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Duodenum und Dünndarm: Mukosaneoplasien

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Atlas Frühkarzinome des Gastrointestinaltrakts

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Zusammenfassung

Duodenale Adenome treten bei etwa 0,5 % der oberen GI-Endoskopien auf. Sporadische ampulläre und non-ampulläre Duodenal- und Dünndarmadenome, insbesondere in Anwesenheit von niedriggradigen oder hochgradigen intraepithelialen Neoplasien, haben ein malignes Potenzial, ebenso wie neuroendokrine Tumoren (NET) und gastrointestinale stromale Tumoren (GIST). Die familiäre adenomatöse Polyposis (FAP) nähert sich einem 100 %igen Lebenszeitrisiko für Duodenaladenome und einem 40 %igen Risiko für eine fortgeschrittene adenomatöse Polyposis im Alter von 60 Jahren. Daher sollten sporadische Adenome einer endoskopischen Resektion unterzogen werden, ebenso wie multiple Adenome in der FAP, um den Spigelman-Risikoscore zu verringern und eine resektive Chirurgie zu vermeiden. Ein submukosainvasives Karzinom erfordert eine große resektive Chirurgie. Die Vielfalt der Mukosa- und Submukosaveränderungen im Dünndarm erfordert ein diagnostisches Know-how, um Läsionen mit ungünstigem Verlauf, wie Adenome, dysplastische Läsionen, maligne Lymphome, NET und GIST zu identifizieren. Die endoskopische Resektion von hochriskanten Neoplasien wird in spezialisierten endoskopischen Zentren weiterentwickelt.

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Author information

Authors and Affiliations

  1. Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

    Motohiko Kato & Naohisa Yahagi

  2. Department of Digestive Diseases, Hôpital Eduard Herriot, Lyon, France

    Thierry Ponchon

Authors
  1. Motohiko Kato
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  2. Naohisa Yahagi
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  3. Thierry Ponchon
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Corresponding author

Correspondence to Naohisa Yahagi .

Editor information

Editors and Affiliations

  1. Institute of Physiology, Paracelsus Medical University, Salzburg, Österreich

    Frieder Berr

  2. Advanced Care Center, Department of Endoscopy, Saku Central Hospital, Saku, Nagano, Japan

    Tsuneo Oyama

  3. Specialities Digestives, Hôpital Édouard-Herriot, Lyon, France

    Thierry Ponchon

  4. Cancer Center, Division of Research and Development for Minimally Invasive Treatment, Keio University Hospital, Shinjuku-ku, Tokyo, Japan

    Naohisa Yahagi

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© 2023 Der/die Autor(en), exklusiv lizenziert an Springer Nature Switzerland AG

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Kato, M., Yahagi, N., Ponchon, T. (2023). Duodenum und Dünndarm: Mukosaneoplasien. In: Berr, F., Oyama, T., Ponchon, T., Yahagi, N. (eds) Atlas Frühkarzinome des Gastrointestinaltrakts. Springer, Cham. https://doi.org/10.1007/978-3-031-25623-3_10

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  • DOI: https://doi.org/10.1007/978-3-031-25623-3_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-25622-6

  • Online ISBN: 978-3-031-25623-3

  • eBook Packages: Medicine (German Language)

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