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Interstitial Cystitis/Bladder Pain Syndrome

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Managing Psychosexual Consequences in Chronic Diseases

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Abstract

Painful bladder syndrome or interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic debilitating disease, defined by a variable combination of symptoms during micturition and sexual intercourse.

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References

  1. Jhang J-F, Kuo H-C. Patho-mechanism of interstitial cystitis/bladder pain syndrome and mapping the heterogeneity of disease. Int Neurourol J. 2016;20(Suppl 2):S95–104.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Huffmann M, Slak A, Hoke M. Bladder pain syndrome. Prim Care. 2019;46(2):213–21.

    Article  Google Scholar 

  3. Koziol JA. Epidemiology of interstitial cystitis. Urol Clin North Am. 1994;21(1):7–20.

    Article  CAS  PubMed  Google Scholar 

  4. Huffman MM, Slack A, Hoke M. Bladder pain syndrome. Prim Care. 2019;46(2):213–21.

    Article  PubMed  Google Scholar 

  5. Chaiken DC, Blaivas JG, Blaivas ST. Behavioral therapy for the treatment of refractory interstitial cystitis. J Urol. 1993;149(06):1445–8.

    Article  CAS  PubMed  Google Scholar 

  6. Christofi N, Hextall A. An evidence-based approach to lifestyle interventions in urogynaecology. Menopause Int. 2007;13(04):154–8.

    Article  PubMed  Google Scholar 

  7. Parsons CL, Koprowski PF. Interstitial cystitis: successful management by increasing urinary voiding intervals. Urology. 1991;37(03):207–12.

    Article  CAS  PubMed  Google Scholar 

  8. FitzGerald MP, Payne CK, Lukacz ES, et al. Randomized multicenter clinical trial of myofascial physical therapy in women with interstitial cystitis/painful bladder syndrome and pelvic floor tenderness. J Urol. 2012;187(6):2113–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Moldwin RM, Fariello JY. Myofascial trigger points of the pelvic floor: associations with urological pain syndromes and treatment strategies including injection therapy. Curr Urol Rep. 2013;14(5):409–17.

    Article  PubMed  Google Scholar 

  10. Weiss JM. Pelvic floor myofascial trigger points: manual therapy for interstitial cystitis and the urgency-frequency syndrome. J Urol. 2001;166(06):2226–31.

    Article  CAS  PubMed  Google Scholar 

  11. Whitmore KE. Self-care regimens for patients with interstitial cystitis. Urol Clin North Am. 1994;21(01):121–30.

    Article  CAS  PubMed  Google Scholar 

  12. Webster DC, Brennan T. Use and effectiveness of physical self- care strategies for interstitial cystitis. Nurse Pract. 1994;19(10):55–61.

    Article  CAS  PubMed  Google Scholar 

  13. Lee S-H, Lee B-C. Use of acupuncture as a treatment method for chronic prostatitis/chronic pelvic pain syndromes. Curr Urol Rep. 2011;12(4):288–96.

    Article  CAS  PubMed  Google Scholar 

  14. Colaco MA, Evans RJ. Current recommendations for bladder instillation therapy in the treatment of interstitial cystitis/bladder pain syndrome. Curr Urol Rep. 2013;14(5):442–7.

    Article  PubMed  Google Scholar 

  15. Dyer AJ, Twiss CO. Painful bladder syndrome: an update and review of current management strategies. Curr Urol Rep. 2014;15(2):384.

    Article  PubMed  Google Scholar 

  16. Marcu I, Campian EC, Tu FF. Interstitial cystitis/bladder pain syndrome. Semin Reprod Med. 2018;36:123–35.

    Article  PubMed  Google Scholar 

  17. Ahmad I, Sarath KN, Meddings RN. Sequential hydrodistention and intravesical instillation of hyaluronic acid under general anaesthesia for treatment of refractory interstitial cystitis: a pilot study. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19(4):543–6.

    Article  PubMed  Google Scholar 

  18. Platte RO, Parekh M, Minassian VA, Poplawsky D. Spontaneous bladder rupture following cystoscopy with hydrodistention and biopsy in a female patient with interstitial cystitis. Female Pelvic Med Reconstr Surg. 2011;17(3):149–52.

