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Implications of Sarcolemmal Ca2+-Handling Proteins in Heart Function in Health and Disease

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Heart Rate and Rhythm

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Abstract

A small amount of Ca2+ enters the cell through the sarcolemmal membrane, releases an additional amount of Ca2+ from the sarcoplasmic reticulum, and initiates myocardial contraction. The contraction process is terminated upon lowering the cytosolic Ca2+ by accumulation in the sarcoplasmic reticulum as well as removal into the extracellular space through the sarcolemmal membrane. This article describes sarcolemmal L-type Ca2+ channel, Na+–Ca2+ exchanger, store-operated Ca2+ channels, Ca2+-pump ATPase, Ca2+/Mg2+ecto-ATPase, Na+-H+ exchanger, and Na+-K+ ATPase, which directly or indirectly regulate the movements of Ca2+ in cardiomyocytes. The pharmacological modulation of these Ca2+-handling proteins has been indicated to gain information regarding the regulation of intracellular Ca2+ in cardiomyocytes. Furthermore, alterations in the sarcolemmal Ca2+-handling proteins in different cardiovascular pathologies have been identified to emphasize the Ca2+-handling abnormalities in cardiomyocytes during the development of cardiac dysfunction in heart disease.

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Acknowledgements

The infrastructural support for this article was provided by the St. Boniface Hospital Research Foundation.

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Authors and Affiliations

  1. Asper Clinical Research Institute, St. Boniface Hospital, Winnipeg, Canada

    Paramjit S. Tappia

  2. Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Canada

    Sukhwinder K. Bhullar

  3. School of Kinesiology, Nutrition and Food Science, California State University, Los Angeles, USA

    Anureet K. Shah

  4. Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre and Department of Physiology and Pathophysiology, College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla

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  1. Paramjit S. Tappia
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  2. Sukhwinder K. Bhullar
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  3. Anureet K. Shah
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  4. Naranjan S. Dhalla
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Corresponding author

Correspondence to Naranjan S. Dhalla .

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Editors and Affiliations

  1. Cardiac Electrophysiology Division, Ion Channel Study Center, Life Science Academy, Lucknow, India

    Onkar N. Tripathi

  2. Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada

    T. Alexander Quinn

  3. Institute for Experimental Cardiovascular Medicine, University Heart Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Ursula Ravens

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Tappia, P.S., Bhullar, S.K., Shah, A.K., Dhalla, N.S. (2023). Implications of Sarcolemmal Ca2+-Handling Proteins in Heart Function in Health and Disease. In: Tripathi, O.N., Quinn, T.A., Ravens, U. (eds) Heart Rate and Rhythm. Springer, Cham. https://doi.org/10.1007/978-3-031-33588-4_20

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