365–74.

    Article  CAS  PubMed  Google Scholar 

  72. Tasali E, Van Cauter E, Hoffman L, et al. Impact of obstructive sleep apnea on insulin resistance and glucose tolerance in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2008;93:3878–84.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Mokhlesi B, Scoccia B, Mazzone T, et al. Risk of obstructive sleep apnea in obese and nonobese women with polycystic ovary syndrome and healthy reproductively normal women. Fertil Steril. 2012;97:786–91.

    Article  PubMed  PubMed Central  Google Scholar 

  74. Yang HP, Kang JH, Su HY, et al. Apnea-hypopnea index in nonobese women with polycystic ovary syndrome. Int J Gynaecol Obstet. 2009;105:226–9.

    Article  PubMed  Google Scholar 

  75. Lin TY, Lin PY, Su TP, et al. Risk of developing obstructive sleep apnea among women with polycystic ovarian syndrome: a nationwide longitudinal follow-up study. Sleep Med. 2017;36:165–9.

    Article  PubMed  Google Scholar 

  76. Analysis of the proportion and clinical characteristics of obstructive sleep apnea in women with polycystic ovary syndrome. Sleep Breath. 2022;26:497–503.

    Google Scholar 

  77. Hoppin AG, Katz ES, Kaplan LM, et al. Case records of the Massachusetts General Hospital. Case 31–2006. A 15-year-old girl with severe obesity. N Engl J Med. 2006;355:1593–602.

    Article  CAS  PubMed  Google Scholar 

  78. Ismailogullari S, Ferahbas A, Aksu M, et al. Effects of isotretinoin treatment on sleep in patients with severe acne: a pilot study. J Eur Acad Dermatol Venereol. 2012;26:778–81.

    Article  CAS  PubMed  Google Scholar 

  79. Haynes D, Topham C, Greiling T. Acne keloidalis nuchae and obstructive sleep apnoea: a retrospective case series. Clin Exp Dermatol. 2019;44:e214–5.

    Article  CAS  PubMed  Google Scholar 

  80. Kelly AP. Pseudofolliculitis barbae and acne keloidalis nuchae. Dermatol Clin. 2003;21:645–53.

    Article  PubMed  Google Scholar 

  81. Verma SB, Wollina U. Acne keloidalis nuchae: another cutaneous symptom of metabolic syndrome, truncal obesity, and impending/overt diabetes mellitus? Am J Clin Dermatol. 2010;11:433–6.

    Article  PubMed  Google Scholar 

  82. Buyuktas D, Arslan E, Celik O, Tasan E, Demirkesen C, Gundogdu S. Elephantiasis nostras verrucosa on the abdomen of a Turkish female patient caused by morbid obesity. Dermatol Online J. 2010;16:14.

    Article  CAS  PubMed  Google Scholar 

  83. Shanmugam VK, Tsagaris KC, Attinger CE. Leg ulcers associated with Klinefelter's syndrome: a case report and review of the literature. Int Wound J. 2012;9:104–7.

    Article  PubMed  Google Scholar 

  84. Hegele RA, Al-Attar SA, Rutt BK. Obstructive sleep apnea in 2 women with familial partial lipodystrophy due to a heterozygous LMNA R482Q mutation. CMAJ. 2007;177:743–5.

    Article  PubMed  PubMed Central  Google Scholar 

  85. Carr A, Cooper DA. Adverse effects of antiretroviral therapy. Lancet. 2000;356(9239):1423–30.

    Article  CAS  PubMed  Google Scholar 

  86. Epstein LJ, Strollo PJ Jr, Donegan RB, Delmar J, Hendrix C, Westbrook PR. Obstructive sleep apnea in patients with human immunodeficiency virus (HIV) disease. Sleep. 1995;18:368–76.

    Article  CAS  PubMed  Google Scholar 

  87. Abdeen Y, Al-Halawani M, Kaako A, Hao IFY, Dazley J, Katpally R, Klukowicz A, Miller R, Slim J. Effect of the duration of protease inhibitor therapy in HIV-infected individuals on the severity of obstructive sleep apnea. J Res Med Sci. 2019;24:65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Harsch IA, Bergmann T, Koebnick C, Wiedmann R, Ruderich F, Hahn EG, et al. Adiponectin, resistin and subclinical inflammation—the metabolic burden in Launois Bensaude Syndrome, a rare form of obesity. J Physiol Pharmacol. 2007;58(Suppl 1):65–76.

    PubMed  Google Scholar 

  89. Hanson RD, Olsen KD, Rogers RS III. Upper aerodigestive tract manifestations of cicatricial pemphigoid. Ann Otol Rhinol Laryngol. 1988;97:493–9.

    Article  CAS  PubMed  Google Scholar 

  90. Hubbard M, Masters IB, Williams GR, et al. Severe obstructive sleep apnea secondary to pressure garments used in the treatment of hypertrophic burn scars. Eur Respir J. 2000;16:1205–7.

