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Effect of Mechanical Aortic Valves on Coronary Artery Flow in a Patient Suffering from Ischemic Heart Disease

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Computational Biomechanics for Medicine (MICCAI 2021)

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Abstract

Coronary artery disease is the most common cardiovascular condition and one of the leading causes of death worldwide. Coronary artery disease is caused by a narrowing or complete occlusion of the coronary artery lumen. Early diagnosis and correct assessment of the existing stenosis are essential. In our study, a pilot study in this regard, we present a method of non-invasive FFR estimation based on 3D numerical simulations of blood flow through coronary arteries in a 50-year-old man with coronary artery stenosis. Our study considered patient-specific coronary artery geometry. The study determined the effect of blood pressure gradient in flow across mechanical trileaflet (TRI) and bileaflet (BIL) and natural aortic valves on the fractional coronary flow reserve (FFR) value. The predicted value of the FFR ratio for the natural valve is 82% while the FFR value from coronarography is 83%. The predicted FFR values for BIL and TRI mechanical valves are 77% and 75%, respectively.

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Authors and Affiliations

  1. Institute of Mechanics and Printing, Warsaw University of Technology, Narbutta 85, 02-524, Warszawa, Poland

    Anna Nieroda, Krzysztof Jankowski & Marek Pawlikowski

Authors
  1. Anna Nieroda
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  2. Krzysztof Jankowski
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  3. Marek Pawlikowski
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Corresponding author

Correspondence to Marek Pawlikowski .

Editor information

Editors and Affiliations

  1. Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand

    Martyn P. Nash

  2. Intelligent Systems for Medicine Laboratory, Department of Mechanical Engineering, The University of Western Australia, Perth, WA, Australia

    Adam Wittek

  3. Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand

    Poul M. F. Nielsen

  4. Department of Mechanics, Materials and Biomedical Engineering, Wrocław University of Science and Technology, Wrocław, Poland

    Magdalena Kobielarz

  5. Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Rourkela, India

    Anju R. Babu

  6. Intelligent Systems for Medicine Laboratory, Department of Mechanical Engineering, The University of Western Australia, Perth, WA, Australia

    Karol Miller

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Nieroda, A., Jankowski, K., Pawlikowski, M. (2023). Effect of Mechanical Aortic Valves on Coronary Artery Flow in a Patient Suffering from Ischemic Heart Disease. In: Nash, M.P., Wittek, A., Nielsen, P.M.F., Kobielarz, M., Babu, A.R., Miller, K. (eds) Computational Biomechanics for Medicine. MICCAI 2021. Springer, Cham. https://doi.org/10.1007/978-3-031-34906-5_10

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  • DOI: https://doi.org/10.1007/978-3-031-34906-5_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-34905-8

  • Online ISBN: 978-3-031-34906-5

  • eBook Packages: MedicineMedicine (R0)

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