Abstract
This chapter covers the anatomy and physiology of the nasal passage with special focus on utilizing the nasal passage for delivering drugs for disease treatment. The total length of the nasal cavity is 120–140 mm and the total surface area is about 160 cm2. Also, the total volume is nearly 15 ml. The flow of air and particles in the cavity is controlled by structures within it. The sense of smell is controlled by the nasal cavity’s olfactory area. Nasal blood flow can be affected by a variety of causes. The vasomotor response of the nose is influenced by a variety of stimuli, both locally and generally. Changes in ambient temperature and humidity, topical application of vasoactive medications, external compression of major veins in the neck, trauma, and inflammation are all examples of local factors. This chapter discusses further details about how this nasal passage can be sued for drug delivery and as an absorption surface for the drugs whether small molecules or macro molecules.
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Yadav, H.K.S., Lim-Dy, A., Pathak, Y.V. (2023). An Overview of the Anatomy and Physiology of Nasal Passage from Drug Delivery Point of View. In: Pathak, Y.V., Yadav, H.K.S. (eds) Nasal Drug Delivery. Springer, Cham. https://doi.org/10.1007/978-3-031-23112-4_1
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DOI: https://doi.org/10.1007/978-3-031-23112-4_1
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