Skip to main content

How Innovations Can Impact on people’s Life: The Continuum of Research in Global Health

  • Chapter
  • First Online:
Global Health Essentials

Part of the book series: Sustainable Development Goals Series ((SDGS))

  • 791 Accesses

Abstract

Knowledge is at the heart of health research, and production of relevant evidence along the overall spectrum of research—from basic science for discovery to the development of new tools or strategies, and their optimal uptake—is essential to improve health globally. The intention of this chapter is to present how thinking along the research continuum provides a solid basis to identify where and how interactions and synergies can take place profitably towards a common goal, and avoid dispersion of means, energies and funding. Mapping institutions, programmes and teams involved in research for a given health condition and matching these to research needs and priorities at national and international levels is fundamental to improve the relevance, quality and efficiency of research. Capitalizing on greater recognition of the value of research for health and society, an end-to-end vision is proposed, encompassing the full continuum of research to gain evidence from multiple sources, for ultimately linking research, policy and practice.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    In TB research, for instance, a network of longitudinal studies of patients and households are being used to identify biomarkers that characterize the various clinically relevant stages of TB, together with studies on how to prevent transmission and disease development.

References

  1. Collins FS. COVID-19 lessons for research. Science. 2021;371(6534):1081. https://doi.org/10.1126/Science.abh3996.

    Article  CAS  PubMed  Google Scholar 

  2. WHO. Universal health coverage (UHC). 2022. https://www.who.int/news-room/fact-sheets/detail/universal-health-coverage-(Uhc).

  3. World Health Organization: The world health report 2013: research for universal health coverage. WHO, Geneva, 2013. https://www.who.int/whr/2013/report/en/.

  4. World Health Organization and Stop TB Partnership. An International Roadmap for Tuberculosis Research. Geneva, World Health Organization, 2011.

    Google Scholar 

  5. World Health Organization. A global action framework for TB research in support of the third pillar of WHO’s end TB strategy. Geneva, 2015. WHO/HTM/TB/2015.26.

  6. Medical Research Council on behalf of the UK Clinical Research Collaboration (UKCRC). UK clinical research collaboration health research classification system. 2018. http://hrcsonline.net/wp-content/uploads/2018/01/HRCS_Main_Handbook_v2_Feb2018.pdf

  7. Lienhardt C. Fundamental research is the key to eliminating TB. Nature. 2014;507:401.

    Article  CAS  PubMed  Google Scholar 

  8. Pocock SJ. Clinical trials: a practical approach. London: Wiley; 1983.

    Google Scholar 

  9. Smith PG, Morrow RH, Ross DA. Field trials of health interventions–a toolbox. 3rd ed. Oxford (UK): Oxford University Press; 2015. ISBN-10: 0198732864ISBN-13: 9780198732860.

    Book  Google Scholar 

  10. Zachariah R, Harries A, Ishikawa N, et al. Operational research in low-income countries: what, why, and how? Lancet Infect Dis. 2009;9:711–7.

    Article  PubMed  Google Scholar 

  11. Lobb R, Colditz GA. Implementation science and its application to population health. Ann Rev Public Health. 2013;34:235–51. https://doi.org/10.1146/annurev-publhealth-031912-114444. PMID:23297655.

    Article  Google Scholar 

  12. World Health Organization. Operational research for malaria control: tutor’s guide. WHO/HTM/RBM. Part II. Geneva, Switzerland: WHO; 2003. http://apps.who.int/malaria/docs/operational_research_tg.pdf.

    Google Scholar 

  13. Lienhardt C, Cobelens F. Operational research for TB control: the scope, the needs and the way forward. Int J Tuberc Lung Dis. 2011;15(1):6–13. PMID: 21276290.

    CAS  PubMed  Google Scholar 

  14. Zachariah R, et al. Is operational research delivering the goods? the journey to success in low-income countries. Lancet Infect Dis. 2012;12:415–21. https://doi.org/10.1016/S1473-3099(11)70309-7. PMID:22326018.

    Article  PubMed  Google Scholar 

  15. Hanney S, Gonzalez-Block M, Buxton M, Kogan M. Health research policy and systems. The utilisation of health research in policy-making: concepts, examples and methods of assessment. Health Res Policy Sys. 2003;1:2.

    Article  Google Scholar 

  16. Masood S, Kothari A, Regan S. The use of research in public health policy: a systematic review. Evidence Policy. 2020;16(1):7–43. https://bristoluniversitypressdigital.com/view/journals/evp/16/1/article-p7.xml

    Article  Google Scholar 

  17. Koplan JP, Bond TC, Merson MH, et al. Towards a common definition of global health. Lancet. 2009;373:1993–5.

    Article  PubMed  PubMed Central  Google Scholar 

  18. World Health Organization. World malaria report 2021. World Health Organization. 2021. https://apps.who.int/iris/handle/10665/350147. Licence: CC BY-NC-SA 3.0 IGO.

  19. WHO. First-ever malaria vaccine recommendation now published in a position paper and in the WHO guidelines for malaria. 2022. https://www.who.int/news/item/04-03-2022-first-ever-malaria-vaccine-recommendation-now-published-in-a-position-paper-and-in-the-who-guidelines-for-malaria.

  20. RTS,S Clinical Trials Partnership, Agnandji ST, Lell B, Soulanoudjingar SS, Fernandes JF, Abossolo BP, et al. First results of Phase 3 trial of RTS,S/AS01 malaria vaccine in African children. N Engl J Med. 2011;365(20):1863–75. http://www.ncbi.nlm.nih.gov/pubmed/22007715; RTS,S Clinical Trials Partnership, Agnandji ST, Lell B, Fernandes JF, Abossolo BP, Methogo BGNO, et al. A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants. N Engl J Med. 2012 Dec 13;367(24):2284.

    Article  Google Scholar 

  21. RTS,S Clinical Trials Partnership. Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. Lancet. 2015;386(9988):31–45.

    Article  Google Scholar 

  22. European Medicines Agency. First malaria vaccine receives positive scientific opinion from EMA [Internet]. Available from: www.ema.europa.eu.

  23. Vekemans J, Schellenberg D, Benns S, et al. Meeting report: WHO consultation on malaria vaccine development, Geneva, 15–16 July 2019. Vaccine. 2021;39:2907–16.

    Article  PubMed  Google Scholar 

Download references

Acknowledgement

The authors would like to thank Dr. Mary Hamel, from WHO, for her kind review of the malaria vaccine section.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christian Lienhardt .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Lienhardt, C., Cobelens, F. (2023). How Innovations Can Impact on people’s Life: The Continuum of Research in Global Health. In: Raviglione, M.C.B., Tediosi, F., Villa, S., Casamitjana, N., Plasència, A. (eds) Global Health Essentials. Sustainable Development Goals Series. Springer, Cham. https://doi.org/10.1007/978-3-031-33851-9_60

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-33851-9_60

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-33850-2

  • Online ISBN: 978-3-031-33851-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics