Abstract
In the late 1980s and early 1990s, numerous observational studies noted lower rates of coronary heart disease (CHD) in women taking postmenopausal estrogen compared to women not taking postmenopausal hormone therapy. This association was noted to be strongest in women with established CHD. The Heart and Estrogen/progestin Replacement Study (HERS) Research Group attempted to answer whether there was a causal relationship between postmenopausal hormone therapy and risk of CHD.
Hulley, S., Grady, D., & Bush, T. (1998). Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women. JAMA, 280(7), 605–613. doi: 10.1001/jama.280.7.605.
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Leary, K.E. (2023). Coronary Heart Disease and HRT (HERS Trial)-1998. In: Russell, J., Skolnik, N.S. (eds) Top Articles in Primary Care. Springer, Cham. https://doi.org/10.1007/978-3-031-25620-2_73
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DOI: https://doi.org/10.1007/978-3-031-25620-2_73
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