Abstract
Anomalies of the coronary arteries are paradoxically among the simplest and yet most difficult of subjects to understand in congenital heart disease. Disconcertingly, even the definition of what constitutes an “anomalous” vessel has been disputed in the past. In this chapter we discuss the definition and clinical presentation of common coronary anomalies. We take a look at the use of imaging, particular cardiovascular magentic resonance imaging, for understanding the significance and clinical impact of anomalies and make the case for a direct link between imaging findings and subsequent medical and surgical decision making.
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References
Brothers J, Gaynor JW, Paridon S, Lorber R, Jacobs M. Anomalous aortic origin of a coronary artery with an interarterial course: understanding current management strategies in children and young adults. Pediatr Cardiol. 2009;30(7):911–21.
Cheitlin MD, De Castro CM, McAllister HA. Sudden death as a complication of anomalous left coronary origin from the anterior sinus of valsalva, A not-so-minor congenital anomaly. Circulation. 1974;50(4):780–7.
Cheitlin MD. Finding asymptomatic people with a coronary artery arising from the wrong sinus of valsalva: consequences arising from knowing the anomaly to be familial. J Am Coll Cardiol. 2008;51(21):2065–7.
Boon B. Leonardo da vinci on atherosclerosis and the function of the sinuses of valsalva. Neth Heart J. 2009;17(12):496–9.
Morgagni G. The seats and causes of diseases investigated by anatomy; in five books,: Containing A great variety of dissections, with remarks. to which are added very accurate and copious indexes of the principal things and names therein contained. translated from the latin of john baptist morgagni, chief professor of anatomy, and president of the university at padua, by benjamin alexander, M. D. in three volumes. ... . London: printed for A. Millar; and T. Cadell.
Angelini P. Normal and anomalous coronary arteries: definitions and classification. Am Heart J. 1989;117(2):418–34.
Jacobs ML, Mavroudis C. Anomalies of the coronary arteries: nomenclature and classification. Cardiol Young. 2010;20(Suppl 3):15–9.
Anderson RH, Spicer D. Fistulous communications with the coronary arteries in the setting of hypoplastic ventricles. Cardiol Young. 2010 Dec;20(Suppl 3):86–91.
Angelini P, Fairchild VD, editors. Coronary artery anomalies: a comprehensive approach. Philadelphia: Lippincott Williams & Wilkins; 1999.
Brothers JA, Gaynor JW, Jacobs JP, Caldarone C, Jegatheeswaran A, Jacobs ML, et al. The registry of anomalous aortic origin of the coronary artery of the congenital heart surgeons’ society. Cardiol Young. 2010;20(Suppl 3):50–8.
Gawor R, Kusmierek J, Plachcinska A, Bienkiewicz M, Drozdz J, Piotrowski G, et al. Myocardial perfusion GSPECT imaging in patients with myocardial bridging. J Nucl Cardiol. 2011;18(6):1059–65.
Hakeem A, Cilingiroglu M, Leesar MA. Hemodynamic and intravascular ultrasound assessment of myocardial bridging: fractional flow reserve paradox with dobutamine versus adenosine. Catheter Cardiovasc Interv. 2010;75(2):229–36.
Thiene G, Carturan E, Corrado D, Basso C. Prevention of sudden cardiac death in the young and in athletes: dream or reality? Cardiovasc Pathol. 2010;19(4):207–17.
Maron BJ, Doerer JJ, Haas TS, Tierney DM, Mueller FO. Sudden deaths in young competitive athletes: analysis of 1866 deaths in the United States, 1980-2006. Circulation. 2009;119(8):1085–92.
Eckart RE, Scoville SL, Campbell CL, Shry EA, Stajduhar KC, Potter RN, et al. Sudden death in young adults: a 25-year review of autopsies in military recruits. Ann Intern Med. 2004;141(11):829–34.
Hill SF, Sheppard MN. Non-atherosclerotic coronary artery disease associated with sudden cardiac death. Heart. 2010;96(14):1119–25.
Baroldi G. In: Scomazzoni G, United States, Armed Forces Institute of Pathology (U.S.), editors. Coronary circulation in the normal and the pathologic heart. Washington: Armed Forces Institute of Pathology [for sale by the Supt. of Docs.]; 1967.
Davies JE, Burkhart HM, Dearani JA, Suri RM, Phillips SD, Warnes CA, et al. Surgical management of anomalous aortic origin of a coronary artery. Ann Thorac Surg. 2009;88(3):844–7; discussion 847–8.
