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NADPH Oxidases in Arthropods

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NADPH Oxidases Revisited: From Function to Structure

Abstract

Arthropods, especially insects, have been used as physiological models for over a century. Once the microbicidal action of reactive oxygen species produced by mammalian phagocytes was discovered, many arthropods were studied and showed adaptative ROS production in immune defense against pathogenic microorganisms, but also in different physiological situations such as cuticle stabilization, muscle contraction, tissue regeneration and fertility, among other biological roles. Among eukaryotes, arthropods comprise the most diverse group, one that is central to the ecology of all types of environments and has three NADPH oxidase (NOX) isoforms: NOX5, dual oxidase (DUOX) and the arthropod-specific NOX4-art. However, studies are still limited to a few model organisms and biological contexts. In this chapter, we will provide an overview of NOXes found in different groups of arthropods, discuss their roles in physiology, and show how this group contributes to elucidating the evolution of NOX.

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Acknowledgments

We would like to thank Dr. José Henrique Oliveira for critical review of this chapter and Dr. Martha Sorenson for reviewing the English.

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Author notes

  1. Ana Caroline P. Gandara

    Present address: Department of Genetics, University of Wisconsin-Madison, Madison, WI, USA

  2. Ana Caroline P. Gandara

    Present address: Morgridge Institute for Research, Madison, WI, USA

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, School of Public Health, Johns Hopkins University, Baltimore, MD, USA

    Ana Caroline P. Gandara

  2. Department of Genetics, University of Wisconsin-Madison, Madison, WI, USA

    Ana Caroline P. Gandara

  3. Morgridge Institute for Research, Madison, WI, USA

    Ana Caroline P. Gandara

  4. Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    Pedro L. Oliveira

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  1. Ana Caroline P. Gandara
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  1. Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

    Edgar Pick

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Gandara, A.C.P., Oliveira, P.L. (2023). NADPH Oxidases in Arthropods. In: Pick, E. (eds) NADPH Oxidases Revisited: From Function to Structure. Springer, Cham. https://doi.org/10.1007/978-3-031-23752-2_28

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