    Article  CAS  PubMed  Google Scholar 

  91. Gozal D, Ham SA, Mokhlesi B. Sleep apnea and cancer: analysis of a nationwide population sample. Sleep. 2016;39:1493–500.

    Article  PubMed  PubMed Central  Google Scholar 

  92. Gozal D, Farré R, Nieto FJ. Putative links between sleep apnea and cancer from hypotheses to evolving evidence. Chest. 2015;148:1140–7.

    Article  PubMed  PubMed Central  Google Scholar 

  93. Martínez-García MÁ, Campos-Rodriguez F, Barbé F. Cancer and OSA: current evidence from human studies. Chest. 2016;150:451–63.

    Article  PubMed  Google Scholar 

  94. Martínez-García MA, Martorell-Calatayud A, Nagore E, et al. Association between sleep disordered breathing and aggressiveness markers of malignant cutaneous melanoma. Eur Respir J. 2014;43:1661–8.

    Article  PubMed  Google Scholar 

  95. Almendros I, Montserrat JM, Torres M, et al. Intermittent hypoxia increases melanoma metastasis to the lung in a mouse model of sleep apnea. Respir Physiol Neurobiol. 2013;186:303–7.

    Article  CAS  PubMed  Google Scholar 

  96. Santamaria-Martos F, Benítez I, Girón C, Barbé F, Martínez-García MA, Hernández L, et al. Biomarkers of carcinogenesis and tumour growth in patients with cutaneous melanoma and obstructive sleep apnoea. Eur Respir J. 2018;51:1701885.

    Article  PubMed  Google Scholar 

  97. Almendros I, Martínez-García M, Campos-Rodríguez F, Riveiro-Falkenbach E, Rodríguez-Peralto JL, Nagore E, et al. Intermittent hypoxia is associated with high hypoxia inducible factor-1α but not high vascular endothelial growth factor cell expression in tumors of cutaneous melanoma patients. Front Neurol. 2018;9:272.

    Article  PubMed  PubMed Central  Google Scholar 

  98. Martinez-Garcia MA, Campos-Rodriguez F, Nagore E, Martorell A, Rodriguez-Peralto JL, Riveiro-Falkenbach E, et al. Sleep-disordered breathing is independently associated with increased aggressiveness of cutaneous melanoma: a multicenter observational study in 443 patients. Chest. 2018;154:1348–58.

    Article  PubMed  Google Scholar 

  99. Martinez-Garcia MA, Campos-Rodriguez F, Almendros I, et al. Relationship between sleep apnea and cancer. Arch Bronconeumol. 2015;51:456–61.

    Article  PubMed  Google Scholar 

  100. Tan NKW, Yap DWT, Tan BKJ, et al. The association of obstructive sleep apnea with melanoma incidence and mortality: a meta-analysis of 5,276,451 patients. Sleep Med. 2021;88:213–20.

    Article  PubMed  Google Scholar 

  101. Almendros I, Martínez-García MA, Campos-Rodríguez F, et al. Intermittent hypoxia is associated with high hypoxia inducible factor-1a but not high vascular endothelial growth factor cell expression in tumors of cutaneous melanoma patients. Front Neurol. 2018:9.

    Google Scholar 

  102. Hunyor I, Cook KM. Models of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancer. Am J Physiol Regul Integr Comp Physiol. 2018;315(R669):r87.

    Google Scholar 

  103. Li H, Chen J, Wang X, et al. Nodal induced by hypoxia exposure contributes todacarbazine resistance and the maintenance of stemness in melanoma cancer stem-like cells. Oncol Rep. 2018;39:2855–64.

    CAS  PubMed  Google Scholar 

  104. Sun X, Lv X, Yan Y, et al. Hypoxia-mediated cancer stem cell resistance and targeted therapy. Biomed Pharmacother. 2020;130:110623.

    Article  CAS  PubMed  Google Scholar 

  105. Lin Y, Xu J, Lan H. Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications. J Hematol Oncol. 2019;12:76.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Cole SW, Sood AK. Molecular pathways: beta-adrenergic signaling in cancer. Clin Cancer Res. 2012;18:1201–6.

    Article  CAS  PubMed  Google Scholar 

  107. Moretti S, Massi D, Farini V, et al. b-adrenoceptors are upregulated in humanmelanoma and their activation releases pro-tumorigenic cytokines and metalloproteases in melanoma cell lines. Lab Invest. 2013;93:279–90.

    Article  CAS  PubMed  Google Scholar 

  108. Dal Monte M, Calvani M, Cammalleri M, et al. b-Adrenoceptors as drug targets in melanoma: novel preclinical evidence for a role of b (3) -adrenoceptors. Br J Pharmacol. 2019;176:2496–508.

