Abstract
Natural products have been a precious source of innumerable bioactive chemicals due to which many conventional therapies and remedies have been associated with them. Phytochemicals such as alkaloids, flavonoids, glycosides, terpenoids, and many more have contributed significantly to the drug discovery process. Many phytochemical formulations have aided in improving the health status of patients in clinical settings. However, some problems related to the effective delivery of natural constituents to their site of action still exist. These are mainly attributable to the challenging physicochemical and pharmacokinetic characteristics. To address these issues, a lot of research is being conducted that is based upon the interlinking of natural products with nanotechnology. Many studies have shown encouraging outcomes in terms of the targeted delivery of these phytochemicals to their intended sites for the desired therapeutic response using nanocarriers such as metallic nanoparticles, liposomes, and dendrimers, among others. Due to their better tolerability as compared to synthetic chemical entities, natural products particularly the phytochemicals are being explored for achieving delivery through active and passive targeting. This chapter provides an introduction to the formulation barriers of natural products and the recent advances in nanotechnology and formulation science in improving the overall drug targeting to the intended site of action.
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Ibrahim, A., Fatima, H., Babar, M.M. (2023). Targeted Delivery of Natural Products. In: Cruz, J.N. (eds) Drug Discovery and Design Using Natural Products. Springer, Cham. https://doi.org/10.1007/978-3-031-35205-8_12
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