Skip to main content
SpringerLink
Log in

Acknowledged Therapeutic Options in Nose Vestibule Malignancies

  • Chapter
  • First Online:
Malignancies of the Nasal Vestibule

  • 99 Accesses

Abstract

Squamous cell carcinoma (SCC) of nasal vestibule (NV) is a relatively uncommon malignancy of the midface region. Because of its rarity and inconsistencies in classification and staging (see Chaps. 4 and 5), there is no standard treatment in literature.

Radiotherapy and surgery are possible options, but there is no universal agreement about indications.

Surgery is often selected in case of small lesions without necessity of reconstruction, or in case of recurrence (salvage surgery), but aesthetic and functional results of the reconstructive phase are generally unsatisfactory.

Radiotherapy can be performed by external beam or brachytherapy.

The modality for neck treatment in the primary setting usually follows the modality chosen for T.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Vital D, Morand G, Huber GF, Studer G, Holzmann D. Outcome in squamous cell carcinoma of the nasal vestibule: a single center experience. Head Neck. 2015;37:46–51.

    Article  PubMed  Google Scholar 

  2. Bussu F, et al. New standards for the management of nose vestibule malignancies Acta Oto-Laryngologica. 2023;143(3):215–22. https://doi.org/10.1080/00016489.2023.2179662.

  3. Bussu F, Tagliaferri L, Piras A, Rizzo D, Tsatsaris N, De Corso E et al. Multidisciplinary approach to nose vestibule malignancies: setting new standards Approccio multidisciplinare ai tumori maligni del vestibolo del naso: verso la definizione di nuovi standard Acta Otorhinolaryngologica Italica. 2021;41(Suppl. 1):S158–S165. https://doi.org/10.14639/0392-100X-suppl.1-41-2021-16.

  4. Dowley A, Hoskison E, Allibone R, Jones NS. Squamous cell carcinoma of the nasal vestibule: a 20-year case series and literature review. J Laryngol Otol. 2008;122:1019–23.

    Article  CAS  PubMed  Google Scholar 

  5. Zaoui K, Plinkert PK, Federspil PA. Primary surgical treatment of nasal vestibule cancer—therapeutic outcome and reconstructive strategies. Rhinology. 2018;56:393–9.

    CAS  PubMed  Google Scholar 

  6. Evaluation of Staging Systems for Cancer of the Nasal Vestibule Cancers. 2023;15(11):3028. https://doi.org/10.3390/cancers15113028.

  7. Goepfert H, Guillamondegui OM, Jesse RH, Lindberg RD. Squamous cell carcinoma of nasal vestibule. Arch Otolaryngol. 1974;100:8–10.

    Article  CAS  PubMed  Google Scholar 

  8. Kagan AR, Nussbaum H, Rao A, Chan P, Gilbert H, Hintz B, Ryoo M, Miles J, Rice D. The management of carcinoma of the nasal vestibule. Head Neck Surg. 1981;4:125–8.

    Article  CAS  PubMed  Google Scholar 

  9. Weinberger JM, Briant TD, Cummings BJ, Wong CS. The role of surgery in the treatment of squamous cell carcinoma of the nasal vestibule. J Otolaryngol. 1988;17:372–5.

    CAS  PubMed  Google Scholar 

  10. Patel P, Tiwari R, Karim AB, Nauta JJ, Snow GB. Squamous cell carcinoma of the nasal vestibule. J Laryngol Otol. 1992;106:332–6.

    Article  CAS  PubMed  Google Scholar 

  11. Pantelakos ST, McGuirt WF, Nussear DW. Squamous cell carcinoma of the nasal vestibule and anterior nasal passages. Am J Otolaryngol. 1994;15:33–6.

    Article  CAS  PubMed  Google Scholar 

  12. Fornelli RA, Fedok FG, Wilson EP, Rodman SM. Squamous cell carcinoma of the anterior nasal cavity: a dual institution review. Otolaryngol Head Neck Surg. 2000;123:207–10.

    Article  CAS  PubMed  Google Scholar 

  13. Agger A, von Buchwald C, Madsen AR, et al. Squamous cell carcinoma of the nasal vestibule 1993-2002: a nationwide retrospective study from DAHANCA. Head Neck. 2009;31:1593–9.

    Article  PubMed  Google Scholar 

  14. Ledderose GJ, Reu S, Englhard AS, Krause E. Endonasal resection of early stage squamous cell carcinoma of the nasal vestibule. Eur Arch Otorhinolaryngol. 2014;271:1051–5.

    Article  PubMed  Google Scholar 

  15. Federspil PA, Plinkert PK, Zaoui K. Early nasal reconstruction after skin-preserving excision of squamous cell carcinoma of the nasal vestibule. J Plast Reconstr Aesthet Surg. 2020;73:1683–91.

    Article  CAS  PubMed  Google Scholar 

  16. Lambertoni A, Cherubino M, Battaglia P, et al. Squamous cell carcinoma of nasal vestibule and pyramid: outcomes and reconstructive strategies. Laryngoscope. 2021;131:E1198–208.

    Article  PubMed  Google Scholar 

  17. Chabrillac E, Talawdekar A, Garikipati S, Varley I, Sionis S, Beasley N, Jackson R. A single centre’s experience of 23 cases of total rhinectomy for the treatment of squamous cell carcinoma involving the nasal vestibule. Eur Arch Otorhinolaryngol. 2021;279:2069. https://doi.org/10.1007/s00405-021-06972-6.

    Article  PubMed  Google Scholar 

  18. Wang CC. Treatment of carcinoma of the nasal vestibule by irradiation. Cancer. 1976;38:100–6.

    Article  CAS  PubMed  Google Scholar 

  19. Mak ACA, van Andel JG, Van Woerkom-Eijkenboom WMH. Radiation therapy of carcinoma of the nasal vestibule. Eur J Cancer. 1980;16:81–5.

    Article  CAS  Google Scholar 

  20. Jong JMA, Schalekamp W, Hordijk GJ. Squamous carcinoma of the nasal vestibule. Clin Otolaryngol. 1981;6:205–8.

    Article  PubMed  Google Scholar 

  21. Chassagne D, Wilson JF. Brachytherapy of carcinomas of the nasal vestibule. Int J Radiat Oncol Biol Phys. 1984;10:761.

    Article  CAS  PubMed  Google Scholar 

  22. Johansen LV, Hjelm-Hansen M, Andersen AP. Squamous cell carcinoma of the nasal vestibule. Treatment results. Acta Radiol Oncol. 1984;23:189–92.

    Article  CAS  PubMed  Google Scholar 

  23. Baris G, Visser AG, van Andel JG. The treatment of squamous cell carcinoma of the nasal vestibule with interstitial iridium implantation. Radiother Oncol. 1985;4:121–5.

    Article  CAS  PubMed  Google Scholar 

  24. Wong CS, Cummings BJ, Elhakim T, Briant TD. External irradiation for squamous cell carcinoma of the nasal vestibule. Int J Radiat Oncol Biol Phys. 1986;12:1943–6.

    Article  CAS  PubMed  Google Scholar 

  25. Jeannon J-P, Riddle PJ, Irish J, O’sullivan B, Brown DH, Gullane P. Prognostic indicators in carcinoma of the nasal vestibule. Clin Otolaryngol. 2007;32:19–23.

    Article  PubMed  Google Scholar 

  26. Haynes WD, Ducote Haynes W, Tapley ND. Radiation treatment of carcinoma of the nasal vestibule. Am J Roentgenol. 1974;120:595–602.

    Article  CAS  Google Scholar 

  27. Chobe R, McNeese M, Weber R, Fletcher GH. Radiation therapy for carcinoma of the nasal vestibule. Otolaryngol Head Neck Surg. 1988;98:67–71.

    Article  CAS  PubMed  Google Scholar 

  28. Levendag PC, Pomp J. Radiation therapy of squamous cell carcinoma of the nasal vestibule. Int J Radiat Oncol Biol Phys. 1990;19:1363–7.

    Article  CAS  PubMed  Google Scholar 

  29. Levendag PC, Nijdam WM, van Moolenburgh SE, Tan L, Noever I, van Rooy P, Mureau MAM, Jansen PP, Munte K, Hofer SOP. Interstitial radiation therapy for early-stage nasal vestibule cancer: a continuing quest for optimal tumor control and cosmesis. Int J Radiat Oncol Biol Phys. 2006;66:160–9.

    Article  PubMed  Google Scholar 

  30. Poulsen M, Turner S. Radiation therapy for squamous cell carcinoma of the nasal vestibule. Int J Radiat Oncol Biol Phys. 1993;27:267–72.

    Article  CAS  PubMed  Google Scholar 

  31. Turner SL, Lochrin CA, Dische S, Saunders MI, Maher EJ. Continuous hyperfractionated accelerated radiotherapy in the treatment of carcinoma of the columella and vestibule of the nose. Eur J Cancer B Oral Oncol. 1995;31B:368–72.

    Article  CAS  PubMed  Google Scholar 

  32. Evensen JF, Jacobsen AB, Tausjø JE. Brachytherapy of squamous cell carcinoma of the nasal vestibule. Acta Oncol. 1996;35(Suppl 8):87–92.

    Article  PubMed  Google Scholar 

  33. Mendenhall WM, Stringer SP, Cassisi NJ, Mendenhall NP. Squamous cell carcinoma of the nasal vestibule. Head Neck. 1999;21:385–93.

    Article  CAS  PubMed  Google Scholar 

  34. Wray J, Morris CG, Kirwan JM, Amdur RJ, Werning JW, Dziegielewski PT, Mendenhall WM. Radiation therapy for nasal vestibule squamous cell carcinoma: a 40-year experience. Eur Arch Otorhinolaryngol. 2016;273:661–9.

    Article  PubMed  Google Scholar 

  35. Langendijk JA, Poorter R, Leemans CR, de Bree R, Doornaert P, Slotman BJ. Radiotherapy of squamous cell carcinoma of the nasal vestibule. Int J Radiat Oncol Biol Phys. 2004;59:1319–25.

    Article  PubMed  Google Scholar 

  36. Lipman D, Verhoef LC, Takes RP, Kaanders JH, Janssens GO. Outcome and toxicity profile after brachytherapy for squamous cell carcinoma of the nasal vestibule. Head Neck. 2015;37:1297–303.

    Article  PubMed  Google Scholar 

  37. Czerwinski MD, van Leeuwen RGH, Kaanders JHAM, Zwijnenburg EM, Lipman D, Takes RP, Verhoef CG. Image guided brachytherapy for cancer of the nasal vestibule: local control and cosmesis. Int J Radiat Oncol Biol Phys. 2019;103:913–21.

    Article  PubMed  Google Scholar 

  38. Vanneste BGL, Lopez-Yurda M, Tan IB, Balm AJM, Borst GR, Rasch CR. Irradiation of localized squamous cell carcinoma of the nasal vestibule. Head Neck. 2016;38(Suppl 1):E1870–5.

    PubMed  Google Scholar 

  39. Bussu F, Tagliaferri L, Mattiucci G, et al. Comparison of interstitial brachytherapy and surgery as primary treatments for nasal vestibule carcinomas. Laryngoscope. 2016;126:367–71.

    Article  PubMed  Google Scholar 

  40. Tagliaferri L, Carra N, Lancellotta V, et al. Interventional radiotherapy as exclusive treatment for primary nasal vestibule cancer: single-institution experience. J Contemp Brachytherapy. 2020;12:413–9.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Czerwinski MD, Jansen PP, Zwijnenburg EM, Al-Mamgani A, Vergeer MR, Langendijk JA, Wesseling FWR, Kaanders JHAM, Verhoef CG. Radiotherapy as nose preservation treatment strategy for cancer of the nasal vestibule: the Dutch experience. Radiother Oncol. 2021;164:20–6.

    Article  PubMed  Google Scholar 

  42. DesPrez JD, Kiehn CL. Carcinoma of the nasal vestibule. Am J Surg. 1967;114:587–91.

    Article  CAS  PubMed  Google Scholar 

  43. Mendenhall NP, Parsons JT, Cassisi NJ, Million RR. Carcinoma of the nasal vestibule. Int J Radiat Oncol Biol Phys. 1984;10:627–37.

    Article  CAS  PubMed  Google Scholar 

  44. Mendenhall NP, Parsons JT, Cassisi NJ, Million RR. Carcinoma of the nasal vestibule treated with radiation therapy. Laryngoscope. 1987;97:626–32.

    Article  CAS  PubMed  Google Scholar 

  45. Mazeron JJ, Chassagne D, Crook J, Bachelot F, Brochet F, Brune D, Brunin F, Bunescu U, Daly N, Danczak S. Radiation therapy of carcinomas of the skin of nose and nasal vestibule: a report of 1676 cases by the Groupe Europeen de Curiethérapie. Radiother Oncol. 1988;13:165–73.

    Article  CAS  PubMed  Google Scholar 

  46. McCollough WM, Mendenhall NP, Parsons JT, Mendenhall WM, Stringer SP, Cassisi NJ, Million RR. Radiotherapy alone for squamous cell carcinoma of the nasal vestibule: management of the primary site and regional lymphatics. Int J Radiat Oncol Biol Phys. 1993;26:73–9.

    Article  CAS  PubMed  Google Scholar 

  47. Wallace A, Morris CG, Kirwan J, Amdur RJ, Werning JW, Mendenhall WM. Radiotherapy for squamous cell carcinoma of the nasal vestibule. Am J Clin Oncol. 2007;30:612–6.

    Article  PubMed  Google Scholar 

  48. Koopmann M, Weiss D, Savvas E, Rudack C, Stenner M. Clinicopathological and immunohistochemical characteristics of surgically treated primary carcinoma of the nasal vestibule—an evaluation of 30 cases. Clin Otolaryngol. 2015;40:240–7.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Otolaryngology Division, Azienda Ospedaliero Universitaria Sassari, Sassari, Italy

    Tropiano Paolo, Fois Paolo, Melis Andrea, Laura Maria De Luca & Davide Rizzo

  2. Radiotherapy Division, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy

    Francesco Miccichè, Andrea D’Aviero & Luca Tagliaferri

  3. Radiation Oncology Division, Sassari University Hospital, Sassari, Italy

    Di Mario Dalila

  4. Medical Oncology Division, Sassari University Hospital, Sassari, Italy

    Giovanni Maria Fadda

  5. Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy

    Davide Rizzo

Authors
  1. Tropiano Paolo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fois Paolo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Melis Andrea
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Laura Maria De Luca
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Francesco Miccichè
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Di Mario Dalila
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Andrea D’Aviero
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Giovanni Maria Fadda
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Luca Tagliaferri
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Davide Rizzo
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy

    Francesco Bussu

Rights and permissions

Reprints and permissions

Copyright information

© 2023 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Paolo, T. et al. (2023). Acknowledged Therapeutic Options in Nose Vestibule Malignancies. In: Bussu, F. (eds) Malignancies of the Nasal Vestibule. Springer, Cham. https://doi.org/10.1007/978-3-031-32850-3_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-32850-3_6

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-32849-7

  • Online ISBN: 978-3-031-32850-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation