Skip to main content

Lung Ultrasound in Pneumonia Diagnosis

  • Chapter
  • First Online:
Cardiopulmonary Point of Care Ultrasound

Abstract

Interest in lung ultrasound (LUS) has been growing over time, thanks also to the COVID-19 outbreak. Clinical aspects such as fever, cough and purulent sputum are fundamental for diagnosing pneumonia, along with laboratory exams (leucocytosis and procalcitonin elevation). An imaging technique is however required for diagnosis, and the gold standard has been represented for a long time by a chest X-ray (CXR) or a CT scan. Nevertheless, LUS is useful in diagnosis, monitoring of the response to therapy and follow up. These features have demonstrated to be very useful in various settings, such as emergency departments, wards and intensive care units. Multiple scanning protocols of the thorax have been proposed; at the moment, the most advantageous in terms of diagnostic accuracy and time-consume is the one considering six scanning fields for each side. POCUS findings correspond to anatomo-pathologic modifications found in pneumonia. Among the most common POCUS signs we found B lines, pleural abnormalities (thickness and irregularity), meta-pneumonic effusions and consolidations with either static or dynamic air bronchogram. For what concerns assessment and follow up of the severity of illness, it is useful to adopt the lung ultrasound aeration score, assigning a score from 0 to 3 for each field explored; the sum of the points obtained ranges from 0 to 36 (see chapter for more details). During the pandemic era LUS has been very useful for mass screening of patients attending the emergency departments allowing identification of potentially positive patients, even if the findings were not illness-specific. For this reason, usefulness of LUS for COVID-19 diagnosis will need to be re-evaluated at the end of the pandemic.

If you don’t look, you won’t know!

Anonymous

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

BLUE:

Bedside Lung Ultrasound in Emergency

CAD:

Computer aided diagnosis

CAP:

Community Acquired Pneumonia

COVID 19:

Coronavirus Disease 19

CT:

Computed tomography

CXR:

Chest x-ray

ED:

Emergency department

ICU:

Intensive care unit

LUS:

Lung Ultrasound

PCT:

Procalcitonin

POCUS:

Point of care ultrasound

PSI:

Pneumonia severity index

VAP:

Ventilator Associated Pneumonia

References

  1. WHO|Revised Global Burden of Disease (GBD) estimates [Internet]. 2002. https://www.who.int/healthinfo/global_burden_disease/estimates_regional_2002_revised/en/. Accessed 10 Feb 2021

  2. Noguchi S, Yatera K, Kawanami T, Fujino Y, Moro H, Aoki N, et al. Pneumonia severity assessment tools for predicting mortality in patients with healthcare-associated pneumonia: a systematic review and meta-analysis. Respiration [Internet]. 2017;93(6):441–50. https://www.karger.com/Article/FullText/470915. Accessed 7 Feb 2021

  3. Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, et al. Diagnosis and treatment of adults with community-acquired pneumonia. Am J Respir Crit Care Med [Internet]. 2019;200(7):E45–67. https://doi.org/10.1164/rccm.201908-1581ST. Accessed 7 Feb 2021

  4. Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, et al. Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the management of community-acquired pneumonia in adults [Internet]. Vol. 44, Clinical Infectious Diseases. Clin Infect Dis; 2007. https://pubmed.ncbi.nlm.nih.gov/17278083/. Accessed 12 Jan 2021

  5. Torres A, Niederman MS, Chastre J, Ewig S, Fernandez-Vandellos P, Hanberger H, et al. International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia [Internet]. Vol. 50, European Respiratory Journal. European Respiratory Society; 2017. p. 1700582. http://ow.ly/dGhv30dAVoa. Accessed 9 Feb 2021

  6. Franquet T. Imaging of Community-Acquired Pneumonia. In: Journal of Thoracic Imaging [Internet]. Lippincott Williams and Wilkins; 2018. p. 282–94. https://pubmed.ncbi.nlm.nih.gov/30036297/. Accessed 8 Jan 2021