    Article  PubMed  Google Scholar 

  19. Jhang J-F, Kuo H-C. Patho-mechanism of interstitial cystitis/bladder pain syndrome and mapping the heterogeneity of disease. Int Neurourol J. 2016;20(2):95–104.

    Article  Google Scholar 

  20. Cervigni M, Nasta L, Schievano C, Lampropoulou N, Ostardo E. Micronized palmitoylethanolamide-polydatin reduces the painful symptomatology in patients with interstitial cystitis/bladder pain syndrome. Biomed Res Int. 2019;2019:9828397.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Sant GR. Etiology, pathogenesis, and diagnosis of interstitial cystitis. Rev Urol. 2002;4(1):9–15.

    Google Scholar 

  22. Grover S, Srivastava A, Lee R, et al. Role of inflammation in bladder function and interstitial cystitis. Ther Adv Urol. 2011;3(1):19–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Davis NF, Brady CM, Creagh T. Interstitial cystitis/painful bladder syndrome: epidemiology, pathophysiology and evidence-based treatment options. Eur J Obstet Gynecol Reprod Biol. 2014;175:30–7.

    Article  CAS  PubMed  Google Scholar 

  24. McLennan MT. Interstitial cystitis: epidemiology, pathophysiology, and clinical presentation. Obstet Gynecol Clin N Am. 2014;41(3):385–95.

    Article  Google Scholar 

  25. Davis NF, Gnanappiragasam S, Thornhill JA. Interstitial cystitis/painful bladder syndrome: the influence of modern diagnostic criteria on epidemiology and on Internet search activity by the public. Transl Androl Urol. 2015;4(5):506–51.

    PubMed  PubMed Central  Google Scholar 

  26. Hanno PM, Burks DA, Clemens JQ, et al. AUA guideline for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome. J Urol. 2014;185(6):2162–70.

    Article  Google Scholar 

  27. Cox A, Golda N, Nadeau G, et al. CUA guideline: diagnosis and treatment of interstitial cystitis/bladder pain syndrome. Can Urol Assoc J. 2016;10(5–6):E136.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Berry SH, Elliott MN, Suttorp M, et al. Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States. J Urol. 2011;186(2):540–4.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Jones CA, Nyberg L. Epidemiology of interstitial cystitis. Urology. 1997;49(5):2–9.

    Article  CAS  PubMed  Google Scholar 

  30. Clemens JQ, Link CL, Eggers PW, Kusek JW, Nyberg LM Jr, McKinlay JB, BACH Survey Investigators. Prevalence of painful bladder symptoms and effect on quality of life in black, hispanic and white men and women. J Urol. 2007;177(4):1390–4.

    Article  PubMed  Google Scholar 

  31. van de Merwe JP, Nordling J, Bouchelouche P, et al. Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur Urol. 2008;53(1):60–7.

    Article  PubMed  Google Scholar 

  32. Malde S, Palmisani S, Al-Kaisy A, Sahai A. Guideline of guidelines: bladder pain syndrome. BJU Int. 2018;122(5):729–43.

    Article  PubMed  Google Scholar 

  33. Warren JW, Brown J, Tracy JK, Langenberg P, Wesselmann U, Greenberg P. Evidence-based criteria for pain of interstitial cystitis/painful bladder syndrome in women. Urology. 2008;71:444–8.

    Article  PubMed  Google Scholar 

  34. Abrams P, Baranowski A, Berger RE, Fall M, Hanno P, Wesselmann U. A new classification is needed for pelvic pain syndromes–are existing terminologies of spurious diagnostic authority bad for patients? J Urol. 2006;175(6):1989–90.

    Article  PubMed  Google Scholar 

  35. Gillenwater JY, Wein AJ. Summary of the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases Workshop on Interstitial Cystitis, National Institute of Health, Bethesda, Maryland, August 28-29, 1987. Urology. 1988;140(1):203–6.

    Article  CAS  Google Scholar 

  36. Driscoll A, Teichman JM. How do patients with interstitial cystitis present? J Urol. 2001;166:2118–20.

    Article  CAS  PubMed  Google Scholar 

  37. Ito T, Ueda T, Homma Y, Takei M. Recent trends in patient characteristics and therapeutic choices for interstitial cystitis: analysis of 282 Japanese patients. Int J Urol. 2007;14:1068–70.