    Article  CAS  PubMed  Google Scholar 

  109. Baik I, Lee S, Thomas RJ, Shin C. Obstructive sleep apnea, low transferrin saturation levels, and male-pattern baldness. Int J Dermatol. 2019;58:67–74.

    Article  PubMed  Google Scholar 

  110. Reintgen C, Leavitt A, Pace E, Molas-Pierson J, Mast BA. Risk factor analysis for mastectomy skin flap necrosis. implications for intraoperative vascular analysis. Ann Plast Surg. 2016;76(Suppl 4):S336–9.

    Article  CAS  PubMed  Google Scholar 

  111. Pépin JL, Leger P, Veale D, Langevin B, Robert D, Lévy P. Side effects of nasal continuous positive airway pressure in sleep apnea syndrome. Study of 193 patients in two French sleep centers. Chest. 1995;107:375–81.

    Article  PubMed  Google Scholar 

  112. Pepin JL, Leger P, Veale D, et al. Side effects of nasal continuous positive airway pressure in sleep apnea syndrome. Study of 193 patients in two French sleep centers. Chest. 1995;107:375–81.

    Article  CAS  PubMed  Google Scholar 

  113. Reynaerts A, Bruze M, Erikstam U, et al. Allergic contact dermatitis from a medical device, followed by depigmentation. Contact Dermatitis. 1998;39:204–5.

    Article  CAS  PubMed  Google Scholar 

  114. Elkin PL, Mullin S, Sakilay S. Rosacea patients are at higher risk for obstructive sleep apnea: automated retrospective research. Stud Health Technol Inform. 2020;270:1381–2.

    PubMed  PubMed Central  Google Scholar 

  115. Logger JGM, Peppelman M, Vugt RV, Driessen RJB. Rosacea and use of continuous positive airway pressure mask for obstructive sleep apnea syndrome: report of five cases. Ann Dermatol. 2020;32:3.

    Article  Google Scholar 

  116. Matin A, Bliwise DL, Wellman JJ, Ewing HA, Rasmuson P. Resolution of dyshidrotic dermatitis of the hand after treatment with continuous positive airway pressure for obstructive sleep apnea. South Med J. 2002;95:253–4.

    Article  PubMed  Google Scholar 

  117. Nino G, Singareddy R. Severe onychophagia and finger mutilation associated with obstructive sleep apnea. J Clin Sleep Med. 2013;9:379–81.

    Article  PubMed  PubMed Central  Google Scholar 

  118. Arnardottir ES, Thorleifsdottir B, Svanborg E, et al. Sleep-related sweating in obstructive sleep apnoea: association with sleep stages and blood pressure. J Sleep Res. 2010;19:122–30.

    Article  PubMed  Google Scholar 

  119. Schlaud M, Urschitz MS, Urschitz-Duprat PM, et al. The German study on sleep-disordered breathing in primary school children: epidemiological approach, representativeness of study sample, and preliminary screening results. Paediatr Perinat Epidemiol. 2004;18:431–40.

    Article  PubMed  Google Scholar 

  120. Eitner S, Urschitz MS, Guenther A, et al. Sleep problems and daytime somnolence in a German population-based sample of snoring school-aged children. J Sleep Res. 2007;16:96–101.

    Article  PubMed  Google Scholar 

  121. Arnardottir ES, Janson C, Bjornsdottir E, et al. Nocturnal sweating–a common symptom of obstructive sleep apnoea: The Icelandic sleep apnoea cohort. BMJ Open. 2013;3:e002795.

    Article  PubMed  PubMed Central  Google Scholar 

  122. Gabryelska A, Sochal M, Wasik B, Bialasiewicz P. Patients with obstructive sleep apnea are over four times more likely to suffer from psoriasis than the general population. J Clin Sleep Med. 2018;14:153.

    Article  PubMed  PubMed Central  Google Scholar 

  123. Martinez-Garcia MA, Campos-Rodriguez F, Almendros I, Garcia-Rio F, Sanchez-de-la-Torre M, Farre R, et al. Cancer and sleep apnea: cutaneous melanoma as a case study. Am J Respir Crit Care Med. 2019;200:1345–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology, University Clinic of Navarra, Madrid, Spain

    Pedro Redondo

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  1. Pedro Redondo
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Correspondence to Pedro Redondo .

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  1. Clinica Universidad de Navarra, Pamplona, Spain

    Peter M. Baptista

  2. Hospital Constitución, ISSSTE, Monterrey, Nuevo León, Mexico

    Rodolfo Lugo Saldaña

  3. Sede Quinta de Mutis, Universidad del Rosario, Bogotá, Colombia

    Steve Amado

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Redondo, P. (2023). Dermatologic Changes Related to Patients with Obstructive Sleep Apnea. In: Baptista, P.M., Lugo Saldaña, R., Amado, S. (eds) Obstructive Sleep Apnea. Springer, Cham. https://doi.org/10.1007/978-3-031-35225-6_26

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