  7. Corradi F, Brusasco C, Garlaschi A, Paparo F, Ball L, Santori G, et al. Quantitative analysis of lung ultrasonography for the detection of community-acquired pneumonia: A pilot study. Biomed Res Int [Internet]. 2015;2015. https://pubmed.ncbi.nlm.nih.gov/25811032/. Accessed 7 Feb 2021

  8. Lichtenstein DA, Mezière GA. Relevance of lung ultrasound in the diagnosis of acute respiratory failure the BLUE protocol. Chest [Internet]. 2008;134(1):117–25. https://pubmed.ncbi.nlm.nih.gov/18403664/. Accessed 12 Jan 2021

  9. Silvia Mongodi A, Bouhemad B, Orlando A, Stella A, Tavazzi G, Via G, et al. Modified Lung Ultrasound Score for Assessing and Monitoring Pulmonary Aeration Modifizierter Lungen-US-Score zur Bewertung und Überwachung der Belüftung der Lunge. Modif Lung Ultrasound Ultraschall Med [Internet]. 2017;37:530–7. https://doi.org/10.1055/s-0042-120260. Accessed 8 Feb 2021

  10. Chiumello D, Mongodi S, Algieri I, LucaVergani G, Orlando A, Via G, et al. Assessment of lung aeration and recruitment by CT scan and ultrasound in acute respiratory distress syndrome patients. Crit Care Med [Internet]. 2018;46(11):1761–8. https://pubmed.ncbi.nlm.nih.gov/30048331/. Accessed 8 Feb 2021

  11. Corradi F, Brusasco C, Vezzani A, Santori G, Manca T, Ball L, et al. Computer-Aided Quantitative Ultrasonography for Detection of Pulmonary Edema in Mechanically Ventilated Cardiac Surgery Patients. Chest [Internet]. 2016;150(3):640–51. https://doi.org/10.1016/j.chest.2016.04.013

  12. Corradi F, Ball L, Brusasco C, Riccio AM, Baroffio M, Bovio G, et al. Assessment of extravascular lung water by quantitative ultrasound and CT in isolated bovine lung. Respir Physiol Neurobiol [Internet]. 2013;187(3):244–9. https://pubmed.ncbi.nlm.nih.gov/23584050/. Accessed 19 Mar 2021

  13. Reissig A, Copetti R, Mathis G, Mempel C, Schuler A, Zechner P, et al. Lung ultrasound in the diagnosis and follow-up of community-acquired pneumonia: A prospective, multicenter, diagnostic accuracy study. Chest. 2012;142(4):965–72.

    Article  PubMed  Google Scholar 

  14. Cortellaro F, Colombo S, Coen D, Duca PG. Lung ultrasound is an accurate diagnostic tool for the diagnosis of pneumonia in the emergency department. Emerg Med J [Internet]. 2012;29(1):19–23. https://pubmed.ncbi.nlm.nih.gov/21030550/. Accessed 12 Jan 2021

  15. Laursen CB, Sloth E, Lassen AT, Christensen R de P, Lambrechtsen J, Madsen PH, et al. Point-of-care ultrasonography in patients admitted with respiratory symptoms: A single-blind, randomised controlled trial. Lancet Respir Med [Internet]. 2014;2(8):638–46. https://pubmed.ncbi.nlm.nih.gov/24998674/. Accessed 19 Mar 2021

  16. Ye X, Xiao H, Chen B, Zhang S. Accuracy of Lung Ultrasonography versus Chest Radiography for the Diagnosis of Adult Community-Acquired Pneumonia: Review of the Literature and Meta-Analysis. Chalmers JD, editor. PLoS One [Internet]. 2015;10(6):e0130066. https://doi.org/10.1371/journal.pone.0130066. Accessed 19 Mar 2021

  17. Reissig A, Gramegna A, Aliberti S. The role of lung ultrasound in the diagnosis and follow-up of community-acquired pneumonia. Eur J Intern Med [Internet]. 2012;23(5):391–7. https://doi.org/10.1016/j.ejim.2012.01.003

  18. Nazerian P, Volpicelli G, Vanni S, Gigli C, Betti L, Bartolucci M, et al. Accuracy of lung ultrasound for the diagnosis of consolidations when compared to chest computed tomography. Am J Emerg Med [Internet]. 2015;33(5):620–5. https://pubmed.ncbi.nlm.nih.gov/25758182/. Accessed 13 Jan 2021

  19. Lichtenstein DA, Lascols N, Mezière G, Gepner A. Ultrasound diagnosis of alveolar consolidation in the critically ill. Intensive Care Med [Internet]. 2004;30(2):276–81. https://pubmed.ncbi.nlm.nih.gov/14722643/. Accessed 11 Feb 2021

  20. Mateos González M, García de Casasola Sánchez G, Muñoz FJT, Proud K, Lourdo D, Sander J-V, et al. Comparison of Lung Ultrasound versus Chest X-ray for Detection of Pulmonary Infiltrates in COVID-19. Diagnostics (Basel, Switzerland) [Internet]. 2021;11(2). http://www.ncbi.nlm.nih.gov/pubmed/33671699. Accessed 19 Mar 2021

  21. Mayo PH, Copetti R, Feller-Kopman D, Mathis G, Maury E, Mongodi S, et al. Thoracic ultrasonography: a narrative review [Internet]. Vol. 45, Intensive Care Medicine. Springer Verlag; 2019. p. 1200–11. https://doi.org/10.1007/s00134-019-05725-8. Accessed 8 Jan 2021

  22. Zagli G, Cozzolino M, Terreni A, Biagioli T, Caldini AL, Peris A. Diagnosis of Ventilator-Associated Pneumonia: A Pilot, Exploratory Analysis of a New Score Based on Procalcitonin and Chest Echography. Chest [Internet]. 2014;146(6):1578–85. https://pubmed.ncbi.nlm.nih.gov/25144666/. Accessed 14 Feb 2021

  23. Lichtenstein D, Mezière G. A lung ultrasound sign allowing bedside distinction between pulmonary edema and COPD: The comet-tail artifact. Intensive Care Med [Internet]. 1998;24(12):1331–4. https://pubmed.ncbi.nlm.nih.gov/9885889/. Accessed 19 Mar 2021

  24. Volpicelli G, Elbarbary M, Blaivas M, Lichtenstein DA, Mathis G, Kirkpatrick AW, et al. International evidence-based recommendations for point-of-care lung ultrasound. In: Intensive Care Medicine [Internet]. Springer; 2012. p. 577–91. https://doi.org/10.1007/s00134-012-2513-4. Accessed 13 Jan 2021

  25. Volpicelli G, Mussa A, Garofalo G, Cardinale L, Casoli G, Perotto F, et al. Bedside lung ultrasound in the assessment of alveolar-interstitial syndrome. Am J Emerg Med [Internet]. 2006;24(6):689–96. https://pubmed.ncbi.nlm.nih.gov/16984837/. Accessed 19 Mar 2021

  26. Mongodi S, Via G, Girard M, Rouquette I, Misset B, Braschi A, et al. Lung ultrasound for early diagnosis of ventilator-associated pneumonia. Chest [Internet]. 2016;149(4):969–80. https://doi.org/10.1016/j.chest.2015.12.012

  27. Soummer A, Perbet S, Brisson H, Arbelot C, Constantin JM, Lu Q, et al. Ultrasound assessment of lung aeration loss during a successful weaning trial predicts postextubation distress. Crit Care Med [Internet]. 2012;40(7):2064–72. https://pubmed.ncbi.nlm.nih.gov/22584759/. Accessed 19 Mar 2021

  28. Mojoli F, Bouhemad B, Mongodi S, Lichtenstein D. Lung ultrasound for critically ill patients. Am J Respir Crit Care Med. 2019;199(6):701–14.

    Article  PubMed  Google Scholar 

  29. Volpicelli G, Lamorte A, Villén T. What’s new in lung ultrasound during the COVID-19 pandemic. Intensive Care Med [Internet]. 2020;46(7):1445–8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196717/. Accessed 21 Jan 2021

  30. Rouby JJ, Arbelot C, Gao Y, Zhang M, Lv J, An Y, et al. Training for lung ultrasound score measurement in critically ill patients [Internet]. Vol. 198, Am J Respir Critical Care Med. American Thoracic Society; 2018. p. 398–401. https://doi.org/10.1164/rccm.201802-0227LE. Accessed 19 Mar 2021

  31. Ball L, Corradi F, Pelosi P. Ultrasonography in Critical Care Medicine: The WAMS Approach. ICU Manag Pract [Internet]. 2012;12(2):30–3. https://healthmanagement.org/c/icu/issuearticle/ultrasonography-in-critical-care-medicine-the-wams-approach

  32. Kumar V, Abbas A, Aster J. Robbins & Cotran Pathologic Basis of Disease [Internet]. 10th ed. 2020. 1392 https://www.elsevier.com/books/robbins-and-cotran-pathologic-basis-of-disease/kumar/978-0-323-53113-9

  33. Ware LB, Matthay MA. The Acute Respiratory Distress Syndrome. N Engl J Med [Internet]. 2000;342(18):1334–49. https://doi.org/10.1056/NEJM200005043421806. Accessed 19 Mar 2021

  34. Lichtenstein D, Mézière G, Biderman P, Gepner A, Barré O. The comet-tail artifact: An ultrasound sign of alveolar-interstitial syndrome. Am J Respir Crit Care Med. 1997;156(5):1640–6.

    Article  CAS  PubMed  Google Scholar 

  35. Reissig A, Kroegel C. Sonographic diagnosis and follow-up of pneumonia: A prospective study. Respiration. 2007;74(5):537–47.

    Article  PubMed  Google Scholar 

  36. Lichtenstein D, Mezière G, Seitz J. The dynamic air bronchogram: A lung ultrasound sign of alveolar consolidation ruling out atelectasis. Chest. 2009;135(6):1421–5.

    Article  PubMed  Google Scholar 

  37. Asano M, Watanabe H, Sato K, Okuda Y, Sakamoto S, Hasegawa Y, et al. Validity of ultrasound lungcomets for assessment of the severity of interstitial pneumonia. J Ultrasound Med [Internet]. 2018;37(6):1523–31. https://pubmed.ncbi.nlm.nih.gov/29194717/. Accessed 13 Jan 2021

  38. WHO Coronavirus Disease (COVID-19) Dashboard [Internet]. https://covid19.who.int/?gclid=CjwKCAiAmrOBBhA0EiwArn3mfCJKUEDBXkdjAKKQZ1bvekFSiEwZrJnF2O_K1SJhy_2ampQQBKPtcRoC2RMQAvD_BwE. Accessed 17 Feb 2021

  39. Gargani L, Soliman-Aboumarie H, Volpicelli G, Corradi F, Pastore MC, Cameli M. Why, when, and how to use lung ultrasound during the COVID-19 pandemic: Enthusiasm and caution [Internet]. Vol. 21, Eur Heart J Cardiovasc Imaging. Oxford University Press; 2020. p. 941–8. https://pubmed.ncbi.nlm.nih.gov/32515793/. Accessed 13 Jan 2021

  40. Gattinoni L, Chiumello D, Caironi P, Busana M, Romitti F, Brazzi L, et al. COVID-19 pneumonia: different respiratory treatments for different phenotypes? [Internet]. Vol. 46, Intensive Care Medicine. Springer; 2020. p. 1099–102. https://pubmed.ncbi.nlm.nih.gov/32291463/. Accessed 17 Feb 2021

  41. Guarracino F, Vetrugno L, Forfori F, Corradi F, Orso D, Bertini P, et al. Lung, heart, vascular, and diaphragm ultrasound examination of COVID-19 patients: a comprehensive approach [Internet]. J Cardiothorac Vasc Anesth. W.B. Saunders; 2020;35(6):1866–1874. Accessed 7 Feb 2021

