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Primary Central Nervous System Lymphoma: Neuro-Oncologic Approach

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Ocular and Adnexal Lymphoma

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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Abstract

Primary central nervous system lymphoma (PCNSL) is a rare, aggressive, non-Hodgkin diffuse large B-cell lymphoma (DLBCL) in origin. It affects the central nervous system (CNS) compartments including the brain, cranial nerves, spinal cord, and meninges. Brain MRI with and without contrast is considered the method of choice to diagnose PCNSL. Treatment of PCNSL is controversial as it is a relatively rare malignancy with a heterogeneous patient population making comparative prospective trials more challenging. Most data are derived from retrospective, small prospective, and a few trials with variable results that will be summarized in this chapter.

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Change history

  • 25 June 2023

    A correction has been published.

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Author information

Authors and Affiliations

  1. VCU Massey Cancer Center, Richmond, VA, USA

    Ahmad N. Kassem

  2. The Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA

    David M. Peereboom

Authors
  1. Ahmad N. Kassem
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  2. David M. Peereboom
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Corresponding author

Correspondence to David M. Peereboom .

Editor information

Editors and Affiliations

  1. Anant Bajaj Retina Institute, The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, Telangana, India

    Vishal R. Raval

  2. Stanford Medicine, Palo Alto, CA, USA

    Prithvi Mruthyunjaya

  3. Cleveland Clinic, Cole Eye Institute, Cleveland, OH, USA

    Arun D. Singh

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Kassem, A.N., Peereboom, D.M. (2023). Primary Central Nervous System Lymphoma: Neuro-Oncologic Approach. In: Raval, V.R., Mruthyunjaya, P., Singh, A.D. (eds) Ocular and Adnexal Lymphoma. Essentials in Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-031-24595-4_11

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  • DOI: https://doi.org/10.1007/978-3-031-24595-4_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-24594-7

  • Online ISBN: 978-3-031-24595-4

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