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Cardiac Pacemaking Is an Emergent Property of Complex Synchronized Signaling on Multiple Scales

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Heart Rate and Rhythm

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Abstract

The generation of automaticity in the sinoatrial node is a multiscale process involving the integration of complex biochemical and biophysical processes, including a membrane clock and a calcium clock operating in a coupled-clock system within single cells and further complex integration of heterogeneous intercellular signaling at the tissue level. Our current understanding of these processes is reviewed in detail. Ground-breaking recent studies in intact SAN have discovered a new paradigm of SAN operation, and this, along with other frontiers in pacemaker research, are addressed.

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Acknowledgments

This research was supported by the Intramural Research Program of the National Institutes of Health and the National Institute on Aging.

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Authors and Affiliations

  1. Laboratory of Cardiovascular Science, NIA (IRP), NIH, Baltimore, MD, USA

    Oliver Monfredi, Victor A. Maltsev & Edward G. Lakatta

  2. University of Virginia Medical Center, Charlottesville, VA, USA

    Oliver Monfredi & David Kim

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  1. Oliver Monfredi
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  2. David Kim
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  3. Victor A. Maltsev
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  4. Edward G. Lakatta
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Correspondence to Edward G. Lakatta .

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Editors and Affiliations

  1. Cardiac Electrophysiology Division, Ion Channel Study Center, Life Science Academy, Lucknow, India

    Onkar N. Tripathi

  2. Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada

    T. Alexander Quinn

  3. Institute for Experimental Cardiovascular Medicine, University Heart Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Ursula Ravens

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Monfredi, O., Kim, D., Maltsev, V.A., Lakatta, E.G. (2023). Cardiac Pacemaking Is an Emergent Property of Complex Synchronized Signaling on Multiple Scales. In: Tripathi, O.N., Quinn, T.A., Ravens, U. (eds) Heart Rate and Rhythm. Springer, Cham. https://doi.org/10.1007/978-3-031-33588-4_5

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  • DOI: https://doi.org/10.1007/978-3-031-33588-4_5

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