Abstract
Rodent models have been extensively used to study the neural underpinnings of aggression. Yet, the role of some external factors such as social experiences, or internal factors such as biological sex, have only recently gained attention. This chapter discusses how the composition of the social environment and/or the lack of social contact (social isolation) in different stages of development impact the display of aggressive behavior in rodents. Additionally, this chapter covers how biological sex interacts with changes in the composition of the social environment to affect the neuronal networks of aggression. From a neurobiological point of view, this chapter focuses particularly on the participation of neuroendocrine systems such as sex hormones, oxytocin, and vasopressin and on how social interactions shape brain plasticity within those systems.
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Abbreviations
- AH:
-
Anterior hypothalamus
- AVP:
-
Vasopressin
- BDNF:
-
Brain-derived neurotrophic factor
- BLA:
-
Basolateral amygdala
- BNST:
-
Bed nucleus of stria terminalis
- CCKA:
-
Cholecystokinin receptor A
- CeA:
-
Central amygdala
- CSF:
-
Cerebrospinal fluid
- DG:
-
Dentate gyrus
- dLS:
-
Dorsal lateral septum
- DMH:
-
Dorsomedial hypothalamus
- DR1:
-
Dopamine receptor 1
- DR2:
-
Dopamine receptor 2
- EPCs:
-
Excitatory postsynaptic currents
- Erα:
-
Estrogen receptor alpha
- FMRP:
-
Fragile X mental retardation protein
- GH:
-
Group-housed
- HAA:
-
Hypothalamic attack area (mediobasal hypothalamus)
- IL:
-
Infralimbic cortex
- IST:
-
Isolated and trained
- LH:
-
Lateral hypothalamus
- LS:
-
Lateral septum
- LTD:
-
Long-term depression
- LTP:
-
Long-term potentiation
- MeA:
-
Medial amygdala
- MeApv:
-
Medial amygdala posteroventral
- mGluR5:
-
Metabotropic glutamate receptor 5
- MPOA:
-
Medial preoptic area
- Nacc:
-
Nucleus accumbens
- NK3R:
-
Neuorkinin receptor 3
- NKB:
-
Neurokinin B
- nNOS:
-
Neuronal nitric oxide synthase
- NO:
-
Nitric oxide
- NPY2:
-
Neuropeptide Y receptor 2
- OF:
-
Orbitofrontal cortex
- OXT:
-
Oxytocin
- OXTR:
-
Oxytocin receptor
- PAG:
-
Periaqueductal gray matter
- PFC:
-
Prefrontal cortex
- PR:
-
Progesterone receptor
- PrL:
-
Prelimbic cortex
- PVN:
-
Paraventricular nucleus of the hypothalamus
- PWSI:
-
Postweaning social isolation
- RIT:
-
Resident Intruder Test
- SI:
-
Social Isolation
- SON:
-
Supraoptic nucleus of the hypothalamus
- TAC2:
-
Tachykinin 2
- V1aR:
-
Vasopressin 1a receptor
- vLS:
-
Ventral lateral septum
- VMHvl:
-
Ventrolateral ventromedial hypothalamus
- VTA:
-
Ventral tegmental area
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Acknowledgements
This work was supported by the Fonds de la Recherche Scientifique -FNRS CR 40011133 AGGRESSIONKiNG project and by the Fondation Léon Fredericq Bourse de fonctionnement Post-Doctorant (Neuromodulation of aggression by kisspeptin, neurokinin B, and GnRH).
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Oliveira, V.E.d.M. (2023). Animal Models of Aggression. In: Martin, C.R., Preedy, V.R., Patel, V.B. (eds) Handbook of Anger, Aggression, and Violence. Springer, Cham. https://doi.org/10.1007/978-3-031-31547-3_144
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