De Luca L, Bovenzi F, Rubini D, Niccoli-Asabella A, Rubini G, De Luca I. Stress-rest myocardial perfusion SPECT for functional assessment of coronary arteries with anomalous origin or course. J Nucl Med. 2004;45(4):532–6.
Yamanaka O, Hobbs RE. Coronary artery anomalies in 126,595 patients undergoing coronary arteriography. Catheter Cardiovasc Diagn. 1990;21(1):28–40.
Zhang LJ, Yang GF, Huang W, Zhou CS, Chen P, Lu GM. Incidence of anomalous origin of coronary artery in 1879 chinese adults on dual-source CT angiography. Neth Heart J. 2010;18(10):466–70.
Angelini P, Flamm SD. Newer concepts for imaging anomalous aortic origin of the coronary arteries in adults. Catheter Cardiovasc Interv. 2007;69(7):942–54.
Crean AM, Kilcullen N, Younger JF. Arrhythmic acute coronary syndrome and anomalous left main stem artery: culprit or innocent bystander. Acute Card Care. 2008;10(1):60–1.
McConnell MV, Ganz P, Selwyn AP, Li W, Edelman RR, Manning WJ. Identification of anomalous coronary arteries and their anatomic course by magnetic resonance coronary angiography. Circulation. 1995;92(11):3158–62.
Post JC, van Rossum AC, Hofman MB, Valk J, Visser CA. Protocol for two-dimensional magnetic resonance coronary angiography studied in three-dimensional magnetic resonance data sets. Am Heart J. 1995;130(1):167–73.
Vliegen HW, Doornbos J, de Roos A, Jukema JW, Bekedam MA, van der Wall EE. Value of fast gradient echo magnetic resonance angiography as an adjunct to coronary arteriography in detecting and confirming the course of clinically significant coronary artery anomalies. Am J Cardiol. 1997;79(6):773–6.
Bekedam MA, Vliegen HW, Doornbos J, Jukema JW, de Roos A, van der Wall EE. Diagnosis and management of anomalous origin of the right coronary artery from the left coronary sinus. Int J Card Imaging. 1999;15(3):253–8.
White CS, Laskey WK, Stafford JL, NessAiver M. Coronary MRA: use in assessing anomalies of coronary artery origin. J Comput Assist Tomogr. 1999;23(2):203–7.
Taylor AM, Thorne SA, Rubens MB, Jhooti P, Keegan J, Gatehouse PD, et al. Coronary artery imaging in grown up congenital heart disease: complementary role of magnetic resonance and x-ray coronary angiography. Circulation. 2000;101(14):1670–8.
Greil GF, Stuber M, Botnar RM, Kissinger KV, Geva T, Newburger JW, et al. Coronary magnetic resonance angiography in adolescents and young adults with Kawasaki disease. Circulation. 2002;105(8):908–11.
Bunce NH, Lorenz CH, Keegan J, Lesser J, Reyes EM, Firmin DN, et al. Coronary artery anomalies: assessment with free-breathing three-dimensional coronary MR angiography. Radiology. 2003;227(1):201–8.
Mavrogeni S, Papadopoulos G, Douskou M, Kaklis S, Seimenis I, Baras P, et al. Magnetic resonance angiography is equivalent to X-ray coronary angiography for the evaluation of coronary arteries in Kawasaki disease. J Am Coll Cardiol. 2004;43(4):649–52.
Su JT, Chung T, Muthupillai R, Pignatelli RH, Kung GC, Diaz LK, et al. Usefulness of real-time navigator magnetic resonance imaging for evaluating coronary artery origins in pediatric patients. Am J Cardiol. 2005;95(5):679–82.
Taylor AM, Dymarkowski S, Hamaekers P, Razavi R, Gewillig M, Mertens L, et al. MR coronary angiography and late-enhancement myocardial MR in children who underwent arterial switch surgery for transposition of great arteries. Radiology. 2005;234(2):542–7.
Takemura A, Suzuki A, Inaba R, Sonobe T, Tsuchiya K, Omuro M, et al. Utility of coronary MR angiography in children with Kawasaki disease. AJR Am J Roentgenol. 2007;188(6):W534–9.
Gharib AM, Ho VB, Rosing DR, Herzka DA, Stuber M, Arai AE, et al. Coronary artery anomalies and variants: technical feasibility of assessment with coronary MR angiography at 3 T. Radiology. 2008;247(1):220–7.
Beerbaum P, Sarikouch S, Laser KT, Greil G, Burchert W, Korperich H. Coronary anomalies assessed by whole-heart isotropic 3D magnetic resonance imaging for cardiac morphology in congenital heart disease. J Magn Reson Imaging. 2009;29(2):320–7.
Clemente A, Del Borrello M, Greco P, Mannella P, Di Gregorio F, Romano S, et al. Anomalous origin of the coronary arteries in children: diagnostic role of three-dimensional coronary MR angiography. Clin Imaging. 2010;34(5):337–43.
Tangcharoen T, Bell A, Hegde S, Hussain T, Beerbaum P, Schaeffter T, et al. Detection of coronary artery anomalies in infants and young children with congenital heart disease by using MR imaging. Radiology. 2011;259(1):240–7.
Rajiah P, Setser RM, Desai MY, Flamm SD, Arruda JL. Utility of free-breathing, whole-heart, three-dimensional magnetic resonance imaging in the assessment of coronary anatomy for congenital heart disease. Pediatr Cardiol. 2011;32(4):418–25.
Gui D, Tsekos NV. Dynamic imaging of contrast-enhanced coronary vessels with a magnetization prepared rotated stripe keyhole acquisition. J Magn Reson Imaging. 2007;25(1):222–30.
Nakamura M, Kido T, Kido T, Watanabe K, Schmidt M, Forman C, Mochizuki T. Non-contrast compressed sensing whole-heart coronary magnetic resonance angiography at 3T: a comparison with conventional imaging. Eur J Radiol. 2018;104:43–8. https://doi.org/10.1016/j.ejrad.2018.04.025; Epub 2018 Apr 27.
Hirai K, Kido T, Kido T, Ogawa R, Tanabe Y, Nakamura M, Kawaguchi N, Kurata A, Watanabe K, Yamaguchi O, Schmidt M, Forman C, Mochizuki T. Feasibility of contrast-enhanced coronary artery magnetic resonance angiography using compressed sensing. J Cardiovasc Magn Reson. 2020;22(1):15. https://doi.org/10.1186/s12968-020-0601-0.
Ishida M, Schuster A, Takase S, Morton G, Chiribiri A, Bigalke B, Schaeffter T, Sakuma H, Nagel E. Impact of an abdominal belt on breathing patterns and scan efficiency in whole-heart coronary magnetic resonance angiography: comparison between the UK and Japan. J Cardiovasc Magn Reson. 2011;13(1):71. https://doi.org/10.1186/1532-429X-13-71.
Ishida M, Schuster A, Takase S, Morton G, Chiribiri A, Bigalke B, et al. Impact of an abdominal belt on breathing patterns and scan efficiency in whole-heart coronary magnetic resonance angiography: comparison between the UK and Japan. J Cardiovasc Magn Reson. 2011;13:71.
Tobler D, Motwani M, Wald RM, Roche SL, Verocai F, Iwanochko RM, Greenwood JP, Oechslin EN, Crean AM. Evaluation of a comprehensive cardiovascular magnetic resonance protocol in young adults late after the arterial switch operation for d-transposition of the great arteries. J Cardiovasc Magn Reson. 2014;16(1):98. https://doi.org/10.1186/s12968-014-0098-5.
Deva DP, Torres FS, Wald RM, Roche SL, Jimenez-Juan L, Oechslin EN, Crean AM. The value of stress perfusion cardiovascular magnetic resonance imaging for patients referred from the adult congenital heart disease clinic: 5-year experience at the Toronto General Hospital. Cardiol Young. 2014;24(5):822–30. https://doi.org/10.1017/S104795111300111X; Epub 2013 Sep 18.
Laflamme E, Alonso-Gonzalez R, Roche SL, Wald RM, Swan L, Silversides CK, Thorne SA, Horlick EM, Benson LN, Osten M, Hickey E, Barron DJ, Colman JM, Oechslin E, Crean AM. Anomalous origin of a coronary artery from the pulmonary artery presenting in adulthood: experience from a tertiary center. Int J Cardiol Congenit Heart Dis. 2021;4:100169. https://doi.org/10.1016/j.ijcchd.2021.100169.
Fratz S, Chung T, Greil GF, Samyn MM, Taylor AM, Valsangiacomo Buechel ER, Yoo SJ, Powell AJ. Guidelines and protocols for cardiovascular magnetic resonance in children and adults with congenital heart disease: SCMR expert consensus group on congenital heart disease. J Cardiovasc Magn Reson. 2013;15(1):51. https://doi.org/10.1186/1532-429X-15-51.
Strigl S, Beroukhim R, Valente AM, Annese D, Harrington JS, Geva T, et al. Feasibility of dobutamine stress cardiovascular magnetic resonance imaging in children. J Magn Reson Imaging. 2009;29(2):313–9.
Song L, Ma X, Zhao X, Zhao L, DeLano M, Fan Y, Wu B, Lu A, Tian J, He L. Validation of black blood late gadolinium enhancement (LGE) for evaluation of myocardial infarction in patients with or without pathological Q-wave on electrocardiogram (ECG). Cardiovasc Diagn Ther. 2020;10(2):124–34. https://doi.org/10.21037/cdt.2019.12.11.
Backer CL, Stout MJ, Zales VR, Muster AJ, Weigel TJ, Idriss FS, et al. Anomalous origin of the left coronary artery. A twenty-year review of surgical management. J Thorac Cardiovasc Surg. 1992;103(6):1049–57; discussion 1057–8.
Belli E, Roussin R, Ly M, Roubertie F, Le Bret E, Basaran M, et al. Anomalous origin of the left coronary artery from the pulmonary artery associated with severe left ventricular dysfunction: results in normothermia. Ann Thorac Surg. 2010;90(3):856–60.
Ben Ali W, Metton O, Roubertie F, Pouard P, Sidi D, Raisky O, et al. Anomalous origin of the left coronary artery from the pulmonary artery: late results with special attention to the mitral valve. Eur J Cardiothorac Surg. 2009;36(2):244–8; discussion 248–9.
Karunadasa R, Buxton BF, Dick R, Calafiore P. Anomalous origin of left coronary artery from the pulmonary artery does the management in the adult differ from that of the infant? Four cases of the bland-white-garland syndrome. Heart Lung Circ. 2007;16(Suppl 3):S29–33.
Mavroudis C, Dodge-Khatami A, Stewart RD, Jacobs ML, Backer CL, Lorber RE. An overview of surgery options for congenital coronary artery anomalies. Futur Cardiol. 2010;6(5):627–45.
Wintersperger BJ, von Smekal A, Engelmann MG, Knez A, Penzkofer HV, Laub G, et al. Contrast media enhanced magnetic resonance angiography for determining patency of a coronary bypass. A comparison with coronary angiography. Rofo. 1997;167(6):572–8.
Brenner P, Wintersperger B, von Smekal A, Agirov V, Bohm D, Kreuzer E, et al. Detection of coronary artery bypass graft patency by contrast enhanced magnetic resonance angiography. Eur J Cardiothorac Surg. 1999;15(4):389–93.
Bunce NH, Lorenz CH, John AS, Lesser JR, Mohiaddin RH, Pennell DJ. Coronary artery bypass graft patency: assessment with true ast imaging with steady-state precession versus gadolinium-enhanced MR angiography. Radiology. 2003;227(2):440–6.
Manso B, Castellote A, Dos L, Casaldaliga J. Myocardial perfusion magnetic resonance imaging for detecting coronary function anomalies in asymptomatic paediatric patients with a previous arterial switch operation for the transposition of great arteries. Cardiol Young. 2010;20(4):410–7.
https://www.sciencedirect.com/science/article/pii/S2666668521000938.
Schmitt R, Froehner S, Brunn J, Wagner M, Brunner H, Cherevatyy O, et al. Congenital anomalies of the coronary arteries: imaging with contrast-enhanced, multidetector computed tomography. Eur Radiol. 2005;15(6):1110–21.
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16.1 Electronic Supplementary Materials
Movie 16.1
Axial whole heart magnetic resonance angiogram depicting the quality of coronary imaging that can be routinely achieved by CMR.
Movie 16.2
Coronal steady state free precession single shot coronal images acquired in quiet respiration for planning of a respiratory navigator sequence
Movie 16.3
4 chamber steady state free precession cine image acquired with a standard temporal resolution of 35-50 msec and reconstructed in 20 frames.
Movie 16.4
4 chamber steady state free precession cine image acquired with a high temporal resolution of 10 msec and reconstructed in 80 frames.
Movie 16.5
Dynamic cardiac CT maximum intensity projection coronal slab demonstrating direct compression of the left main and proximal left anterior descending coronary arteries during cardiac systole.
Movie 16.6
Full volume dynamic maximum intensity projection reconstruction of a gated cardiac CT in a patient with an anomalous right coronary artery from the pulmonary artery (ARCAPA).
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Crean, A. (2023). Coronary Artery Anomalies. In: Syed, M.A., Mohiaddin, R.H. (eds) Magnetic Resonance Imaging of Congenital Heart Disease. Springer, Cham. https://doi.org/10.1007/978-3-031-29235-4_16
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