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Exploring Endophytes for In Vitro Synthesis of Bioactive Compounds in Medicinal and Aromatic Plants

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Biosynthesis of Bioactive Compounds in Medicinal and Aromatic Plants

Part of the book series: Food Bioactive Ingredients ((FBC))

Abstract

Symbiosis with microorganisms is an influential pathway in plant evolution, and many related components have yet to be discovered. Medicinal and aromatic plants are favoured by a wide range of researchers as natural sources for the development of pharmaceutical and aromatic products for humans. Endophytes are the “second genome” of plants and play an essential role in plant growth and development. Therefore, the analysis of molecular mechanisms of symbiosis can help shed light on the interplay between plants and endosymbionts and thus provide a basis for the application of plant microbial resources. In this chapter, we review the interactions between plants and microorganisms and the effects of endophytes on plant growth and the synthesis and accumulation of secondary metabolites. In addition, the research hotspots and application progress of plant endophytes are presented as a reference for understanding the regulatory role of plant microorganisms and to provide future research directions.

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References

  • Abdelshafy Mohamad OA, Ma JB, Liu YH, Zhang D, Hua S, Bhute S, Hedlund BP, Li WJ, Li L (2020) Beneficial endophytic bacterial populations associated with medicinal plant Thymus vulgaris alleviate salt stress and confer resistance to Fusarium oxysporum. Front Plant Sci 11:47

    Article  PubMed  PubMed Central  Google Scholar 

  • Anjum N, Chandra R (2019) Endophytic bacteria of Catharanthus roseus as an alternative source of vindoline and application of response surface methodology to enhance its production. Arch Biol Sci 71(1):27–38

    Article  Google Scholar 

  • Bai B, Liu W, Qiu X, Zhang J, Zhang J, Bai Y (2022) The root microbiome: community assembly and its contributions to plant fitness. J Integr Plant Biol 64(2):230–243

    PubMed  Google Scholar 

  • Bao T, Wang B, Li J, Dilcher D (2019) Pollination of cretaceous flowers. Proc Natl Acad Sci U S A 116(49):24707–24711

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Beerling DJ, Butterfield NJ (2012) Plants and animals as geobiological agents. In: Knoll AH, Canfield DE, Konhauser KO (eds) Fundamentals of geobiology. Blackwell Publishing Ltd, Oxford, pp 188–204

    Chapter  Google Scholar 

  • Beilsmith K, Thoen MPM, Brachi B, Gloss AD, Khan MH, Bergelson J (2019) Genome-wide association studies on the phyllosphere microbiome: embracing complexity in host-microbe interactions. Plant J 97(1):164–181

    Article  CAS  PubMed  Google Scholar 

  • Berendsen RL, Pieterse CM, Bakker PA (2012) The rhizosphere microbiome and plant health. Trends Plant Sci 17(8):478–486

    Article  CAS  PubMed  Google Scholar 

  • Bergelson J, Brachi B, Roux F, Vailleau F (2021) Assessing the potential to harness the microbiome through plant genetics. Curr Opin Biotechnol 70:167–173

    Article  CAS  PubMed  Google Scholar 

  • Cao YM, Tao JH, Jiang S, Zheng JB (2010) Biodiversity and ecological distribution of endophytic fungi in Atractylodes lanceolata. J Nanjing Univ Tradit Chin Med 26(2):137–139

    Google Scholar 

  • Chapin FS, Matson PA, Vitousek PM (2011) Principles of terrestrial ecosystem ecology, vol 48, 2nd edn. Springer, New York, pp 151–152

    Book  Google Scholar 

  • Chen HM (2020) Deciphering Salvia miltiorrhiza associated microbiome and regulating mechanism of tanshinone biosynthesis by their dominant species. Northwest A&F Univ 2:1–15

    Google Scholar 

  • Chen XL, Sun MC, Chong SL, Si JP, Wu LS (2022) Transcriptomic and metabolomic approaches deepen our knowledge of plant-endophyte interactions. Front Plant Sci 12:700200

    Article  PubMed  PubMed Central  Google Scholar 

  • Cheng YT, Zhang L, He SY (2019) Plant-microbe interactions facing environmental challenge. Cell Host Microbe 26(2):183–192

