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The Essential Role of In Vitro Maturation in Assisted Reproduction

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Hot Topics in Human Reproduction

Part of the book series: Reproductive Medicine for Clinicians ((REMECL,volume 3))

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Abstract

Although IVM previously encompassed a very narrow scope given its experimental designation, its utility as a first-line treatment choice has received renewed attention. Indeed, IVM has traditionally been reserved for women with polycystic ovarian syndrome (PCOS) and prepubertal fertility preservation prior to gonadotoxic treatment, yet its benefits have the capacity to extend to all women undergoing ART, and indications have since broadened to include poor responders, egg donors, those who decline ovarian stimulation, and those who had failed egg maturation in regular IVF. However, clinical outcomes from IVM vary widely likely owing to differing techniques and protocols, including use of hCG triggering and gonadotropin treatment to support follicle growth. Although further research and refinements to the procedure are still ongoing, recent consensus guidelines recognize IVM as no longer an experimental technique and support its therapeutic role if the expertise exists in a particular centre.

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Acknowledgements

The authors acknowledge Dr. Mingju Cao for technical assistance in preparation of the manuscript.

Author information

Authors and Affiliations

  1. Mount Sinai Fertility, Division of Reproductive Sciences, University of Toronto, Toronto, ON, Canada

    Justin Tan

  2. OriginElle Fertility Clinic and Women’s Health Centre, QC, Canada

    Justin Tan & Seang Lin Tan

  3. MUHC Reproductive Centre, Department of Obstetrics and Gynecology, McGill University, QC, Canada

    Seang Lin Tan

Authors
  1. Justin Tan
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  2. Seang Lin Tan
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Correspondence to Seang Lin Tan .

Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Hebrew University - Hadassah Medical Center, Jerusalem, Israel

    Joseph G. Schenker

  2. Gynaecological Endocrinology and Reproduction, University Hospital of Bern, Bern, Switzerland

    Martin H. Birkhaeuser

  3. Department of Reproductive Medicine, University of Pisa, Pisa, Italy

    Andrea R. Genazzani

  4. Campus Kiel, University Clinics of Schleswig-Holstein, Kiel, Germany

    Liselotte Mettler

  5. Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, IL, USA

    John J. Sciarra

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Tan, J., Tan, S.L. (2023). The Essential Role of In Vitro Maturation in Assisted Reproduction. In: Schenker, J.G., Birkhaeuser, M.H., Genazzani, A.R., Mettler, L., Sciarra, J.J. (eds) Hot Topics in Human Reproduction. Reproductive Medicine for Clinicians, vol 3. Springer, Cham. https://doi.org/10.1007/978-3-031-24903-7_16

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  • DOI: https://doi.org/10.1007/978-3-031-24903-7_16

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  • Online ISBN: 978-3-031-24903-7

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