    Article  PubMed  Google Scholar 

  38. Parsons CL. Interstitial cystitis: epidemiology and clinical presentation. Clin Obstet Gynecol. 2002;45(1):242–9.

    Article  PubMed  Google Scholar 

  39. Parsons CL, Bullen M, Kahn BS, Stanford EJ, Willems JJ. Gynecologic presentation of interstitial cystitis as detected by intravesical potassium sensitivity. Obstet Gynecol. 2001;98(1):127–32.

    CAS  PubMed  Google Scholar 

  40. Shorter B, Lesser M, Moldwin RM, Kushner L. Effect of comestibles on symptoms of interstitial cystitis. J Urol. 2007;178(1):145–52.

    Article  PubMed  Google Scholar 

  41. Rudick CN, Chen MC, Mongiu AK, Klumpp DJ. Organ cross talk modulates pelvic pain. Am J Physiol Regul Integr Comp Physiol. 2007;293(3):R1191–8.

    Article  CAS  PubMed  Google Scholar 

  42. Christianson JA, Liang R, Ustinova EE, Davis BM, Fraser MO, Pezzone MA. Convergence of bladder and colon sensory innervation occurs at the primary afferent level. Pain. 2007;128(3):235–43.

    Article  PubMed  Google Scholar 

  43. Friedlander JI, Shorter B, Moldwin RM. Diet and its role in interstitial cystitis/bladder pain syndrome (IC/BPS) and comorbid conditions. BJU Int. 2012;109(11):1584–91.

    Article  PubMed  Google Scholar 

  44. Herati AS, Shorter B, Srinivasan AK, et al. Effects of foods and beverages on the symptoms of chronic prostatitis/chronic pelvic pain syndrome. Urology. 2013;82(6):1376–80.

    Article  PubMed  Google Scholar 

  45. Alagiri M, Chottiner S, Ratner V, Slade D, Hanno PM. Interstitial cystitis: unexplained associations with other chronic disease and pain syndromes. Urology. 1997;49(5):52–7.

    Article  CAS  PubMed  Google Scholar 

  46. Rodríguez MAB, Afari N, Buchwald DS, National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Urological Chronic Pelvic Pain. Evidence for overlap between urological and nonurological unexplained clinical conditions. J Urol. 2009;182(5):2123–31.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Nickel JC, Tripp DA, Pontari M, et al. Psychosocial phenotyping in women with interstitial cystitis/painful bladder syndrome: a case control study. J Urol. 2010;183(1):167–72.

    Article  PubMed  Google Scholar 

  48. Birder LA, Hanna-Mitchell AT, Mayer E, Buffington CA. Cystitis, co-morbid disorders and associated epithelial dysfunction. Neurourol Urodyn. 2011;30(5):668–72.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Nastaskin I, Mehdikhani E, Conklin J, Park S, Pimentel M. Studying the overlap between IBS and GERD: a systematic review of the literature. Dig Dis Sci. 2006;51(12):2113–20.

    Article  PubMed  Google Scholar 

  50. Messing E, Pauk D, Shaeffer A, et al. Associations among cystoscopic findings and symptoms and physical examination findings in women enrolled in the Interstitial Cystitis Data Base (ICDB) Study. Urology. 1997;49(5):81–5.

    Article  CAS  PubMed  Google Scholar 

  51. Lamale LM, Lutgendorf SK, Hoffman AN, Kreder KJ. Symptoms and cystoscopic findings in patients with untreated interstitial cystitis. Urology. 2006;67:242–5.

    Article  PubMed  Google Scholar 

  52. Bosch PC. Examination of the significant placebo effect in the treatment of interstitial cystitis/bladder pain syndrome. Urology. 2014;84(2):321–6.

    Article  PubMed  Google Scholar 

  53. Rapkin AJ, Kames LD. The pain management approach to chronic pelvic pain. J Reprod Med. 1987;32(5):323–7.

    CAS  PubMed  Google Scholar 

  54. Kosek E, Hansonn P. Modulatory influence on the perception of vibration and thus heterosensory conditioning (HNCS) in patients with fibromyalgia and health subjects. Ache. 1997;70(1):41–51.

    CAS  Google Scholar 

  55. Julien N, Goffaux P, Arsenault P, Marchand S. Diffuse pain in fibromyalgia is related to a deficiency in endogenous pain inhibition. Ache. 2005;114(1-2):295–302.

    Google Scholar 

  56. Freemason P. Medullary circuits for nociceptive modulation. Curr Opin Neurobiol. 2012;22(4):640–5.

    Article  Google Scholar 

  57. Plaghki L, Mouraux A, Le Bars D. Pain physiology. EMC Rehabil Med. 2018;25(1):1–22.

    Google Scholar 

  58. Chiu B, Tai HC, Chung SD, Birder LA. Botulinum toxin A for bladder pain syndrome/interstitial cystitis. Toxins. 2016;8:201.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Bogart LM, Suttorp MJ, Elliott MN, Clemens JQ, Berry SH. Prevalence and correlations of sexual dysfunction among women with bladder pain syndrome/interstitial cystitis. Urology. 2011;77:576–80.

    Article  PubMed  Google Scholar 

  60. Puliatti M, Fiacchi S, Silipigni F. Psychological aspects and psychotherapy of women with interstitial cystitis. Cognitive-behavioral therapy and EMDR: an integrated approach [Psychological aspects and psychotherapy of women with interstitial cystitis]. Cognitive-behavioral therapy and EMDR: an integrated approach. Psychosom Med. 2007;52(3):101–3.

    Google Scholar 

  61. Clauw DJ, Schmidt M, Radulovic D, et al. The relationship between fibromyalgia and interstitial cystitis. J Psychiatr Res. 1997;31:125–31.

    Article  CAS  PubMed  Google Scholar 

  62. Sutcliffe S, Colditz GA, Pakpahan R, et al. Changes in symptoms during urologic chronic pelvic pain syndrome symptom flares: findings from one site of the MAPP Research Network. Neurourol Urodyn. 2013;34(2):188–95.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Davisa NF, Bradyb CM, Creagha T. Interstitial cystitis/painful bladder syndrome: epidemiology, pathophysiology and evidence based treatment options. Eur J Obstet Gynecol Reprod Biol. 2014;175C:30–7.

    Article  Google Scholar 

  64. Persu C, Cauni V, Gutue S, et al. From interstitial cystitis to chronic pelvic pain. J Med Life. 2010;3:167–74.

    CAS  PubMed  PubMed Central  Google Scholar 

  65. Berry SH, Hayes RD, Suttorp M, et al. Health-related quality of life impact of interstitial cystitis/painful bladder syndrome and other symptomatic disorders. Qual Life Res. 2013;22:1537–41.

    PubMed  Google Scholar 

  66. Vesela R, Aronsson P, Andersson M, et al. The potential of non-adrenergic, non-cholinergic targets in the treatment of interstitial cystitis/painful bladder syndrome. J Physiol Pharmacol. 2012;63:209–16.

    CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Urotechnology Center, Scientific Institute “Istituto Auxologico Italiano”, Milan, Italy

    Carmen Maccagnano

  2. Department of Urology, Humanitas Research Hospital IRCCS, Rozzano, MI, Italy

    Rodolfo Hurle

  3. Department of Sexual Medical Center, San Raffaele Hospital, Milano, Italy

    Elena Vittoria Longhi

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  1. Carmen Maccagnano
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  2. Rodolfo Hurle
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  3. Elena Vittoria Longhi
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Editors and Affiliations

  1. Department of Sexual Medical Center, San Raffaele Hospital, Milano, Italy

    Elena Vittoria Longhi

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Maccagnano, C., Hurle, R., Longhi, E.V. (2023). Interstitial Cystitis/Bladder Pain Syndrome. In: Longhi, E.V. (eds) Managing Psychosexual Consequences in Chronic Diseases. Springer, Cham. https://doi.org/10.1007/978-3-031-31307-3_40

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  • DOI: https://doi.org/10.1007/978-3-031-31307-3_40

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