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Compant S, Samad A, Faist H, Sessitsch A (2019) A review on the plant microbiome: ecology, functions, and emerging trends in microbial application. J Adv Res 19:29–37

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cordovez V, Dini-Andreote F, Carrión VJ, Raaijmakers JM (2019) Ecology and evolution of plant microbiomes. Annu Rev Microbiol 73:69–88

    Article  CAS  PubMed  Google Scholar 

  • Cui JL, Vijayakumar V, Zhang G (2018) Partitioning of fungal endophyte assemblages in root-parasitic plant Cynomorium songaricum and its host Nitraria tangutorum. Front Microbiol 9:666

    Article  PubMed  PubMed Central  Google Scholar 

  • De Vries FT, Griffiths RI, Knight CG, Nicolitch O, Williams A (2020) Harnessing rhizosphere microbiomes for drought-resilient crop production. Science 368(6488):270–274

    Article  PubMed  Google Scholar 

  • De-Medeiros-Azevedo T, Aburjaile FF, Ferreira-Neto JRC, Pandolfi V, Benko-Iseppon AM (2021) The endophytome (plant-associated microbiome): methodological approaches, biological aspects, and biotech applications. World J Microbiol Biotechnol 37(12):206

    Article  PubMed  Google Scholar 

  • De-Pádua-Lúcio K, Rabelo ACS, Araújo CM, Brandão GC, de Souza GHB, da Silva RG, de Souza DMS, Talvani A, Bezerra FS, Cruz-Calsavara AJ, Costa DC (2018) Anti-inflammatory and antioxidant properties of black mulberry (Morus nigra L.) in a model of LPS-induced sepsis. Oxidative Med Cell Longev 2018:5048031

    Article  Google Scholar 

  • Dubey A, Malla MA, Kumar A, Dayanandan S, Khan ML (2020) Plants endophytes: unveiling hidden agenda for bioprospecting toward sustainable agriculture. Crit Rev Biotechnol 40(8):1210–1231

    Article  CAS  PubMed  Google Scholar 

  • Gao GF, Chu HY (2020) Techniques and methods of microbiomics and their applications. Chin J Plant Ecol 44(4):395–408

    Article  Google Scholar 

  • Gao M, Xiong C, Gao C, Tsui CKM, Wang MM, Zhou X, Zhang AM, Cai L (2021) Disease-induced changes in plant microbiome assembly and functional adaptation. Microbiome 9(1):187

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gopal M, Gupta A (2016) Microbiome selection could spur next-generation plant breeding strategies. Front Microbiol 7:1971

    Article  PubMed  PubMed Central  Google Scholar 

  • Harrison JG, Griffin EA (2020) The diversity and distribution of endophytes across biomes, plant phylogeny and host tissues: how far have we come and where do we go from here? Environ Microbiol 22(6):2107–2123

    Article  PubMed  PubMed Central  Google Scholar 

  • He W, Chung HY (2020) Exploring core functional microbiota related with flavor compounds involved in the fermentation of a natural fermented plain sufu (Chinese fermented soybean curd). Food Microbiol 90:103408

    Article  CAS  PubMed  Google Scholar 

  • He DM, Wang H, Chen JL, Lai CJS, Yan ZY, Huang LQ (2020) Microecology and geoherbalism of traditional Chinese medicine. China J Chin Mater Medica 45(2):290–302

    Google Scholar 

  • Huang W, Long C, Lam E (2018) Roles of plant-associated microbiota in traditional herbal medicine. Trends Plant Sci 23(7):559–562

    Article  CAS  PubMed  Google Scholar 

  • Huang W, Sun D, Wang R, An Y (2021) Integration of transcriptomics and metabolomics reveals the responses of sugar beet to continuous cropping obstacle. Front Plant Sci 12:711333

    Article  PubMed  PubMed Central  Google Scholar 

  • Huong NTM, Hoai PTT, Thao PTH, Huong TT, Chinh VD (2022) Growth stimulation, phosphate resolution, and resistance to fungal pathogens of some endogenous fungal strains in the rhizospheres of medicinal plants in Vietnam. Molecules 27(16):5051