    Google Scholar 

  42. Gargani L, Soliman-Aboumarie H, Volpicelli G, Corradi F, Pastore MC, Cameli M. Why, when, and how to use lung ultrasound during the COVID-19 pandemic: enthusiasm and caution. Eur Heart J Cardiovasc Imaging [Internet]. 2020;21(9):941–8. https://academic.oup.com/ehjcimaging/article/21/9/941/5855021

  43. Hussain A, Via G, Melniker L, Goffi A, Tavazzi G, Neri L, et al. Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus [Internet]. Vol. 24, Critical Care. BioMed Central Ltd; 2020. https://pubmed.ncbi.nlm.nih.gov/33357240/. Accessed 21 Mar 2021

  44. Volpicelli G, Gargani L. Sonographic signs and patterns of COVID-19 pneumonia. Ultrasound J [Internet]. 2020;12(1):22. https://doi.org/10.1186/s13089-020-00171-w. Accessed 21 Jan 2021

  45. Bouhemad B, Liu ZH, Arbelot C, Zhang M, Ferarri F, Le-Guen M, et al. Ultrasound assessment of antibiotic-induced pulmonary reaeration in ventilator-associated pneumonia. Crit Care Med [Internet]. 2010;38(1):84–92. https://pubmed.ncbi.nlm.nih.gov/19633538/. Accessed 9 Feb 2021

  46. Mongodi S, Santangelo E, De Luca D, Rovida S, Corradi F, Volpicelli G, et al. Quantitative Lung Ultrasound: Time for a Consensus? [Internet]. Vol. 158, Chest. Elsevier Inc; 2020. p. 469–70. https://pubmed.ncbi.nlm.nih.gov/32768066/. Accessed 11 Jan 2021

  47. Brusasco C, Santori G, Tavazzi G, Via G, Robba C, Gargani L, et al. Second-order grey-scale texture analysis of pleural ultrasound images to differentiate acute respiratory distress syndrome and cardiogenic pulmonary edema. J Clin Monit Comput [Internet]. 2020. https://pubmed.ncbi.nlm.nih.gov/33313979/. Accessed 21 Mar 2021

  48. Corradi F, Via G, Forfori F, Brusasco C, Tavazzi G. Lung ultrasound and B-lines quantification inaccuracy: B sure to have the right solution [Internet]. Vol. 46, Intensive Care Medicine. Springer; 2020. p. 1081–3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087507/. Accessed 7 Feb 2021

  49. Brusasco C, Santori G, Bruzzo E, Trò R, Robba C, Tavazzi G, et al. Quantitative lung ultrasonography: a putative new algorithm for automatic detection and quantification of B-lines. Crit Care [Internet]. 2019;23(1):288. https://doi.org/10.1186/s13054-019-2569-4. Accessed 7 Feb 2021

  50. Corradi F, Brusasco C, Brusasco V. Cuándo, dónde y cómo utilizar la ecografía en pacientes con enfermedad pulmonar obstructiva crónica? Arch Bronconeumol [Internet]. 2017;53(5):229–30. https://pubmed.ncbi.nlm.nih.gov/28024665/. Accessed 11 Jan 2021

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Francesco Corradi .

Editor information

Editors and Affiliations

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary file1 (MP4 876 kb)

Supplementary file2 (MP4 2024 kb)

Supplementary file3 (MP4 897 kb)

Supplementary file4 (MP4 846 kb)

Supplementary file5 (MP4 1938 kb)

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Corradi, F., Forfori, F., Cucciolini, G., Trunfio, D. (2023). Lung Ultrasound in Pneumonia Diagnosis. In: Soliman-Aboumarie, H., Haertel Miglioranza, M., Gargani, L., Volpicelli, G. (eds) Cardiopulmonary Point of Care Ultrasound. Springer, Cham. https://doi.org/10.1007/978-3-031-29472-3_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-29472-3_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-29471-6

  • Online ISBN: 978-3-031-29472-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics