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Axonal Transport Defects in Retinal Ganglion Cell Diseases

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Retinal Degenerative Diseases XIX

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1415))

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Abstract

For the survival and maintenance of retinal ganglion cells (RGCs), axonal transportation is fundamental. Axonal transportation defects can cause severe neuropathies leading to neuronal loss. Axonal transport defects usually precede axonal degeneration and RGC loss in disease models. To date, the main causes of axonal transport defects have not been fully understood. Therefore, elucidation of the mechanisms that lead to transport defects will help us to develop novel therapeutic targets and early diagnostic tools. In this review, we provide an overview of optic neuropathies and axonal degeneration with a focus on axonal transport.

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Abbreviations

ALS:

Amyotrophic lateral sclerosis

ATP:

Adenine triphosphate

CTB:

Cholera toxin B

GC:

Glucocorticoid

DEX:

Dexamethasone-21-acetate

DOA:

Dominant optic atrophy

IOP:

Intraocular pressure

LGN:

Lateral geniculate nucleus

LHON:

Leber’s hereditary optic neuropathy

NMDA:

N-methyly-D-aspartate 

OPA 1:

Optic atrophy 1

POAG:

Primary open-angle glaucoma

RNFL:

Retinal nerve fiber layer

RGC:

Retinal ganglion cell

SC:

Superior colliculus

TEM:

Transmission electron microscopy

TTc:

Tetanus toxin

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Author information

Authors and Affiliations

  1. Molecular Biology, Genetics and Bioengineering Program, Sabanci University, Istanbul, Turkey

    Iskalen Cansu Topcu Okan, Fatma Ozdemir & Cavit Agca

  2. Nanotechnology Research and Application Center (SUNUM), Sabanci University, Istanbul, Turkey

    Cavit Agca

Authors
  1. Iskalen Cansu Topcu Okan
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  2. Fatma Ozdemir
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  3. Cavit Agca
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Corresponding author

Correspondence to Cavit Agca .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    John D. Ash

  2. Ocular Genomics InstituteDepartment of OphthalmologyMassachusetts Eye and Ear InfirmaryHarvard Medical School, Boston, MA, USA

    Eric Pierce

  3. Health Sciences Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Robert E. Anderson

  4. Department of Ophthalmology, Duke Medical Center, Durham, NC, USA

    Catherine Bowes Rickman

  5. Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA

    Joe G. Hollyfield

  6. Laboratory for Retinal Cell BiologyDepartment of OphthalmologyUniversity Hospital Zurich, University of Zurich, Schlieren, Switzerland

    Christian Grimm

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Okan, I.C.T., Ozdemir, F., Agca, C. (2023). Axonal Transport Defects in Retinal Ganglion Cell Diseases. In: Ash, J.D., Pierce, E., Anderson, R.E., Bowes Rickman, C., Hollyfield, J.G., Grimm, C. (eds) Retinal Degenerative Diseases XIX. Advances in Experimental Medicine and Biology, vol 1415. Springer, Cham. https://doi.org/10.1007/978-3-031-27681-1_32

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