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jung JH, Barbosa AD, Hutin S, Kumita JR, Gao M, Derwort D, Silva CS, Lai X, Pierre E, Geng F, Kim SB, Baek S, Zubieta C, Jaeger KE, Wigge PA (2020) A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis. Nature 585(7824):256–260

    Article  CAS  PubMed  Google Scholar 

  • Kang YC, Jin R, Wen TC, He J, Lei BX (2011) Recent research advances on endophytic fungi producing taxol. Mycosystema 30(2):168–179

    CAS  Google Scholar 

  • Krasteva G, Georgiev V, Pavlov A (2020) Recent applications of plant cell culture technology in cosmetics and foods. Eng Life Sci 21(3–4):68–76

    PubMed  PubMed Central  Google Scholar 

  • Kumar A, Patil D, Rajamohanan PR, Ahmad A (2013) Isolation, purification and characterization of vinblastine and vincristine from endophytic fungus Fusarium oxysporum isolated from Catharanthus roseus. PLoS One 8(9):e71805

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kumar A, Vandana A, Singh M, Singh PP, Singh SK, Singh PK, Pandey KD (2016) Isolation of plant growth promoting rhizobacteria and their impact on growth and curcumin content in Curcuma longa L. Biocatal Agric Biotechnol 8:1–7

    Article  Google Scholar 

  • Lemanceau P, Blouin M, Muller D, Moënne-Loccoz Y (2017) Let the core microbiota be functional. Trends Plant Sci 22(7):583–595

    Article  CAS  PubMed  Google Scholar 

  • Li Q, Wang YQ, Peng T, Li SN, Yao YY (2020) Research progress of microbial fertilizer and its application in the production of traditional Chinese medicine. Agric Technol 40(19):1–4

    Google Scholar 

  • Li D, Zheng X, Lin L, An Q, Jiao Y, Li Q, Li Z, Hong Y, Zhang K, Xie C, Yin J, Zhang H, Wang B, Hu Y, Zhu Z (2022) Remediation of soils co-contaminated with cadmium and dichlorodiphenyltrichloroethanes by king grass associated with Piriformospora indica: insights into the regulation of root excretion and reshaping of rhizosphere microbial community structure. J Hazard Mater 422:126936

    Article  CAS  PubMed  Google Scholar 

  • Li Z, Xiong K, Wen W, Li L, Xu D (2023) Functional endophytes regulating plant secondary metabolism: current status, prospects and applications. Int J Mol Sci 24(2):1153

    Google Scholar 

  • Liu C, Niu G, Zhang H, Sun Y, Sun S, Yu F, Lu S, Yang Y, Li J, Hong Z (2018) Trimming of N-Glycans by the Golgi-localized α-1,2-mannosidases, MNS1 and MNS2, is crucial for maintaining RSW2 protein abundance during salt stress in Arabidopsis. Mol Plant 11(5):678–690

    Article  CAS  PubMed  Google Scholar 

  • Liu TH, Zhang XM, Tian SZ, Chen LG, Yuan JL (2020) Bioinformatics analysis of endophytic bacteria related to berberine in the Chinese medicinal plant Coptis teeta wall. 3 Biotech 10(3):96

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu H, Li Y, Hu Y, Yang Y, Zhang W, He M, Li X, Zhang C, Kong F, Liu X, Hou X (2021) EDS1-interacting J protein 1 is an essential negative regulator of plant innate immunity in Arabidopsis. Plant Cell 33(1):153–171

    PubMed  Google Scholar 

  • Liu H, Able AJ, Able JA (2022a) Priming crops for the future: rewiring stress memory. Trends Plant Sci 27(7):699–716

    Article  CAS  PubMed  Google Scholar 

  • Liu Z, Hou S, Rodrigues O, Wang P, Luo D, Munemasa S, Lei J, Liu J, Ortiz-Morea FA, Wang X, Nomura K, Yin C, Wang H, Zhang W, Zhu-Salzman K, He SY, He P, Shan L (2022b) Phytocytokine signalling reopens stomata in plant immunity and water loss. Nature 605(7909):332–339

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lou DD, Wang CK, Jin Y (2017) Plant water-regulation strategies: isohydric versus anisohydric behavior. Chin J Plant Ecol 41(9):1020–1032

    Article  Google Scholar 

  • Lv QY, Han ML, Gao YQ, Zhang CY, Wang YL, Chao ZF, Zhong LY, Chao DY (2022) Sec24C mediates a Golgi-independent trafficking pathway that is required for tonoplast localisation of ABCC1 and ABCC2. New Phytol 235(4):1486–1500

    Article  CAS  PubMed  Google Scholar 

  • Ma J, Chen Y, Wang K, Huang Y, Wang H (2021) Re-utilization of Chinese medicinal herbal residues improved soil fertility and maintained maize yield under chemical fertilizer reduction. Chemosphere 283:131262

    Article  CAS  PubMed  Google Scholar 

  • Maher MF, Nasti RA, Vollbrecht M, Starker CG, Clark MD, Voytas DF (2020) Plant gene editing through de novo induction of meristems. Nat Biotechnol 38(1):84–89

    Article  CAS  PubMed  Google Scholar 

  • Mahmoudi TR, Yu JM, Liu S, Pierson LS, Pierson EA (2019) Drought-stress tolerance in wheat seedlings conferred by Phenazine-producing Rhizobacteria. Front Microbiol 10:1590

    Article  PubMed  PubMed Central  Google Scholar 

  • Martin VJ, Pitera DJ, Withers ST, Newman JD, Keasling JD (2003) Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat Biotechnol 21(7):796–802

    Article  CAS  PubMed  Google Scholar 

  • Masmoudi F, Abdelmalek N, Tounsi S, Dunlap CA, Trigui M (2019) Abiotic stress resistance, plant growth promotion and antifungal potential of halotolerant bacteria from a Tunisian solar saltern. Microbiol Res 229:126331

    Article  CAS  PubMed  Google Scholar 

  • Müller DB, Vogel C, Bai Y, Vorholt JA (2016) The plant microbiota: systems-level insights and perspectives. Annu Rev Genet 50:211–234

    Article  PubMed  Google Scholar 

  • Namdeo A, Patil S, Fulzele DP (2002) Influence of fungal elicitors on production of ajmalicine by cell cultures of Catharanthus roseus. Biotechnol Prog 18(1):159–162

    Article  CAS  PubMed  Google Scholar 

  • Nogales A, Nobre T, Valadas V, Ragonezi C, Döring M, Polidoros A, Arnholdt-Schmitt B (2016) Can functional hologenomics aid tackling current challenges in plant breeding? Brief Funct Genomics 15(4):288–297

    Article  PubMed  Google Scholar 

  • Palem PP, Kuriakose GC, Jayabaskaran C (2015) An Endophytic fungus, Talaromyces radicus, isolated from Catharanthus roseus, produces vincristine and vinblastine, which induce apoptotic cell death. PLoS One 10(12):e0144476

    Article  PubMed  PubMed Central  Google Scholar 

  • Park CH, Park YE, Yeo HJ, Yoon JS, Park SY, Kim JK, Park SU (2021) Comparative analysis of secondary metabolites and metabolic profiling between diploid and tetraploid Morus alba L. J Agric Food Chem 69(4):1300–1307

    Article  CAS  PubMed  Google Scholar 

  • Pérez-Jaramillo JE, Mendes R, Raaijmakers JM (2016) Impact of plant domestication on rhizosphere microbiome assembly and functions. Plant Mol Biol 90(6):635–644

    Article  PubMed  Google Scholar 

  • Qi ZX, Li JL, He QZH, Lu L, Li RL (2022) Research progress on genome sequencing and biosynthesis pathway of bioactive substances in medicinal plants. Chin J Cell Biol 44(2):381–390

    Google Scholar 

  • Rimsha K, Syeda TQN, Nighat F, Syed AM (2019) Study of antidiabetic activities of endophytic fungi isolated from plants. Pure Appl Biol 8(2):1287–1295

    Google Scholar 

  • Sasse J, Martinoia E, Northen T (2018) Feed your friends: do plant exudates shape the root microbiome? Trends Plant Sci 23(1):25–41

    Article  CAS  PubMed  Google Scholar 

  • Schiering C, Wincent E, Metidji A, Iseppon A, Li Y, Potocnik AJ, Omenetti S, Henderson CJ, Wolf CR, Nebert DW, Stockinger B (2017) Feedback control of AHR signalling regulates intestinal immunity. Nature 542(7640):242–245

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schippmann U, Leaman DJ, Cunningham AB (2002) Impact of cultivation and gathering of medicinal plants on biodiversity: global trends and issues. Inter-Department Working Group on Biology Diversity for Food and Agriculture, FAO, Rome. Available at: http://www.fao.org/3/aa010e/AA010E00.pdf

  • Schlaeppi K, Bulgarelli D (2015) The plant microbiome at work. Mol Plant-Microbe Interact 28(3):212–217

    Article  CAS  PubMed  Google Scholar 

  • Segata N, Baldini F, Pompon J, Garrett WS, Truong DT, Dabiré RK, Diabaté A, Levashina EA, Catteruccia F (2016) The reproductive tracts of two malaria vectors are populated by a core microbiome and by gender- and swarm-enriched microbial biomarkers. Sci Rep 6:24207

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shade A, Handelsman J (2012) Beyond the Venn diagram: the hunt for a core microbiome. Environ Microbiol 14(1):4–12

    Article  CAS  PubMed  Google Scholar 

  • Shukla ST, Kulkarni VH, Habbu PV, Jagadeesh KS, Smita B (2012) Hepatoprotective and antioxidant activities of crude fractions of endophytic fungi of Ocimum sanctum Linn. in rats. Orient Pharm Exp Med 12(2):81–91

    Article  Google Scholar 

  • Song LY, Gu JM, Liu XB (2009) The status of development and utilization of Chinese medicine resources and counter measures on sustainable development. Chin Arch Tradit Chin Med 27(1):86–88

    Google Scholar 

  • Song H, Liu J, Song P, Feng L, Wu CZ, Hong W (2020) Effects of inoculation with Endophytic fungi and Endophytic bacteria on growth and accumulation of secondary metabolites in Tripterygium wilfordii. J Trop Subtrop Bot 28(4):347–355

    Google Scholar 

  • Stierle A, Strobel G, Stierle D (1993) Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Science 260(5105):214–216

    Article  CAS  PubMed  Google Scholar 

  • Sun X, Xu Z, Xie J, Hesselberg-Thomsen V, Tan T, Zheng D, Strube ML, Dragoš A, Shen Q, Zhang R, Kovács ÁT (2022) Bacillus velezensis stimulates resident rhizosphere Pseudomonas stutzeri for plant health through metabolic interactions. ISME J 16(3):774–787

    Article  CAS  PubMed  Google Scholar 

  • Takahashi F, Suzuki T, Osakabe Y, Betsuyaku S, Kondo Y, Dohmae N, Fukuda H, Yamaguchi-Shinozaki K, Shinozaki K (2018) A small peptide modulates stomatal control via abscisic acid in long-distance signalling. Nature 556(7700):235–238

    Article  CAS  PubMed  Google Scholar 

  • Tan Y, Jia R, Tao JH, Yang NY, Duan JA, Qian DW, Jiang S (2013) Regulation on biosynthesis of active constituents in medicinal plants by endophytic fungal elicitor. Chin Tradit Herb Drug 44(14):2004–2008

    CAS  Google Scholar 

  • Tan Y, Cui Y, Li H, Kuang A, Li X, Wei Y, Ji X (2017) Rhizospheric soil and root endogenous fungal diversity and composition in response to continuous Panax notoginseng cropping practices. Microbiol Res 194:10–19

    Article  PubMed  Google Scholar 

  • Thomas T, Moitinho-Silva L, Lurgi M, Björk JR, Easson C, Astudillo-García C, Olson JB, Erwin PM, López-Legentil S, Luter H, Chaves-Fonnegra A, Costa R, Schupp PJ, Steindler L, Erpenbeck D, Gilbert J, Knight R, Ackermann G, Victor-Lopez J, Taylor MW, Thacker RW, Montoya JM, Hentschel U, Webster NS (2016) Diversity, structure and convergent evolution of the global sponge microbiome. Nat Commun 7:11870

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Thomloudi EE, Tsalgatidou PC, Baira E, Papadimitriou K, Venieraki A, Katinakis P (2021) Genomic and metabolomic insights into secondary metabolites of the novel Bacillus halotolerans Hil4, an endophyte with promising antagonistic activity against gray mold and plant growth promoting potential. Microorganisms 9(12):2508

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Timilsina S, Potnis N, Newberry EA, Liyanapathiranage P, Iruegas-Bocardo F, White FF, Goss EM, Jones JB (2020) Xanthomonas diversity, virulence and plant-pathogen interactions. Nat Rev Microbiol 18(8):415–427

    Article  CAS  PubMed  Google Scholar 

  • Toju H, Peay KG, Yamamichi M, Narisawa K, Hiruma K, Naito K, Fukuda S, Ushio M, Nakaoka S, Onoda Y, Yoshida K, Schlaeppi K, Bai Y, Sugiura R, Ichihashi Y, Minamisawa K, Kiers ET (2018) Core microbiomes for sustainable agroecosystems. Nat Plants 4(5):247–257

    Article  PubMed  Google Scholar 

  • Trivedi P, Leach JE, Tringe SG, Sa T, Singh BK (2020) Plant-microbiome interactions: from community assembly to plant health. Nat Rev Microbiol 18(11):607–621

    Article  CAS  PubMed  Google Scholar 

  • Turner TR, James EK, Poole PS (2013) The plant microbiome. Genome Biol 14(6):209

    Article  PubMed  PubMed Central  Google Scholar 

  • Ulrich DEM, Sevanto S, Ryan M, Albright MBN, Johansen RB, Dunbar JM (2019) Plant-microbe interactions before drought influence plant physiological responses to subsequent severe drought. Sci Rep 9(1):249

    Article  PubMed  PubMed Central  Google Scholar 

  • Venturi V, Bez C (2021) A call to arms for cell-cell interactions between bacteria in the plant microbiome. Trends Plant Sci 26(11):1126–1132

    Article  CAS  PubMed  Google Scholar 

  • Wainwright M, Lederberg J (1992) History of microbiology // Schaechter M. Encyclopedia of microbiology. Academic, Lederberg, p 291b

    Google Scholar 

  • Walsh CM, Becker-Uncapher I, Carlson M, Fierer N (2021) Variable influences of soil and seed-associated bacterial communities on the assembly of seedling microbiomes. ISME J 15(9):2748–2762

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang HY, Kang CH, Wang S, Jiang DQ, Peng Z, Xu Y, Du YX, Zhang Y, Liu DH, Guo LP (2021) Research strategies for endophytes in medicinal plants based on high-throughput sequencing and traditional culture and isolation methods. China J Chin Mater Medica 46(8):1910

    Google Scholar 

  • Wei Z, Jousset A (2017) Plant breeding goes microbial. Trends Plant Sci 22(7):555–558

    Article  CAS  PubMed  Google Scholar 

  • Wu HM, Zhang SK, Jiao YY, Lin Y, Wu HM, Qin XJ, Liu YZ, Chen J, Lin WX (2021a) Effects of microbial fertilizer application on the quality and pharmacological activities of radix pseudostellariae under continuous monoculture regimes. Chin J Eco-Agric 29(8):1315–1326

    CAS  Google Scholar 

  • Wu W, Chen W, Liu S, Wu J, Zhu Y, Qin L, Zhu B (2021b) Beneficial relationships between Endophytic bacteria and medicinal plants. Front Plant Sci 12:646146

    Article  PubMed  PubMed Central  Google Scholar 

  • Xiang B, Zhou X, Qin D, Li C, Xi J (2021) Infrared assisted extraction of bioactive compounds from plant materials: current research and future prospect. Food Chem 371:131192

    Article  PubMed  Google Scholar 

  • Xie XG, Fu WQ, Zhang FM, Shi XM, Zeng YT, Li H, Zhang W, Dai CC (2017) The endophytic fungus Phomopsis liquidambari increases nodulation and N2 fixation in Arachis hypogaea by enhancing hydrogen peroxide and nitric oxide signalling. Microb Ecol 74(2):427–440

    Article  CAS  PubMed  Google Scholar 

  • Xie XG, Zhang FM, Wang XX, Li XG, Dai CC (2019) Phomopsis liquidambari colonization promotes continuous cropping peanut growth by improving the rhizosphere microenvironment, nutrient uptake and disease incidence. J Sci Food Agric 99(4):1898–1907

    Article  CAS  PubMed  Google Scholar 

  • Xiong C, Singh BK, He JZ, Han YL, Li PP, Wan LH, Meng GZ, Liu SY, Wang JT, Wu CF, Ge AH, Zhang LM (2021) Plant developmental stage drives the differentiation in ecological role of the maize microbiome. Microbiome 9(1):171

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xue JZ, Wang JS, Li BX, Huang P, Liu L (2022) Origin and early evolution of land plants and the effects on Earth’s environments. Earth Sci 47:3648–3664

    Google Scholar 

  • Yang XC, Hwa CM (2008) Genetic modification of plant architecture and variety improvement in rice. Heredity (Edinb) 101(5):396–404

    Article  CAS  PubMed  Google Scholar 

  • Yeo HJ, Park CH, Park YE, Hyeon H, Kim JK, Lee SY, Park SU (2021) Metabolic profiling and antioxidant activity during flower development in Agastache rugosa. Physiol Mol Biol Plants 27(3):445–455

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yin DD, Wang YL, Yang M, Yin DK, Wang GK, Xu F (2019) Analysis of Chuanxiong Rhizoma substrate on production of ligustrazine in endophytic Bacillus subtilis by ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry. J Sep Sci 42(19):3067–3076

    Article  CAS  PubMed  Google Scholar 

  • You H, Yang S, Zhang L, Hu X, Li O (2017) Promotion of phenolic compounds production in Salvia miltiorrhiza hairy roots by six strains of rhizosphere bacteria. Eng Life Sci 18(3):160–168

    Article  PubMed  PubMed Central  Google Scholar 

  • Zheng X, Wang Z, Zhu Y, Wang J, Liu B (2020) Effects of a microbial restoration substrate on plant growth and rhizosphere bacterial community in a continuous tomato cropping greenhouse. Sci Rep 10(1):13729

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (32260089, 31960074), Innovation and Entrepreneurship Education of Guizhou Ordinary Undergraduate Colleges (2022SCJZW10), Future Outstanding Teachers Training Program of Zunyi Medical University, Postgraduate Teaching Reform Project of Zunyi Medical University (ZYK105), Undergraduate Education and Teaching Reform Project of Zunyi Medical University (XJJG2022-22), Joint Bidding Project of Zunyi Science & Technology Department and Zunyi Medical University (No. ZSKHHZ[2020]91), Science and Technology Department Foundation of Guizhou Province of China (No. QKPTRC [2019]-027), and Science and Technology Plan Project of Honghuagang District, Zunyi City (No. ZHKHNZT(2020)04).

Contribution Statement

  • Zhaogao Li: Conceptualization, Writing, visualization, and investigation

  • Delin Xu: Writing, reviewing, and editing; supervision, project administration, and funding acquisition

Declaration of Competing Interests

The authors declare no potential conflicts of interest concerning the research, authorship, and/or publication of this article.

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Authors and Affiliations

  1. Department of Cell Biology, Zunyi Medical University, Zunyi, Guizhou, China

    Delin Xu & Zhaogao Li

  2. Department of Medical Instrumental Analysis, Zunyi Medical University, Zunyi, Guizhou, China

    Delin Xu

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  1. Delin Xu
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  1. Department of Biotechnology, Central University of South Bihar, Gaya, Bihar, India

    Nitish Kumar

  2. Department of Plant Breeding and Genetics, Bihar Agricultural University, Bhagalpur, Bihar, India

    Ravi S. Singh

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Xu, D., Li, Z. (2023). Exploring Endophytes for In Vitro Synthesis of Bioactive Compounds in Medicinal and Aromatic Plants. In: Kumar, N., S. Singh, R. (eds) Biosynthesis of Bioactive Compounds in Medicinal and Aromatic Plants. Food Bioactive Ingredients. Springer, Cham. https://doi.org/10.1007/978-3-031-35221-8_5

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