Overview
- Editors:
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Jorddy Neves Cruz
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Adolpho Ducke Laboratory, Paraense Emilio Goeldi Museum, Belém, Brazil
- Addresses scientific advances that provide practical solutions to using natural products to develop new drugs
- Examines the initial processes for discovery of compounds and identification of these structures in vitro methods
- Discusses topics related to the genesis of research projects that use natural products to design new drugs
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Table of contents (20 chapters)
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Genesis of Research Projects That Use Natural Products to Design New Drugs
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- Sheikh Rezzak Ali, Shuby Kumari, Satyendra K. Prasad, Rupali S. Prasad, Saurabh K. Sinha, Anshul Shakya
Pages 3-21
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- Antony V. Samrot, M. Sathiya Sree, D. Rajalakshmi, L. Noel Richard Prakash, P. Prakash
Pages 23-36
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- Rania Hamdy, Alaa M. Altaie, Eman M. El-Labbad, Naglaa S. Ashmawy, Dilber Uzun Ozsahin, Mohamed I. Husseiny et al.
Pages 37-78
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- Gabrielly Baia Pinto, Adriane dos Reis Corrêa, Giovanna Nicole Costa da Silva, Jamile Silva da Costa, Pablo Luis Baia Figueiredo
Pages 79-101
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- Thadiyan Parambil Ijinu, Bernard Prabha, Palpu Pushpangadan, Varughese George
Pages 103-149
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Initial Processes for Identifying and Extracting Compounds: Isolation and Identifying These Structures
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Front Matter
Pages 151-151
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- Alicia Ludymilla Cardoso de Souza, Anderson do Rego Pires, Carlos André Ferreira Moraes, Chrystiaine Helena Campos de Matos, Kyouk Isabel Portilho dos Santos, Renan Campos e Silva et al.
Pages 153-176
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- K. Vidwathpriya, S. Sriranjani, P. K. Niharika, N. V. Anil Kumar
Pages 177-208
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- S. Nithya, Rohan R. Krishnan, Nachiketha R. Rao, Kamakshi Naik, N. Praveen, V. L. Vasantha
Pages 209-238
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Screening of Compounds Using Molecular Modeling Approaches: Optimization of Natural Compounds Using In Silico Methods
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Front Matter
Pages 239-239
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- Tathagata Adhikary, Piyali Basak
Pages 241-269
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Synthesis and Encapsulation of Compounds of Natural Origin
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Front Matter
Pages 271-271
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- Miriam Ruiz-Serrano, J. Carlos Menéndez
Pages 273-322
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- Marcelo Assis, Mariana Ottaiano Gonçalves, Camila Cristina de Foggi, Monize Burck, Sergiana dos Passos Ramos, Laura Ordonho Libero et al.
Pages 323-374
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Identification of Molecular Targets of Natural Molecules and Biological Potential
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Front Matter
Pages 375-375
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- Ahsan Ibrahim, Hunaiza Fatima, Mustafeez Mujtaba Babar
Pages 377-393
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- Nourhan G. Naga, Mona I. Shaaban
Pages 395-416
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About this book
Historically, natural products have great relevance for the development of new drugs. Natural molecules, in addition to directly providing new compounds with different therapeutic functions have provided scaffolds and a great diversity of structures that serve as inspiration for the design and discovery of new drugs. The great structural complexity and the significant number of natural compounds that can be obtained and their advantages also present some historical problems that need to be overcome. Issues such as difficulty in isolation, difficulty in synthesizing compounds found in nature in the laboratory, screening to evaluate the biological properties of these compounds, and structural optimization to enhance the pharmacological properties of biomolecules; are some of the main difficulties encountered in research with natural products and in the design/discovery of new medicines. Therefore, this book addresses the great scientific advances that provide practical solutions to usingnatural products to develop new drugs. We address topics related to the genesis of research projects that use natural products to design new drugs. We address the discovery of new species, initial processes for identification and extraction of compounds, isolation and identification of these structures, techniques, and advances in vitro and in vivo methods that support the discovery of new natural drugs, synthesis of new compounds from natural molecules, in silico optimization processes of potentially promising compounds.
Editors and Affiliations
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Adolpho Ducke Laboratory, Paraense Emilio Goeldi Museum, Belém, Brazil
Jorddy Neves Cruz
About the editor
Jorddy Neves Cruz develops his research projects in Universidade Federal do Pará and Museu Paraense Emílio Goeldi. His research focuses on (1) Medicinal Chemistry, with a particular emphasis on natural products and drug discovery/ design; (2) Extraction and characterization of compounds of natural origin (isolated compounds, essential oils, and fixed oils); (3) molecular modeling approaches and (4) evaluation of biological activities and pharmacological potential of natural compounds.
